Zobrazeno 1 - 10
of 805
pro vyhledávání: '"SH-SY5Y cell"'
Autor:
Mohamed Abdelmonem, Norazalina Saad, Huey Fang Teh, Ahmad Kamil Mohd Jaaffar, Mohamed Ahmed Ibrahim, Maha A. Alhadad, Che Azurahanim Che Abdullah
Publikováno v:
Nano Biomedicine and Engineering, Vol 16, Iss 3, Pp 386-401 (2024)
Neurodegenerative diseases (NDDs) encompass numerous disorders affecting the nervous system’s structure and functions, primarily caused by protein aggregation, oxidative stress, and inflammation. These factors make a significant contribution to the
Externí odkaz:
https://doaj.org/article/95c24c2509134108b0bcdddea4ec57bf
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Alzheimer’s disease (AD) is characterized by classic hallmarks such as amyloid plaques and neurofibrillary tangles, however, intensive research has broadened its scope to explore additional underlying mechanisms. Notably, disruptions in metal homeo
Externí odkaz:
https://doaj.org/article/ad55e552c9a24eb28a0ef2d8b067ce10
Autor:
Emilio Rivera López, Cecilia Samaniego López, Carla C. Spagnuolo, Bruno G. Berardino, Agustina Alaimo, Oscar E. Pérez
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 964 (2024)
Targeting drugs to the central nervous system (CNS) is challenging due to the presence of the blood–brain barrier (BBB). The cutting edge in nanotechnology generates optimism to overcome the growing challenges in biomedical sciences through the eff
Externí odkaz:
https://doaj.org/article/e047844fca2446478b69e319986097fc
Publikováno v:
Biology, Vol 13, Iss 7, p 544 (2024)
Alzheimer’s disease (AD) is a neurodegenerative disorder that is projected by the WHO to affect over 100 million people by 2050. Clinically, AD patients undergoing long-term antipsychotic treatment often experience severe anxiety or depression in l
Externí odkaz:
https://doaj.org/article/0c99818fffd34c0eb99b1274ba64ff1b
Autor:
Orapin Wongsawatkul, Paiwan Buachan, Yamaratee Jaisin, Panaree Busarakumtragul, Sunan Chainakul, Ramida Watanapokasin, Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul
Publikováno v:
Heliyon, Vol 10, Iss 3, Pp e24694- (2024)
Management of neuroblastoma is challenging because of poor response to drugs, chemotherapy resistance, high relapse, and treatment failures. Doxorubicin is a potent anticancer drug commonly used for neuroblastoma treatment. However, doxorubicin induc
Externí odkaz:
https://doaj.org/article/f3770566f24348f49aca9d041c5924e2
Publikováno v:
环境与职业医学, Vol 40, Iss 3, Pp 268-272 (2023)
BackgroundNeurotransmitter secretion disorder induced by chronic manganese poisoning has always been one of the important causes of body injury, but the mechanism of neurotransmitter secretion disorder caused by manganese is not clear at present. Obj
Externí odkaz:
https://doaj.org/article/46ff99123e93416a844d4012db157504
Autor:
Zhina ZHANG, Zhuoran WANG, Mingxuan YANG, Yanli ZHANG, Guowei LIU, Shu FANG, Qiang SU, Qiao NIU, Junhong GUO
Publikováno v:
环境与职业医学, Vol 40, Iss 3, Pp 261-267 (2023)
BackgroundA large amount of iron deposition in the brain can cause neuronal damage by inducing oxidative stress, neuroinflammation, and abnormal mitochondrial function. In addition, iron deposition is also reported to be closely related to the pathog
Externí odkaz:
https://doaj.org/article/ceebed513b2c452eb8be1a3463a2d228
Autor:
YAN Chen, LIU Tao, XUAN Fei
Publikováno v:
Jichu yixue yu linchuang, Vol 43, Iss 1, Pp 152-158 (2023)
Objective To study the protective effect of dexmedetomidine (DEX) on human neuroblastoma cell line SH-SY5Y under anoxia condition and its specific mechanism. Methods SH-SY5Y cells were divided into control group, anoxia group (treated with final conc
Externí odkaz:
https://doaj.org/article/3ec1ee41355b40e4834e6f7eb1a7eaac
Autor:
Angel Carvajal-Oliveros, Maritere Uriostegui-Arcos, Mario Zurita, Erika I. Melchy-Perez, Verónica Narváez-Padilla, Enrique Reynaud
Publikováno v:
IBRO Neuroscience Reports, Vol 13, Iss , Pp 543-551 (2022)
SH-SY5Y is a cell line derived from human neuroblastoma. It is one of the most widely used in vitro models to study Parkinson’s disease. Surprisingly, it has been found that it does not develop a dopaminergic phenotype after differentiation, questi
Externí odkaz:
https://doaj.org/article/40fff418fb254e2fb81f2266afd7ff88
Publikováno v:
Molecules, Vol 29, Iss 1, p 253 (2024)
Spinetoram is an important semi-synthetic insecticide extensively applied in agriculture. It is neurotoxic to insects, primarily by acting on acetylcholine receptors (nAChRs). However, few studies have examined the neurotoxicity of spinetoram in huma
Externí odkaz:
https://doaj.org/article/e13ebfa8ac7e43d3aeca7e06ac5869d3