Race-specific association of an IRGM risk allele with cytokine expression in human subjects

Autor: Teminioluwa Ajayi, Prashant Rai, Min Shi, Kristin A. Gabor, Peer W. F. Karmaus, Julie M. Meacham, Kevin Katen, Jennifer H. Madenspacher, Shepherd H. Schurman, Michael B. Fessler

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract Immunity-related GTPase family M (IRGM), located on human chromosome 5q33.1, encodes a protein that promotes autophagy and suppresses the innate immune response. The minor allele of rs13361189 (−4299T>C), a single nucleotide polymorphism i

Externí odkaz: https://doaj.org/article/e628dea807ef402180a15f40be103787

Questionnaire-based exposome-wide association studies (ExWAS) reveal expected and novel risk factors associated with cardiovascular outcomes in the Personalized Environment and Genes Study

Autor: Lee, Eunice Y., Akhtari, Farida, House, John S., Simpson, Ross J., Jr., Schmitt, Charles P., Fargo, David C., Schurman, Shepherd H., Hall, Janet E., Motsinger-Reif, Alison A.

Publikováno v: In Environmental Research September 2022 212 Part D

Exploring the motivations of research participants who chose not to learn medically actionable secondary genetic findings about themselves

Autor: Schupmann, Will, Miner, Skye A., Sullivan, Haley K., Glover, Jamie R., Hall, Janet E., Schurman, Shepherd H., Berkman, Benjamin E.

Publikováno v: In Genetics in Medicine December 2021 23(12):2281-2288

Association of distance to swine concentrated animal feeding operations with immune-mediated diseases: An exploratory gene-environment study

Autor: Montserrat Ayala-Ramirez, Nathaniel MacNell, Lucy E. McNamee, John A. McGrath, Farida S. Akhtari, Matthew D. Curry, Askia K. Dunnon, Michael B. Fessler, Stavros Garantziotis, Christine G. Parks, David C. Fargo, Charles P. Schmitt, Alison A. Motsinger-Reif, Janet E. Hall, Frederick W. Miller, Shepherd H. Schurman

Publikováno v: Environment International, Vol 171, Iss , Pp 107687- (2023)

Background: Concentrated animal feeding operations (CAFOs) are a source of environmental pollution and have been associated with a variety of health outcomes. Immune-mediated diseases (IMD) are characterized by dysregulation of the normal immune resp

Externí odkaz: https://doaj.org/article/6fd750625d1e400ea420cb3e832fe69d

Evaluating the use of electromyography in UK and European gait laboratories for the assessment of cerebral palsy and other neurological and musculoskeletal conditions.

Autor: Shepherd H; School of Health and Sport Sciences, Liverpool Hope University, Liverpool, L16 9JD, United Kingdom. Electronic address: shepheh@hope.ac.uk., Reeves J; Public Health and Sport Sciences Department, University of Exeter Medical School, Exeter, EX2 4TH, United Kingdom. Electronic address: joannareeves101@hotmail.com., Stewart C; The Robert Jones and Agnes Hunt Orthopaedic Hospital, NHS Foundation Trust, Oswestry, SY10 7AG, United Kingdom; School of Pharmacy and Bioengineering, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Stoke-on-Trent, ST4 7QB. Electronic address: caroline.stewart9@nhs.net.

Publikováno v: Gait & posture [Gait Posture] 2024 Dec 21; Vol. 117, pp. 143-152. Date of Electronic Publication: 2024 Dec 21.