Zobrazeno 1 - 10
of 41
pro vyhledávání: '"SEVIM KAHRAMAN"'
Autor:
Sevim Kahraman, Kimitaka Shibue, Dario F De Jesus, Hyunki Kim, Jiang Hu, Debasish Manna, Bridget Wagner, Amit Choudhary, Rohit N Kulkarni
Publikováno v:
eLife, Vol 12 (2023)
Pancreatic α-cells secrete glucagon, an insulin counter-regulatory peptide hormone critical for the maintenance of glucose homeostasis. Investigation of the function of human α-cells remains a challenge due to the lack of cost-effective purificatio
Externí odkaz:
https://doaj.org/article/b75a7103ed324acca5108365e616c62c
Autor:
Giorgio Basile, Sevim Kahraman, Ercument Dirice, Hui Pan, Jonathan M. Dreyfuss, Rohit N. Kulkarni
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Background Human pancreatic islets are a central focus of research in metabolic studies. Transcriptomics is frequently used to interrogate alterations in cultured human islet cells using single-cell RNA-sequencing (scRNA-seq). We introduce s
Externí odkaz:
https://doaj.org/article/0a2587f053b54f06ac12b83d0434a5c0
Autor:
Ercument Dirice, Giorgio Basile, Sevim Kahraman, Danielle Diegisser, Jiang Hu, Rohit N. Kulkarni
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Adaptation to increased insulin demand is mediated by β cell proliferation and neogenesis, among other mechanisms. Although it is known that pancreatic β cells can arise from ductal progenitors, these observations have been limited mostly to the ne
Externí odkaz:
https://doaj.org/article/b5b54765f6be496aa5205bd9295767c8
Autor:
Manoj K. Gupta, Dario F. De Jesus, Sevim Kahraman, Ivan A. Valdez, Farnaz Shamsi, Lian Yi, Adam C. Swensen, Yu-Hua Tseng, Wei-Jun Qian, Rohit N. Kulkarni
Publikováno v:
Molecular Metabolism, Vol 18, Iss , Pp 153-163 (2018)
Objectives: Insulin receptor (IR)-mediated signaling is involved in the regulation of pluripotent stem cells; however, its direct effects on regulating the maintenance of pluripotency and lineage development are not fully understood. The main objecti
Externí odkaz:
https://doaj.org/article/ed089cc8fe424187a8b0aa0f368d3df0
Autor:
Erin R. Okawa, Manoj K. Gupta, Sevim Kahraman, Praneeth Goli, Masaji Sakaguchi, Jiang Hu, Kaiti Duan, Brittany Slipp, Jochen K. Lennerz, Rohit N. Kulkarni
Publikováno v:
Molecular Metabolism, Vol 47, Iss , Pp 101164- (2021)
The insulin and insulin-like growth factor-1 (IGF-1) receptors are important for the growth and development of embryonic tissues. To directly define their roles in the maintenance of pluripotency and differentiation of stem cells, we knocked out both
Externí odkaz:
https://doaj.org/article/9cb65e23eda347039545b70ce93dedde
Akademický článek
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Autor:
Sevim Kahraman, Ercument Dirice, Giorgio Basile, Danielle Diegisser, Jahedul Alam, Bente B. Johansson, Manoj K. Gupta, Jiang Hu, Ling Huang, Chew-Li Soh, Danwei Huangfu, Senthil K. Muthuswamy, Helge Raeder, Anders Molven, Rohit N. Kulkarni
Publikováno v:
Nature Metabolism. 4:76-89
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00a90748897c53ea144f3de6c741aed3
https://doi.org/10.1038/s42255-021-00516-2
https://doi.org/10.1038/s42255-021-00516-2
Autor:
Sevim Kahraman, Kimitaka Shibue, Dario F. De Jesus, Jiang Hu, Debasish Manna, Bridget K. Wagner, Amit Choudhary, Rohit N. Kulkarni
Pancreatic α-cells secrete glucagon, an insulin counter-regulatory peptide hormone critical for the maintenance of glucose homeostasis. Investigation of the function of human α-cells remains a challenge due to the lack of cost-effective purificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6e589fe985591b7b2a0adb956cd6193
https://doi.org/10.1101/2022.11.27.518097
https://doi.org/10.1101/2022.11.27.518097
Autor:
DARIO F. DE JESUS, ZIJIE ZHANG, NATALIE K. BROWN, GIORGIO BASILE, LING XIAO, SEVIM KAHRAMAN, CLAYTON E. MATHEWS, ALVIN C. POWERS, MARK A. ATKINSON, DECIO L. EIZIRIK, ROHIT KULKARNI
Publikováno v:
Diabetes. 71
Innate immunity is directly associated with Type 1 diabetes (T1D) . Recently, N6-methyladenosine (m6A) has been shown to modulate human β-cell biology and innate immunity. Here, we focused on the contribution of m6A in modulating T1D development. RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68e1ab4c4e16b67860b6673728d7b1e6
https://doi.org/10.2337/db22-9-or
https://doi.org/10.2337/db22-9-or
Autor:
Jonnell Candice Small, Rohit N. Kulkarni, Basudeb Maji, Miseon Lee, Stephen J. Lippard, Debasish Manna, Jacob M. Goldberg, Sevim Kahraman, Praveen Kokkonda, Ruth M. Elgamal, Amedeo Vetere, Bridget K. Wagner, Amit Choudhary
Publikováno v:
Journal of the American Chemical Society
The loss of insulin-producing β-cells is the central pathological event in type 1 and 2 diabetes, which has led to efforts to identify molecules to promote β-cell proliferation, protection, and imaging. However, the lack of β-cell specificity of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67c20500e2dfa85118cdda3f5fdcccd
https://doi.org/10.1021/jacs.0c00099
https://doi.org/10.1021/jacs.0c00099