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Multiple Antitumor Molecular Mechanisms Are Activated by a Fully Synthetic and Stabilized Pharmaceutical Product Delivering the Active Compound Sulforaphane (SFX-01) in Preclinical Model of Human Glioblastoma

Autor: Alessandro Colapietro, Alessandra Rossetti, Andrea Mancini, Stefano Martellucci, Giuseppe Ocone, Fanny Pulcini, Leda Biordi, Loredana Cristiano, Vincenzo Mattei, Simona Delle Monache, Francesco Marampon, Giovanni Luca Gravina, Claudio Festuccia

Publikováno v: Pharmaceuticals, Vol 14, Iss 11, p 1082 (2021)

Frequent relapses and therapeutic resistance make the management of glioblastoma (GBM, grade IV glioma), extremely difficult. Therefore, it is necessary to develop new pharmacological compounds to be used as a single treatment or in combination with

Externí odkaz: https://doaj.org/article/baf03a3f94c84c318f59603f59efb87f

Multiple Antitumor Molecular Mechanisms Are Activated by a Fully Synthetic and Stabilized Pharmaceutical Product Delivering the Active Compound Sulforaphane (SFX-01) in Preclinical Model of Human Glioblastoma

Autor: Stefano Martellucci, Andrea Mancini, Claudio Festuccia, Giovanni Luca Gravina, Loredana Cristiano, Giuseppe Ocone, Alessandro Colapietro, Francesco Marampon, Simona Delle Monache, Alessandra Rossetti, Fanny Pulcini, Leda Biordi, Vincenzo Mattei

Publikováno v: Pharmaceuticals
Pharmaceuticals; Volume 14; Issue 11; Pages: 1082
Pharmaceuticals, Vol 14, Iss 1082, p 1082 (2021)

Frequent relapses and therapeutic resistance make the management of glioblastoma (GBM, grade IV glioma), extremely difficult. Therefore, it is necessary to develop new pharmacological compounds to be used as a single treatment or in combination with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b0d174589880da04f9571a069c10ea
http://europepmc.org/articles/PMC8626029

Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis

Autor: Ahmed Aljazzar, Boris Chan, Peter D. Lee, Isabel R. Orriss, Yu-Mei Chang, Miriam Piles, Elaine Shervill, Mark Hopkinson, Blandine Poulet, Andrew A. Pitsillides, Behzad Javaheri, Andrea S. Pollard, Roberto Lopes de Souza

Publikováno v: BONE
Bone
Javaheri, B, Poulet, B, Aljazzar, A, de Souza, R, Piles, M, Hopkinson, M, Shervill, E, Pollard, A, Chan, B, Chang, Y-M, Orriss, I R, Lee, P & Pitsillides, A A 2017, ' Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis ', Bone, vol. 103, pp. 308–317 . https://doi.org/10.1016/j.bone.2017.07.028

Osteoarthritis (OA), affecting joints and bone, causes physical gait disability with huge socio-economic burden; treatment remains palliative. Roles for antioxidants in protecting against such chronic disorders have been examined previously. Sulforap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a17e22e7ed4f9ffc144eccbf1c73ce
https://researchonline.rvc.ac.uk/id/eprint/10914/1/10914.pdf

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