Zobrazeno 1 - 7
of 7
pro vyhledávání: '"SHERIDAN H. LITTLETON"'
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103338- (2024)
Summary: Genome-wide association study loci likely influence disease risk through cis-regulation of nearby genes. We present a protocol for measuring the cis-regulatory activity of risk variants on specific gene promoters in human primary astrocytes
Externí odkaz:
https://doaj.org/article/76945bf39eea46888bd50d7317faf362
Autor:
Matthew C. Pahl, Claudia A. Doege, Kenyaita M. Hodge, Sheridan H. Littleton, Michelle E. Leonard, Sumei Lu, Rick Rausch, James A. Pippin, Maria Caterina De Rosa, Alisha Basak, Jonathan P. Bradfield, Reza K. Hammond, Keith Boehm, Robert I. Berkowitz, Chiara Lasconi, Chun Su, Alessandra Chesi, Matthew E. Johnson, Andrew D. Wells, Benjamin F. Voight, Rudolph L. Leibel, Diana L. Cousminer, Struan F. A. Grant
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Understanding the genetic regulation of hypothalamic function could yield insights into disease pathogenesis, but its inaccessibility has made this challenging. Here the authors present a high-resolution chromatin atlas of a hypothalamic-like neuron
Externí odkaz:
https://doaj.org/article/87b561b18c73423d8f4af95c3968229a
Autor:
Jonathan P. Bradfield, Benjamin F. Voight, Chun Su, Kenyaita M. Hodge, Claudia A. Doege, Rick Rausch, Robert I. Berkowitz, Struan F.A. Grant, Diana L. Cousminer, Sumei Lu, Michelle E. Leonard, Matthew E. Johnson, Alisha Basak, Maria Caterina De Rosa, Matthew C. Pahl, James A. Pippin, Sheridan H. Littleton, Rudolph L. Leibel, Keith Boehm, Andrew D. Wells, Reza K. Hammond, Chiara Lasconi, Alessandra Chesi
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The hypothalamus regulates metabolic homeostasis by influencing behavior and endocrine systems. Given its role governing key traits, such as body weight and reproductive timing, understanding the genetic regulation of hypothalamic development and fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9343345b059b7546f74426e5b0e81c
https://doi.org/10.1530/ey.19.1.2
https://doi.org/10.1530/ey.19.1.2
Publikováno v:
Pediatric Obesity. 17
Childhood obesity rates are on the rise, but there are currently no effective therapies available to slow or halt their progression. Although environmental and lifestyle factors have been implicated in its pathogenesis, childhood obesity is considere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbf580c219f051d4f9ff6fce132dada
https://doi.org/10.1111/ijpo.12968
https://doi.org/10.1111/ijpo.12968
Autor:
SHERIDAN H. LITTLETON, JONATHAN BRADFIELD, JAMES A. PIPPIN, CHUN SU, ALESSANDRA CHESI, ANDREW D. WELLS, ROBERT I. BERKOWITZ, MATTHEW C. PAHL, STRUAN F. GRANT
Publikováno v:
Diabetes. 71
A key limitation of genome-wide association studies (GWAS) is that they do not specify either the underlying causal variant (s) or the effector gene (s) at a given locus. The widely reproduced obesity FAIM2 locus, named arbitrarily after the nearest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc2e5c6c081e7762f49a31ce022e488c
https://doi.org/10.2337/db22-298-or
https://doi.org/10.2337/db22-298-or
Publikováno v:
Mol Diagn Ther
Obesity represents a major health burden to both developed and developing countries. Furthermore, the incidence of obesity is increasing in children. Obesity contributes substantially to mortality in the United States by increasing the risk for type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856994ddfcf4a25886dea3139aaf4251
https://doi.org/10.1007/s40291-020-00496-1
https://doi.org/10.1007/s40291-020-00496-1
Autor:
Sumei Lu, Mariana Argenziano, Kenyaita M. Hodge, Michelle E. Leonard, Sheridan H. Littleton, Gerard D. Schellenberg, Struan F.A. Grant, Elisabetta Manduchi, Matthew E. Johnson, Andrew D. Wells, James A. Pippin, Chun Su, Alessandra Chesi
Publikováno v:
Alzheimer's & Dementia. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4a8eab24615ad6c733612c09258d9b6
https://doi.org/10.1016/j.jalz.2019.06.044
https://doi.org/10.1016/j.jalz.2019.06.044