Zobrazeno 1 - 10
of 164
pro vyhledávání: '"SEONG-SENG TAN"'
Autor:
Mayura V. Wagle, Julia M. Marchingo, Jason Howitt, Seong-Seng Tan, Christopher C. Goodnow, Ian A. Parish
Publikováno v:
Cell Reports, Vol 24, Iss 3, Pp 577-584 (2018)
Summary: Escape from peripheral tolerance checkpoints that control cytotoxic CD8+ T cells is important for cancer immunotherapy and autoimmunity, but pathways enforcing these checkpoints are mostly uncharted. We reveal that the HECT-type ubiquitin li
Externí odkaz:
https://doaj.org/article/f1df04bb8c3940ffbd9e365a5f64deff
Autor:
Jason Howitt, Amanda M Gysbers, Scott Ayton, Francine Carew-Jones, Ulrich Putz, David I Finkelstein, Glenda M Halliday, Seong-Seng Tan
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87119 (2014)
Iron misregulation is a central component in the neuropathology of Parkinson's disease. The iron transport protein DMT1 is known to be increased in Parkinson's brains linking functional transport mechanisms with iron accumulation. The regulation of D
Externí odkaz:
https://doaj.org/article/767b3a60127b4941bb2af571c32d443e
Autor:
Jenny M Gunnersen, Annabel Kuek, Joanna A Phipps, Vicki E Hammond, Theresa Puthussery, Erica L Fletcher, Seong-Seng Tan
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6546 (2009)
BackgroundSeizure-related gene 6 (Sez-6) is expressed in neurons of the mouse brain, retina and spinal cord. In the cortex, Sez-6 plays a role in specifying dendritic branching patterns and excitatory synapse numbers during development.Methodology/pr
Externí odkaz:
https://doaj.org/article/cb31bcf10fd641978c2b8c1980fda647
Autor:
Jason Howitt, Ian A. Parish, Christopher C. Goodnow, Seong-Seng Tan, Julia M. Marchingo, Mayura V Wagle
Publikováno v:
Cell Reports, Vol 24, Iss 3, Pp 577-584 (2018)
Summary: Escape from peripheral tolerance checkpoints that control cytotoxic CD8+ T cells is important for cancer immunotherapy and autoimmunity, but pathways enforcing these checkpoints are mostly uncharted. We reveal that the HECT-type ubiquitin li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4da1302d96aebb468dff9fc7ffc9b53
https://doi.org/10.1016/j.celrep.2018.06.060
https://doi.org/10.1016/j.celrep.2018.06.060
Publikováno v:
Molecular Neurobiology. 56:1628-1636
The regulation of Trk receptors is critical for orchestrating multiple signalling pathways required for developing and maintaining neuronal networks. Activation of Trk receptors results in signalling, internalisation and subsequent degradation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f60f1e6d55dc863e17dd57ff764189
https://doi.org/10.1007/s12035-018-1179-5
https://doi.org/10.1007/s12035-018-1179-5
Publikováno v:
Experimental Neurology. 295:36-45
The two neuronal populations in the cortex, pyramidal neurons and interneurons, can be separated based on neurotransmitter identity, however, within this segregation a large degree of diversity exists. Investigations into the molecular diversity of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c90fb6bc871001cbe131cadff0e08f
https://doi.org/10.1016/j.expneurol.2017.05.006
https://doi.org/10.1016/j.expneurol.2017.05.006
Publikováno v:
Molecular Therapy. 25:1269-1278
Exosomes represent an attractive vehicle for the delivery of biomolecules. However, mechanisms for loading functional molecules into exosomes are relatively unexplored. Here we report the use of the evolutionarily conserved late-domain (L-domain) pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::811e8727869579c64ea3919136237d6f
https://doi.org/10.1016/j.ymthe.2017.03.030
https://doi.org/10.1016/j.ymthe.2017.03.030
Publikováno v:
International Journal of Oral Science
International Journal of Oral Science, Vol 12, Iss 1, Pp 1-9 (2020)
International Journal of Oral Science, Vol 12, Iss 1, Pp 1-9 (2020)
Primary molar ankylosis with infraocclusion can retard dental arch development and cause dental asymmetry. Despite its widespread prevalence, little is known about its molecular etiology and pathogenesis. To address this, RNA sequencing was used to g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074ec9b4e08121b935b5f70b8a0f275e
https://pubmed.ncbi.nlm.nih.gov/32080164
https://pubmed.ncbi.nlm.nih.gov/32080164
Publikováno v:
Methods. :157-163
PTEN was discovered as a membrane-associated tumor suppressor protein nearly two decades ago, but the concept that it can be secreted and taken up by recipient cells is revolutionary. Since then, various laboratories have reported that PTEN is indeed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a62d52db5b9e4f75132caed3b6b7e6
https://doi.org/10.1016/j.ymeth.2014.12.016
https://doi.org/10.1016/j.ymeth.2014.12.016
Autor:
Toru Ouchi, Jason Howitt, Ley-Hian Low, Choo-Peng Goh, Yuh-Lit Chow, Seong-Seng Tan, Yijia Li, Ulrich Putz, John Silke
Publikováno v:
Journal of Biological Chemistry. 290:7141-7150
During injury, cells are vulnerable to apoptosis from a variety of stress conditions including DNA damage causing double-stranded breaks. Without repair, these breaks lead to aberrations in DNA replication and transcription, leading to apoptosis. A m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07533273bae68d0216747fd6213040b5
https://doi.org/10.1074/jbc.m114.613687
https://doi.org/10.1074/jbc.m114.613687