Zobrazeno 1 - 10 of 75 pro vyhledávání: '"SHINTARO NAKAJIMA"'
1
Akademický článek
TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy
Autor: Takashi Nozawa, Shunsuke Sano, Atsuko Minowa-Nozawa, Hirotaka Toh, Shintaro Nakajima, Kazunori Murase, Chihiro Aikawa, Ichiro Nakagawa
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Xenophage, or autophagy directed against pathogens, might be involved in the clearance of bacterial infection, but the mechanism is unclear. Here, the authors show that ubiquitinated bacteria are bound by TBC1D9 via a Ca2+-dependent interaction to in
Externí odkaz: https://doaj.org/article/181094b3d4dc4048b7968139d1016659
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2
Akademický článek
Group A Streptococcus NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells
Autor: Hirotaka Toh, Ching-Yu Lin, Shintaro Nakajima, Chihiro Aikawa, Takashi Nozawa, Ichiro Nakagawa
Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Group A Streptococcus (GAS) invades epithelial cells causing persistent infection. GAS has a variety of effector proteins that modulate host systems to affect their survival in host environments. The main effector proteins of GAS are NAD-glycohydrola
Externí odkaz: https://doaj.org/article/9d070aaec9154c15b3a034371ac4c48a
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3
Akademický článek
NLRX1 Negatively Regulates Group A Streptococcus Invasion and Autophagy Induction by Interacting With the Beclin 1–UVRAG Complex
Autor: Chihiro Aikawa, Shintaro Nakajima, Miho Karimine, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Shunsuke Yamada, Ichiro Nakagawa
Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Group A Streptococcus (GAS) can invade epithelial cells; however, these bacteria are targeted and eventually destroyed by autophagy. Members of the Nod-like receptor (NLR) family are thought to be critical for the autophagic response to invasive bact
Externí odkaz: https://doaj.org/article/423deb42baf34f31b263c547d12b55ca
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4
Akademický článek
Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG.
Autor: Shintaro Nakajima, Chihiro Aikawa, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Ichiro Nakagawa
Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0170138 (2017)
Anti-apoptotic Bcl-2 and Bcl-xL are proposed to regulate starvation-induced autophagy by directly interacting with Beclin 1. Beclin 1 is also thought to be involved in multiple vesicle trafficking pathways such as endocytosis by binding to Atg14L and
Externí odkaz: https://doaj.org/article/33a875656e604ff7880968409f42d5e2
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5
The Expression of SIRT6 Is Associated With Treatment Outcome in Elder Patients With Oral Cancer
Autor: HARUKA YOSHII, KAZUMASA SEKIHARA, YUKA IDETA, SHINTARO NAKAJIMA, IKUMA KATO, MAKIKO OKUBO-SATO, KEI SUGIURA, KENJI MITSUDO, MITOMU KIOI
Publikováno v: Anticancer Research. 42:3815-3823
SIRT6 is one of seven human sirtuin genes and is known to act as an onco-suppressor gene in colorectal and ovarian cancers, although it is up-regulated in other cancers. Thus, SIRT6 is considered performing both tumor-suppressing and promoting roles.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ab9bb4335b432ce0c17a2b75c2061a
https://doi.org/10.21873/anticanres.15872
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6
Prediction of atherosclerotic changes in cavernous carotid aneurysms based on computational fluid dynamics analysis: a proof-of-concept study
Autor: Shinichiro Sugiyama, Hidenori Oishi, Teiji Tominaga, Shintaro Nakajima, Kuniyasu Niizuma, Yasushi Matsumoto, Kenichi Sato, Miki Fujimura
Publikováno v: Neuroradiology. 64:575-585
Recent computational fluid dynamics (CFD) studies have demonstrated the concurrence of atherosclerotic changes in regions exposed to prolonged blood residence. In this proof-of-concept study, we investigated a small but homogeneous cohort of large, c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8628a46b6e11dfef083ecb6870bac0
https://doi.org/10.1007/s00234-021-02803-x
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8
Modified Extended Double Patch Repair for Interventricular Septum Dissection with Ventricular Septal Rupture
Autor: mio kasai, Shintaro Nakajima, Koji Funaishi, Yohei Numasawa, Kiyoshi Koizumi
Ventricular septal rupture with dissection of the interventricular septum is an extremely rare complication following myocardial infarction, and the optimal surgical strategy remains unclear because of the limited number of surgical cases. Here we re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd6933432d35a8feba163a16fb7c614b
https://doi.org/10.22541/au.165423969.93389885/v1
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