Zobrazeno 1 - 10
of 876
pro vyhledávání: '"SERCA2a"'
Autor:
Zijing Chen, Haojie Yao, Xiaowei Yao, Ruiyan Zheng, Ying Yang, Zhongqiu Liu, Rongrong Zhang, Yuanyuan Cheng
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117384- (2024)
Heart failure (HF) represents the terminal stage of cardiovascular diseases, with limited therapeutic options currently available. Calotropin (CAL), a cardenolide isolated from Calotropis gigantea, exhibits a similar chemical structure and inhibitory
Externí odkaz:
https://doaj.org/article/56611405304d4e898e0de42180c4b0a6
Publikováno v:
Materials Today Bio, Vol 28, Iss , Pp 101162- (2024)
Fibrotic scarring and impaired myocardial calcium homeostasis serve as the two main factors in the pathology of heart failure following myocardial infarction (MI), leading to poor prognosis and death in patients. Serca2a is a target of interest in ge
Externí odkaz:
https://doaj.org/article/cadc9923d57a45cd87705cdbb9ee8363
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 18, Pp 781-799 (2024)
Xinting Wang,1,* Jiahui Yang,1,* Cheng Lu,2 Yinqin Hu,1 Zhaohui Xu,1 Qiqi Wan,1 Meng Zhang,1 Tianyun Shi,1 Zhirui Liu,1 Yongming Liu1 1Department of Cardiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medici
Externí odkaz:
https://doaj.org/article/4977a148bb5b4319b662c8c4ff8cf43e
Autor:
Sacha V. Kepreotis, Jae Gyun Oh, Mina Park, Jimeen Yoo, Cholong Lee, Mark Mercola, Roger J. Hajjar, Dongtak Jeong
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102174- (2024)
Dystrophic cardiomyopathy is a significant feature of Duchenne muscular dystrophy (DMD). Increased cardiomyocyte cytosolic calcium (Ca2+) and interstitial fibrosis are major pathophysiological hallmarks that ultimately result in cardiac dysfunction.
Externí odkaz:
https://doaj.org/article/1cc3305bec1144ec93e2670c9a1ac745
Autor:
Kasun Kodippili, Chady H. Hakim, Matthew J. Burke, Yongping Yue, James A. Teixeira, Keqing Zhang, Gang Yao, Gopal J. Babu, Roland W. Herzog, Dongsheng Duan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101268- (2024)
Excessive cytosolic calcium accumulation contributes to muscle degeneration in Duchenne muscular dystrophy (DMD). Sarco/endoplasmic reticulum calcium ATPase (SERCA) is a sarcoplasmic reticulum (SR) calcium pump that actively transports calcium from t
Externí odkaz:
https://doaj.org/article/8999a19b16ac45ccb94ac3fd43620ab2
Autor:
Martina Arici, Shih-Che Hsu, Mara Ferrandi, Paolo Barassi, Carlotta Ronchi, Eleonora Torre, Andrea Luraghi, Gwo-Jyh Chang, Patrizia Ferrari, Giuseppe Bianchi, Francesco Peri, Antonio Zaza, Marcella Rocchetti
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background The sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA2a) depression substantially contributes to diastolic dysfunction in heart failure (HF), suggesting that SERCA2a stimulation may be a mechanism-based HF therapy. Istaroxime is a dr
Externí odkaz:
https://doaj.org/article/782d6a7de41e442dbf9d2b9799220397
Publikováno v:
Jorjani Biomedicine Journal, Vol 11, Iss 3, Pp 1-5 (2023)
Background: Aerobic exercise and ginger after myocardial infarction (MI) modify calcium handling. Ginger has cardioprotective effects on cardiovascular disease. This study assessed the effects of aerobic exercise combined with ginger extract (GE) loa
Externí odkaz:
https://doaj.org/article/ec7103ec38454ec7bb4f86469a685e8a
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-11 (2022)
Highlights Design a FRET-based biosensor to monitor PKA dynamics at the RyR2 nanodomains in myocytes Stimulation of β1AR promotes PKA activity at both RyR2 and SERCA2a nanodomains whereas stimulation of β2AR does not Inhibition of PDE3 and PDE4 enh
Externí odkaz:
https://doaj.org/article/7111e54852a64d15b0c529b3d9cf71da
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Akademický článek
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