Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants

Autor: Scott A. Hollingsworth, Cameron L. Noland, Karin Vroom, Anasuya Saha, Miranda Sam, Qinshan Gao, Haihong Zhou, David U. Grandy, Sujata Singh, Zhiyun Wen, Christopher Warren, Xiaohong Shirley Ma, Daniel Malashock, Jennifer Galli, Gwenny Go, Michael Eddins, Todd Mayhood, Karthik Sathiyamoorthy, Arthur Fridman, Fahimeh Raoufi, Yacob Gomez-Llorente, Andrea Patridge, Yinyan Tang, Shi-Juan Chen, Marc Bailly, Chengjie Ji, Laura J. Kingsley, Alan C. Cheng, Bernhard H. Geierstanger, Daniel M. Gorman, Lan Zhang, Kalyan Pande

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Abstract Coronaviruses have been the causative agent of three epidemics and pandemics in the past two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing coronavirus therapeutic is desirable not only to prevent and treat COVID-19

Externí odkaz: https://doaj.org/article/a9d7ab42a9cb4a6cb05bac47eef92301

Development of a Polymer Ultrasound Contrast Agent Incorporating Nested Carbon Nanodots.

Autor: Shirley MA; Drexel University School of Biomedical Engineering Science and Health Systems, Philadelphia, PA, USA., Arango-Aliaga V; Drexel University School of Biomedical Engineering Science and Health Systems, Philadelphia, PA, USA., Patel A; Drexel University School of Biomedical Engineering Science and Health Systems, Philadelphia, PA, USA., Oeffinger BE; Drexel University School of Biomedical Engineering Science and Health Systems, Philadelphia, PA, USA., Eisenbrey J; Thomas Jefferson University, Philadelphia, PA, USA., Wheatley MA; Drexel University, Philadelphia, PA, USA.

Publikováno v: Ultrasonic imaging [Ultrason Imaging] 2024 Sep 22, pp. 1617346241279112. Date of Electronic Publication: 2024 Sep 22.

Tables S1-S3 from Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types

Autor: Austin Gurney, Timothy Hoey, John Lewicki, Ann M. Kapoun, Min Wang, Gilbert O'Young, Belinda Cancilla, Pete Yeung, Wan-Ching Yen, Michelle Stroud, Andrew Lam, May Ji, Jie Wei, Jalpa Shah, Marcus M. Fischer, Shirley Ma, Cristina Dee-Hoskins, Jennifer Cain, Chris Bond, Fumiko Axelrod, Janak Raval, Cecile Chartier

Supplemental Tables include a list and brief description of xenograft models used in the study, the RSPO1-4 gene expression profile and beta-catenin activation status of all xenograft models, and the microarray analysis for 4 CRC xenograft models aft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c673aa921f31eb42807e17eb99f932
https://doi.org/10.1158/0008-5472.22410080.v1

Data from Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types

Autor: Austin Gurney, Timothy Hoey, John Lewicki, Ann M. Kapoun, Min Wang, Gilbert O'Young, Belinda Cancilla, Pete Yeung, Wan-Ching Yen, Michelle Stroud, Andrew Lam, May Ji, Jie Wei, Jalpa Shah, Marcus M. Fischer, Shirley Ma, Cristina Dee-Hoskins, Jennifer Cain, Chris Bond, Fumiko Axelrod, Janak Raval, Cecile Chartier

Deregulation of the β-catenin signaling has long been associated with cancer. Intracellular components of this pathway, including axin, APC, and β-catenin, are frequently mutated in a range of human tumors, but the contribution of specific extracel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a2dd884372d990c2aeb1d5180b91e4
https://doi.org/10.1158/0008-5472.c.6507911

Breaking the fast, and overcoming the physical and mental barriers for early resumption of postoperative feeding.

Autor: Dongare, Pradeep A.¹ (AUTHOR), Bala, Bhaskar S² (AUTHOR), Goneppanavar, Umesh³ (AUTHOR) dr.umesh@jpmc.com.bn

Publikováno v: Indian Journal of Anaesthesia. Sep2024, Vol. 68 Issue 9, p743-745. 3p.