Zobrazeno 1 - 10
of 541
pro vyhledávání: '"SEN HAN"'
Autor:
Yajie Sun, Jeffrey Patterson-Fortin, Sen Han, Zhe Li, Zuzanna Nowicka, Yuna Hirohashi, Susan Kilgas, Jae Kyo Yi, Alexander Spektor, Wojciech Fendler, Panagiotis A. Konstantinopoulos, Dipanjan Chowdhury
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract 53BP1 nucleates the anti-end resection machinery at DNA double-strand breaks, thereby countering BRCA1 activity. Loss of 53BP1 leads to DNA end processing and homologous recombination in BRCA1-deficient cells. Consequently, BRCA1-mutant tumo
Externí odkaz:
https://doaj.org/article/d04a618cd1684767a7029059b0c86b6d
Publikováno v:
Case Studies in Construction Materials, Vol 21, Iss , Pp e03617- (2024)
The grooved-filled asphalt pavement has certain advantages in terms of pavement ice-breaking and anti-skid. However, the performances of the filling material limit its development. In this study, a polyurethane urea (PUU) - waste rubber particles (WR
Externí odkaz:
https://doaj.org/article/644cd64c87c5442b9ec9be2b2f83b268
Publikováno v:
Meitan xuebao, Vol 49, Iss 1, Pp 320-336 (2024)
With the increasing depth of coal mining, the stability control of surrounding rock in deep roadway has become one of major problems in the mining field, and the effect of surrounding rock control in deep roadway is directly related to the safe produ
Externí odkaz:
https://doaj.org/article/8cd8c41f48a543529a9c5e0ce80cafc7
Autor:
Panpan Zhang, Minting Ma, Jun Nie, Ling Dai, Weiheng Hu, Jie Zhang, Di Wu, Xiaoling Chen, Xiangjuan Ma, Guangming Tian, Sen Han, Jieran Long, Yang Wang, Ziran Zhang, Qianyun Hao, Jian Fang
Publikováno v:
Heliyon, Vol 10, Iss 4, Pp e26026- (2024)
Purpose: The purpose of this study is to investigate the efficacy and safety of immune checkpoint inhibitors (ICIs) or plus with chemotherapy in older patients. Methods: We enrolled 110 older patients with non-small cell lung cancer (NSCLC ≥75 year
Externí odkaz:
https://doaj.org/article/3f6dc24e9ea14686aec8d5b8224420b6
Autor:
Yang Wang, Jun Nie, Ling Dai, Weiheng Hu, Sen Han, Jie Zhang, Xiaoling Chen, Xiangjuan Ma, Guangming Tian, Di Wu, Ziran Zhang, Jieran Long, Jian Fang
Publikováno v:
BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-17 (2023)
Abstract Background Lung Adenocarcinoma (LUAD) is a major component of lung cancer. Endoplasmic reticulum stress (ERS) has emerged as a new target for some tumor treatments. Methods The expression and clinical data of LUAD samples were downloaded fro
Externí odkaz:
https://doaj.org/article/59ff762cbd314f2891c656e359565252
Autor:
Huan Wang, Yiming Wang, Jiongyuan Li, Ziyi He, Sarah A. Boswell, Mirra Chung, Fuping You, Sen Han
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-21 (2023)
Abstract Background Tyrosine kinase inhibitors (TKIs) are anti-cancer therapeutics often prescribed for long-term treatment. Many of these treatments cause cardiotoxicity with limited cure. We aim to clarify molecular mechanisms of TKI-induced cardio
Externí odkaz:
https://doaj.org/article/96fac43db70b418382c36d847c4bcc4f
Publikováno v:
Cells, Vol 13, Iss 11, p 950 (2024)
Fusarium pseudograminearum causes destructive crown disease in wheat. The velvet protein family is a crucial regulator in development, virulence, and secondary metabolism of fungi. We conducted a functional analysis of FpVelB using a gene replacement
Externí odkaz:
https://doaj.org/article/e58d09317cc44a009a8ab30ddd7e2e28
Autor:
Aina He, Songhai Tian, Oded Kopper, Daniel J Horan, Peng Chen, Roderick T Bronson, Ren Sheng, Hao Wu, Lufei Sui, Kun Zhou, Liang Tao, Quan Wu, Yujing Huang, Zan Shen, Sen Han, Xueqing Chen, Hong Chen, Xi He, Alexander G Robling, Rongsheng Jin, Hans Clevers, Dongxi Xiang, Zhe Li, Min Dong
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002353 (2023)
Wnt signaling pathways are transmitted via 10 homologous frizzled receptors (FZD1-10) in humans. Reagents broadly inhibiting Wnt signaling pathways reduce growth and metastasis of many tumors, but their therapeutic development has been hampered by th
Externí odkaz:
https://doaj.org/article/c1f3079f1d4342a0a3d6ba9ffe231f87
Autor:
Yang Wang, Xuanye Zhang, Dan Tian, Sen Han, Jie Zhang, Jun Nie, Ling Dai, Weiheng Hu, Xiaoling Chen, Xiangjuan Ma, Guangming Tian, Di Wu, Ziran Zhang, Jieran Long, Jian Fang
Publikováno v:
Cancer Medicine, Vol 12, Iss 3, Pp 2303-2311 (2023)
Abstract Background Currently there is no standard therapy recommended for second‐line treatment for thymic carcinoma. Our study compared multidrug chemotherapy, single‐agent chemotherapy, and PD‐1 inhibitors in patients diagnosed with advanced
Externí odkaz:
https://doaj.org/article/c14739a621ec4157b7d0b15363ae0eff
Publikováno v:
Applied Sciences, Vol 14, Iss 5, p 1682 (2024)
The deformation and re-crushing characteristics of different lithological caving crushed gangues in mine goaf directly affect the overburden strata movement, which significantly affects the surface subsidence of mining goaf. The effect of particle si
Externí odkaz:
https://doaj.org/article/25b576b7fb1a486399b6e7b8b2314c6c