Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone).

Autor: Ivasechko I; Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov14/16, Lviv, 79005, Ukraine., Lozynskyi A; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, Lviv, 79010, Ukraine., Senkiv J; Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov14/16, Lviv, 79005, Ukraine., Roszczenko P; Department of Biotechnology, Faculty of Pharmacy, Medical University of Bialystok, Jana Kilińskiego 1, 15-089, Bialystok, Poland., Kozak Y; Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov14/16, Lviv, 79005, Ukraine., Finiuk N; Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov14/16, Lviv, 79005, Ukraine., Klyuchivska O; Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov14/16, Lviv, 79005, Ukraine., Kashchak N; Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov14/16, Lviv, 79005, Ukraine., Manko N; Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov14/16, Lviv, 79005, Ukraine., Maslyak Z; Institute of Blood Pathology and Transfusion Medicine of National Academy of Medical Sciences of Ukraine, General Chuprynky 45, Lviv, 79044, Ukraine., Lesyk D; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, Lviv, 79010, Ukraine., Karkhut A; Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Polytechnic National University, Bandera 12, Lviv, 79013, Ukraine., Polovkovych S; Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Polytechnic National University, Bandera 12, Lviv, 79013, Ukraine., Czarnomysy R; Department of Synthesis and Technology of Drugs, Faculty of Pharmacy, Medical University of Bialystok, Jana Kilińskiego 1, 15-089, Bialystok, Poland., Szewczyk O; Department of Synthesis and Technology of Drugs, Faculty of Pharmacy, Medical University of Bialystok, Jana Kilińskiego 1, 15-089, Bialystok, Poland., Kozytskiy A; Enamine Ltd, Chervonotkatska Street 78, Kyiv, 02094, Ukraine; L.V. Pysarzhevsky Institute of Physical Chemistry, National Academy of Sciences of Ukraine, Nauky Avenue 31, Kyiv, 03028, Ukraine., Karpenko O; Enamine Ltd, Chervonotkatska Street 78, Kyiv, 02094, Ukraine., Khyluk D; Department of Organic Chemistry, Faculty of Pharmacy with Medical Analytics Division, Medical University of Lublin, 4A Chodzki, Lublin, 20-093, Poland., Gzella A; Department of Organic Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland., Bielawski K; Department of Synthesis and Technology of Drugs, Faculty of Pharmacy, Medical University of Bialystok, Jana Kilińskiego 1, 15-089, Bialystok, Poland., Bielawska A; Department of Biotechnology, Faculty of Pharmacy, Medical University of Bialystok, Jana Kilińskiego 1, 15-089, Bialystok, Poland., Dzubak P; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and University Hospital in Olomouc, Hnevotinska 5, 77900, Olomouc, Czech Republic., Gurska S; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and University Hospital in Olomouc, Hnevotinska 5, 77900, Olomouc, Czech Republic., Hajduch M; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and University Hospital in Olomouc, Hnevotinska 5, 77900, Olomouc, Czech Republic., Stoika R; Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov14/16, Lviv, 79005, Ukraine. Electronic address: stoika.rostyslav@gmail.com., Lesyk R; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, Lviv, 79010, Ukraine; Department of Biotechnology and Cell Biology, Medical College, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225, Rzeszow, Poland. Electronic address: dr_r_lesyk@org.lviv.net.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Apr 05; Vol. 252, pp. 115304. Date of Electronic Publication: 2023 Mar 24.

1,4-Naphthoquinone Motif in the Synthesis of New Thiopyrano[2,3- d ]thiazoles as Potential Biologically Active Compounds.

Autor: Lozynskyi A; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine., Senkiv J; Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov14/16, 79005 Lviv, Ukraine., Ivasechko I; Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov14/16, 79005 Lviv, Ukraine., Finiuk N; Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov14/16, 79005 Lviv, Ukraine., Klyuchivska O; Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov14/16, 79005 Lviv, Ukraine., Kashchak N; Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov14/16, 79005 Lviv, Ukraine., Lesyk D; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine., Karkhut A; Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Polytechnic National University, Bandera 12, 79013 Lviv, Ukraine., Polovkovych S; Department of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Polytechnic National University, Bandera 12, 79013 Lviv, Ukraine., Levytska O; Department of Organization and Economics of Pharmacy, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine., Karpenko O; Enamine Ltd., 23 Alexandra Matrosova, 01103 Kyiv, Ukraine., Boshkayeva A; Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany, Asfendiyarov Kazakh National Medical University, Almaty 050000, Kazakhstan., Sayakova G; Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany, Asfendiyarov Kazakh National Medical University, Almaty 050000, Kazakhstan., Gzella A; Department of Organic Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland., Stoika R; Institute of Cell Biology of National Academy of Sciences of Ukraine, Drahomanov14/16, 79005 Lviv, Ukraine., Lesyk R; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine.; Department of Biotechnology and Cell Biology, Medical College, University of Information Technology and Management in Rzeszow, Sucharskiego 2, 35-225 Rzeszow, Poland.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2022 Nov 04; Vol. 27 (21). Date of Electronic Publication: 2022 Nov 04.

Synthesis and Anticancer Activity Evaluation of 5-[2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-thiazolidinones.

Autor: Buzun K; Department of Biotechnology, Medical University of Bialystok, Jana Kilińskiego 1, 15-089 Bialystok, Poland., Kryshchyshyn-Dylevych A; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine., Senkiv J; Institute of Cell Biology of National Academy of Sciences of Ukraine, 14/16 Drahomanov Str., 79005 Lviv, Ukraine., Roman O; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine., Gzella A; Department of Organic Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland., Bielawski K; Department of Synthesis and Technology of Drugs, Medical University of Bialystok, 15-089 Bialystok, Poland., Bielawska A; Department of Biotechnology, Medical University of Bialystok, Jana Kilińskiego 1, 15-089 Bialystok, Poland., Lesyk R; Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010 Lviv, Ukraine.; Department of Public Health, Dietetics and Lifestyle Disorders, Faculty of Medicine, University of Information Technology and Management in Rzeszow, 35-225 Rzeszow, Poland.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2021 May 20; Vol. 26 (10). Date of Electronic Publication: 2021 May 20.

Characterization of naphthoquinones as inhibitors of glutathione reductase and inducers of intracellular oxidative stress.

Autor: Chen, Xiaowan¹ (AUTHOR), Ma, Yan² (AUTHOR), Yang, Ziming¹ (AUTHOR), Shen, Dingjie¹ (AUTHOR), Li, Xia^1,3,4 (AUTHOR), Ni, Maowei³ (AUTHOR), Xu, Xiaoling⁵ (AUTHOR) xuxiaoling@tongji.edu.cn, Chen, Wei^1,3,4,6 (AUTHOR) chenwei@zjcc.org.cn

Publikováno v: Redox Report. Dec2024, Vol. 29 Issue 1, p1-11. 11p.

Trastuzumab Potentiates Antitumor Activity of Thiopyrano[2,3- d ]Thiazole Derivative in AGS Gastric Cancer Cells.

Autor: Roszczenko, Piotr¹ (AUTHOR) piotr.roszczenko@sd.umb.edu.pl, Szewczyk-Roszczenko, Olga Klaudia² (AUTHOR), Gornowicz, Agnieszka¹ (AUTHOR) piotr.roszczenko@sd.umb.edu.pl, Czarnomysy, Robert² (AUTHOR), Lozynskyi, Andrii³ (AUTHOR), Bielawski, Krzysztof² (AUTHOR), Lesyk, Roman³ (AUTHOR), Bielawska, Anna¹ (AUTHOR)

Publikováno v: Molecules. Nov2024, Vol. 29 Issue 21, p5117. 18p.