Zobrazeno 1 - 10
of 107
pro vyhledávání: '"SHELDON D. MURPHY"'
The protection of human health and food and fiber resources against the ravages of pests of many sorts is a continuous struggle by all people in the world. The use of chemical pesticides as an aid in this struggle is now also global. These chemicals
Publikováno v:
Toxicological Sciences. 18:221-226
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f975bb1748f30302590dabe95526b8c
https://doi.org/10.1093/toxsci/18.2.221
https://doi.org/10.1093/toxsci/18.2.221
Publikováno v:
Journal of Toxicology and Environmental Health. 33:349-358
Recent studies have provided evidence that formamidine pesticides, such as chlordimeform (CDM; N'-4-chloro-o-tolyl-N,N-dimethylformamidine) or amitraz (AMZ; N'-2-4-(dimethylphenyl)-N-[((2,4-dimethylphenyl)imino)methyl]-N- methanimidamide) exert some
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc0bfdddf22a7a5b8ad4ca396fa9554
https://doi.org/10.1080/15287399109531532
https://doi.org/10.1080/15287399109531532
Publikováno v:
Neurochemical Research. 15:33-39
Activation of cholinergic muscarinic receptors results in an increased turnover of membrane inositol phospholipids. In rat cerebral cortex slices, carbachol- and acetylcholine-induced inositol phosphates ([3H]InsPs) accumulation is maximal in 7 day-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eac7ada1980d2cce67b2f3d14f790a3
https://doi.org/10.1007/bf00969181
https://doi.org/10.1007/bf00969181
Autor:
Gilbert S. Omenn, Rebecca J. Richter, Brian E. McDonald, Arno G. Motulsky, Lucio G. Costa, Clement E. Furlong, Sheldon D. Murphy
Publikováno v:
Toxicology and applied pharmacology. 103(1)
Paraoxon and chlorpyrifos-oxon, the active metabolites of the organophosphorus insecticides parathion and chlorpyrifos, respectively, are hydrolyzed by an "A"-esterase, paraoxonase, which is present in the sera of several mammalian species. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77dc95a41100f6ee55f0c959174be192
https://pubmed.ncbi.nlm.nih.gov/1690462
https://pubmed.ncbi.nlm.nih.gov/1690462
Publikováno v:
International journal of immunopharmacology. 12(1)
A binding site for 3 H-quinuclidinyl benzylate (QNB) has been identified in rat lymphocytes which has the characteristics of a cholinergic muscarinic receptor (Costa, L. G., Kaylor, G. & Murphy, S. D. (1988). Muscarinic cholinergic binding sites on r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a725eacb896abec3aea1a452e95330
https://pubmed.ncbi.nlm.nih.gov/2303319
https://pubmed.ncbi.nlm.nih.gov/2303319
Publikováno v:
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. 79:177-182
1. The metabolism of parathion to para -nitrophenol (PNP) in redfish ( Sciaenops ocellata ) liver microsomes has been both identified and characterized. 2. This mixed-function oxidase (MFO) reaction in redfish requires NADPH and is inhibited by carbo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c5d503f6e6c3b3d175f65d9c0e5074
https://doi.org/10.1016/0742-8413(84)90182-8
https://doi.org/10.1016/0742-8413(84)90182-8
Autor:
Lucio G. Costa, Sheldon D. Murphy
Publikováno v:
Toxicological Sciences. 3:483-488
Previous studies have shown that subchronic treatment of mice with the organophosphate insecticide, disulfoton, or the carbamate insecticide, propoxur, leads to the development of tolerance to their toxicity. Tolerance to disulfoton was due to a decr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01a4af974a8a99bff4ae0acf94bf993
https://doi.org/10.1093/toxsci/3.5.483
https://doi.org/10.1093/toxsci/3.5.483
Autor:
Cheng Wang, Sheldon D. Murphy
Publikováno v:
Toxicology and Applied Pharmacology. 66:409-419
Previous in vitro studies have elucidated species differences in the concentration of organophosphates required for 50% inhibition (IC 50 ) of brain acetylchoinesterase (AChE). In this study, we tested the hypothesis that the differences in IC 50 s b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ecb7b536c8b1535a37f8b69e990e74
https://doi.org/10.1016/0041-008x(82)90307-6
https://doi.org/10.1016/0041-008x(82)90307-6
Publikováno v:
Toxicology. 25:79-97
Administration of multiple, sublethal doses of organophosphorus insecticides induces the development of tolerance to their toxicity. Among the differebt hypotheses investigated to explain the mechanism of this phenomenon, the one which has received t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb0ebebb3994fd220b675c805334b32
https://doi.org/10.1016/0300-483x(82)90021-x
https://doi.org/10.1016/0300-483x(82)90021-x