Zobrazeno 1 - 10
of 279
pro vyhledávání: '"SH-SY5Y cell line"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Alzheimer’s disease (AD) is characterized by classic hallmarks such as amyloid plaques and neurofibrillary tangles, however, intensive research has broadened its scope to explore additional underlying mechanisms. Notably, disruptions in metal homeo
Externí odkaz:
https://doaj.org/article/ad55e552c9a24eb28a0ef2d8b067ce10
Autor:
Emilio Rivera López, Cecilia Samaniego López, Carla C. Spagnuolo, Bruno G. Berardino, Agustina Alaimo, Oscar E. Pérez
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 964 (2024)
Targeting drugs to the central nervous system (CNS) is challenging due to the presence of the blood–brain barrier (BBB). The cutting edge in nanotechnology generates optimism to overcome the growing challenges in biomedical sciences through the eff
Externí odkaz:
https://doaj.org/article/e047844fca2446478b69e319986097fc
Publikováno v:
Molecules, Vol 29, Iss 1, p 253 (2024)
Spinetoram is an important semi-synthetic insecticide extensively applied in agriculture. It is neurotoxic to insects, primarily by acting on acetylcholine receptors (nAChRs). However, few studies have examined the neurotoxicity of spinetoram in huma
Externí odkaz:
https://doaj.org/article/e13ebfa8ac7e43d3aeca7e06ac5869d3
Autor:
Angel Carvajal-Oliveros, Maritere Uriostegui-Arcos, Mario Zurita, Erika I. Melchy-Perez, Verónica Narváez-Padilla, Enrique Reynaud
Publikováno v:
IBRO Neuroscience Reports, Vol 13, Iss , Pp 543-551 (2022)
SH-SY5Y is a cell line derived from human neuroblastoma. It is one of the most widely used in vitro models to study Parkinson’s disease. Surprisingly, it has been found that it does not develop a dopaminergic phenotype after differentiation, questi
Externí odkaz:
https://doaj.org/article/40fff418fb254e2fb81f2266afd7ff88
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3325 (2023)
Indole-3-acetonitrile, a compound produced by bacteria and plants as a defense and survival signal in response to attacks, has been recently discovered as a metabolite produced by human cancer cells. This discovery suggests a potential association be
Externí odkaz:
https://doaj.org/article/1c28f9f532a645d6ae36a74027953b39
Akademický článek
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Autor:
Valentina Sturiale, Francesca Bruno, Desiree Brancato, Agata Grazia D’Amico, Grazia Maugeri, Velia D’Agata, Salvatore Saccone, Concetta Federico
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14373 (2023)
A characteristic hallmark of Alzheimer’s disease (AD) is the intracellular accumulation of hyperphosphorylated tau protein, a phenomenon that appears to have associations with oxidative stress, double-stranded DNA breakage, and the de-condensation
Externí odkaz:
https://doaj.org/article/fc795596697a4381b32e0dea2e9e707a
Autor:
Andrea Cediel-Ulloa, Ximiao Yu, Maria Hinojosa, Ylva Johansson, Anna Forsby, Karin Broberg, Joëlle Rüegg
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Methylmercury (MeHg) is a developmental neurotoxicant, and one potential mechanism of MeHg toxicity is epigenetic dysregulation. In a recent meta-analysis of epigenome-wide association studies (EWAS), associations between prenatal MeHg exposure and D
Externí odkaz:
https://doaj.org/article/94dae33ca28f4fb5b1b11c12c2b3eede
Akademický článek
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