Onset of erythropoietin response in murine erythroid colony-forming units: assignment to early S-phase in a specific cell generation

Autor: KT Landschulz, SH Boyer, AN Noyes, OC Rogers, LP Frelin

Publikováno v: Blood. 79(10)

Murine erythroid colony-forming units (CFU-E) representing successive cell generations in a six-generation long in vitro maturation sequence were tested for their response to erythropoietin (Epo) by measurement of Epo-exposure times necessary to stim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc45a4a1d4e6ad04cde345b0cfebcf72
https://pubmed.ncbi.nlm.nih.gov/1316785

Changing erythrocyte populations in juvenile chronic myelocytic leukemia: evidence for disordered regulation

Autor: GJ Dover, SH Boyer, WH Zinkham, HH Jr Kazazian, DJ Pinney, A Sigler

Publikováno v: Blood. 49(3)

Fetal and adult erythrocyte characteristics were studied serially in a 30-mo-old female with juvenile chronic myelocytic leukemia. On presentation the erythrocytes exhibited predominantly fetal characteristics as indicated by 69% hemoglobin F (HbF),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16198d452bf560be5f8276883159a202
https://pubmed.ncbi.nlm.nih.gov/264791

Fetal hemoglobin-containing cells have the same mean corpuscular hemoglobin as cells without fetal hemoglobin: a reciprocal relationship between gamma- and beta-globin gene expression in normal subjects and in those with high fetal hemoglobin production

Autor: GJ Dover, SH Boyer

Publikováno v: Blood. 69(4)

We have developed methodology that allows comparison of the mean corpuscular hemoglobin (MCH) of fetal hemoglobin (HbF)-containing red cells (F cells) with the MCH of non-F cells from the same individual. To do this, suspensions of peripheral blood e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32861fec7e42632e34ea2de9972f44d
https://pubmed.ncbi.nlm.nih.gov/2435342

Selection of QPX7831, an Orally Bioavailable Prodrug of Boronic Acid β-Lactamase Inhibitor QPX7728.

Autor: Reddy KR; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States., Parkinson J; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States., Sabet M; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States., Tarazi Z; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States., Boyer SH; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States., Lomovskaya O; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States., Griffith DC; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States., Hecker SJ; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States., Dudley MN; Qpex Biopharma, Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Dec 09; Vol. 64 (23), pp. 17523-17529. Date of Electronic Publication: 2021 Nov 24.

Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.

Autor: Hecker SJ; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States., Reddy KR; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States., Totrov M; ‡Molsoft L.L.C., 11199 Sorrento Valley Road, San Diego, California 92121, United States., Hirst GC; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States., Lomovskaya O; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States., Griffith DC; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States., King P; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States., Tsivkovski R; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States., Sun D; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States., Sabet M; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States., Tarazi Z; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States., Clifton MC; §Beryllium, 3 Preston Court, Bedford, Massachusetts 01730, United States., Atkins K; §Beryllium, 3 Preston Court, Bedford, Massachusetts 01730, United States., Raymond A; §Beryllium, 3 Preston Court, Bedford, Massachusetts 01730, United States., Potts KT; §Beryllium, 3 Preston Court, Bedford, Massachusetts 01730, United States., Abendroth J; §Beryllium, 3 Preston Court, Bedford, Massachusetts 01730, United States., Boyer SH; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States., Loutit JS; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States., Morgan EE; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States., Durso S; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States., Dudley MN; †Rempex Pharmaceuticals, Inc., A Subsidiary of The Medicines Company, 3033 Science Park Rd., Suite 200, San Diego, California 92121, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 May 14; Vol. 58 (9), pp. 3682-92. Date of Electronic Publication: 2015 Mar 17.