Výsledky vyhledávání - "SFN, sulforaphane"

Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis

Autor: Qing, Zhang, Jia, Liu, Huxinyue, Duan, Ruolan, Li, Wei, Peng, Chunjie, Wu

Publikováno v: Journal of Advanced Research

Graphical abstract
Introduction Recently, Nrf2/HO-1 has received extensive attention as the main regulatory pathway of intracellular defense against oxidative stress and is considered an ideal target for alleviating endothelial cell (EC) injury.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9de6be7acea23fd93887832ef07452a1
https://pubmed.ncbi.nlm.nih.gov/35024180

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New possible silver lining for pancreatic cancer therapy: Hydrogen sulfide and its donors

Autor: Jianan Sun, Bo Wu, Dahong Li, Hui-Ming Hua, Bao Ji, Shanshan Luo, Fanxing Xu, Yan Xiao, Peng Wang, Chao Zheng, Keguang Cheng, Xu Hu

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1148-1157 (2021)

As one of the most lethal diseases, pancreatic cancer shows a dismal overall prognosis and high resistance to most treatment modalities. Furthermore, pancreatic cancer escapes early detection during the curable period because early symptoms rarely em

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093ce424e4da05b4ed3727f0392f0661
https://pubmed.ncbi.nlm.nih.gov/34094825

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Relations between approved platinum drugs and non-coding RNAs in mesothelioma

Autor: Bernhard Biersack

Publikováno v: Non-coding RNA Research, Vol 3, Iss 4, Pp 161-173 (2018)
Non-coding RNA Research

Malignant mesothelioma diseases feature an increasing risk due to their severe forms and their association with asbestos exposure. Platinum(II) complexes such as cisplatin and carboplatin are clinically approved for the therapy of mesothelioma often

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cf66f02600358bbd458691c22858d9
http://www.sciencedirect.com/science/article/pii/S2468054018300763

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Interplay of non-coding RNAs and approved antimetabolites such as gemcitabine and pemetrexed in mesothelioma

Autor: Bernhard Biersack

Publikováno v: Non-coding RNA Research
Non-coding RNA Research, Vol 3, Iss 4, Pp 213-225 (2018)

Gemcitabine and pemetrexed are clinically approved antimetabolites for the therapy of mesothelioma diseases. These drugs are often applied in combination with platinum complexes and other drugs. The activity of antimetabolites depended on the express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4aef9ba27f26bc625d6368297e1e44
http://europepmc.org/articles/PMC6257890

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Cinnamic aldehyde inhibits vascular smooth muscle cell proliferation and neointimal hyperplasia in Zucker Diabetic Fatty rats

Autor: Edward Moreira Bahnson, Wulin Jiang, Nicholas Buglak

Publikováno v: Redox Biology, Vol 19, Iss, Pp 166-178 (2018)
Redox Biology

Atherosclerosis remains the number one cause of death and disability worldwide. Atherosclerosis is treated by revascularization procedures to restore blood flow to distal tissue, but these procedures often fail due to restenosis secondary to neointim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d487e24157c57b4e4b649494c580822
http://www.sciencedirect.com/science/article/pii/S2213231718306293

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Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

Autor: Jennifer E. Gallagher, Dorothy Kisielewski, John F. Dillon, Shaun V. Walsh, Diane Cassidy, David J. Harrison, Ritu Sharma, Tadashi Honda, John D. Hayes, Alison D. McNeilly, Michael L.J. Ashford, Albena T. Dinkova-Kostova, Rory J. McCrimmon

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 367-398 (2018)

Background & Aims Nonalcoholic steatohepatitis (NASH) is associated with oxidative stress. We surmised that pharmacologic activation of NF-E2 p45-related factor 2 (Nrf2) using the acetylenic tricyclic bis(cyano enone) TBE-31 would suppress NASH becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdd8de56b5ba950a8c970d72cce7012
https://doi.org/10.1016/j.jcmgh.2017.11.016

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Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein

Autor: Jessica Gasparello, Brunella Grigolo, Elisabetta D'Aversa, Laura Gambari, Chiara Papi, Roberto Gambari, Monica Borgatti, Alessia Finotti

Publikováno v: Phytomedicine

Background A key clinical feature of COVID-19 is a deep inflammatory state known as “cytokine storm” and characterized by high expression of several cytokines, chemokines and growth factors, including IL-6 and IL-8. A direct consequence of this i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2da2ae43f7722602bf89fc50474eb06
https://doi.org/10.1016/j.phymed.2021.153583

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Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity

Autor: Mohammad A. Kaisar, Jee Hyun Park, Ravi K. Sajja, Luca Cucullo, Thomas J. Abbruscato, Taylor Liles, Shikha Prasad, Heidi Villalba

Publikováno v: Redox Biology, Vol 12, Iss, Pp 58-69 (2017)
Redox Biology

Cigarette smoking (CS) is associated with vascular endothelial dysfunction in a causative way primarily related to the TS content of reactive oxygen species (ROS), nicotine, and inflammation. TS promotes glucose intolerance and increases the risk of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9435a62e0fcaf158a4abba1c5f4b96
http://www.sciencedirect.com/science/article/pii/S2213231717300484

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Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases

Autor: Antonio Cuadrado, Marta Pajares, Ana I. Rojo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Redox Biology, Vol 11, Iss, Pp 543-553 (2017)
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Redox Biology

Neurodegenerative diseases are linked to the accumulation of specific protein aggregates, suggesting an intimate connection between injured brain and loss of proteostasis. Proteostasis refers to all the processes by which cells control the abundance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f92176ef6df1b38f56b20a10b5b1ad8

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CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies

Autor: Ángel Juan García-Yagüe, Sebastian Kügler, Isabel Lastres-Becker, Sara Castro-Sánchez

Publikováno v: Redox Biology, Vol 22, Iss, Pp-(2019)
Redox Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname

TAU protein aggregation is the main characteristic of neurodegenerative diseases known as tauopathies. Low-grade chronic inflammation is also another hallmark that indicates crosstalk between damaged neurons and glial cells. Previously, we have demon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0c564146499fa1c2460f04e0e7d5af
http://www.sciencedirect.com/science/article/pii/S221323171831053X

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