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Akademický článek

Autophagic degradation of CDK4 is responsible for G0/G1 cell cycle arrest in NVP-BEZ235-treated neuroblastoma

Autor: Zhen Liu, Xiao-Yang Wang, Han-Wei Wang, Shan-Ling Liu, Chao Zhang, Feng Liu, Ying Guo, Feng-Hou Gao

Publikováno v: Cancer Biology & Therapy, Vol 25, Iss 1 (2024)

Background CDK4 is highly expressed and associated with poor prognosis and decreased survival in advanced neuroblastoma (NB). Targeting CDK4 degradation presents a potentially promising therapeutic strategy compared to conventional CDK4 inhibitors. H

Externí odkaz: https://doaj.org/article/02fce2f3dc094d7e8fccb62f6aa4ddfb

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Akademický článek

Enhancement of hyaline cartilage and subchondral bone regeneration in a rat osteochondral defect model through focused extracorporeal shockwave therapy: modulation of transforming growth factor-beta and bone morphogenetic proteins-2, -3, -4, -5, and -7 expression

Autor: Jai-Hong Cheng, Shun-Wun Jhan, Po-Cheng Chen, Shan-Ling Hsu, Ching-Jen Wang, Daniel Moya, Yi-No Wu, Chien-Yiu Huang, Wen-Yi Chou, Kuan-Ting Wu

Publikováno v: Bone & Joint Research, Vol 13, Iss 7, Pp 342-352 (2024)

Aims: To explore the efficacy of extracorporeal shockwave therapy (ESWT) in the treatment of osteochondral defect (OCD), and its effects on the levels of transforming growth factor (TGF)-β, bone morphogenetic protein (BMP)-2, -3, -4, -5, and -7 in t

Externí odkaz: https://doaj.org/article/1c3851d7f3ba4a02bf72ee6888932f31

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Akademický článek

A deep learning framework for identifying and segmenting three vessels in fetal heart ultrasound images

Autor: Laifa Yan, Shan Ling, Rongsong Mao, Haoran Xi, Fei Wang

Publikováno v: BioMedical Engineering OnLine, Vol 23, Iss 1, Pp 1-14 (2024)

Abstract Background Congenital heart disease (CHD) is one of the most common birth defects in the world. It is the leading cause of infant mortality, necessitating an early diagnosis for timely intervention. Prenatal screening using ultrasound is the

Externí odkaz: https://doaj.org/article/336b9153e1954cd0825b32b902b7151d

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