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Akademický článek

Steroid inhibited Serpina3n expression which was positively correlated with the degrees of spinal cord injury

Autor: Haihong Chen, Liang Wu, Yue Zhang, Wang Ding, Yin Xiaofan

Publikováno v: Heliyon, Vol 10, Iss 5, Pp e26649- (2024)

Aims: The aim of our project was to identify proteins associated with the extent of spinal cord injury (SCI) and subsequent long-term neurological recovery. Methods: Through proteomic analysis, we identified proteins that are differentially expressed

Externí odkaz: https://doaj.org/article/e0f80d4759494917b762f0f0e31ee509

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Akademický článek

Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy

Autor: Chong Liu, Xue-Min Zhao, Qiao Wang, Ting-Ting Du, Mo-Xuan Zhang, Hui-Zhi Wang, Ren-Peng Li, Kun Liang, Yuan Gao, Si-Yu Zhou, Tao Xue, Jian-Guo Zhang, Chun-Lei Han, Lin Shi, Liang-Wen Zhang, Fan-Gang Meng

Publikováno v: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-20 (2023)

Abstract Impaired activation and regulation of the extinction of inflammatory cells and molecules in injured neuronal tissues are key factors in the development of epilepsy. SerpinA3N is mainly associated with the acute phase response and inflammator

Externí odkaz: https://doaj.org/article/5b3f3ab4d83a4f35a6d24076f1d649a4

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Akademický článek

Melatonin supplementation protects against traumatic colon injury by regulating SERPINA3N protein expression

Autor: Bo Cao, Jing‐Wang Gao, Qing‐Peng Zhang, Xing‐Ming Xu, Rui‐Yang Zhao, Hang‐Hang Li, Bo Wei

Publikováno v: iMeta, Vol 2, Iss 4, Pp n/a-n/a (2023)

Abstract Traumatic colon injury (TCI) is a typical injury with high mortality. Prolongation of the intervention time window is a potentially useful approach to improving the outcomes of TCI casualties. This study aimed to identify the pathological me

Externí odkaz: https://doaj.org/article/b75809dc83fe438c9e8f92dc73936537

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Akademický článek

The role of Serpina3n in the reversal effect of ATRA on dexamethasone-inhibited osteogenic differentiation in mesenchymal stem cells

Autor: Hai-Tao Jiang, Rui Deng, Yan Deng, Mao Nie, Yi-Xuan Deng, Hong-Hong Luo, Yuan-Yuan Yang, Na Ni, Cheng-Cheng Ran, Zhong-Liang Deng

Publikováno v: Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2021)

Abstract Background Glucocorticoid-induced osteoporosis (GIOP) is the most common secondary osteoporosis. Patients with GIOP are susceptible to fractures and the subsequent delayed bone union or nonunion. Thus, effective drugs and targets need to be

Externí odkaz: https://doaj.org/article/74126868a9fb4ebb829002c460fbdfdf

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Akademický článek

Longitudinal Single-Cell Transcriptomics Reveals a Role for Serpina3n-Mediated Resolution of Inflammation in a Mouse Colitis ModelSummary

Autor: Yen-Ting Ho, Takashi Shimbo, Edward Wijaya, Tomomi Kitayama, Satoshi Takaki, Kentaro Ikegami, Kazuya Miyashita, Yuya Ouchi, Eiichi Takaki, Ryoma Yamamoto, Yasufumi Kaneda, Katsuto Tamai

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 547-566 (2021)

Background & Aims: Proper resolution of inflammation is essential to maintaining homeostasis, which is important as a dysregulated inflammatory response has adverse consequences, even being regarded as a hallmark of cancer. However, our picture of dy

Externí odkaz: https://doaj.org/article/23fc3a8d6ed64cb48e110a16004fa035

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