The algal selenoproteomes

Autor: Yan Zhang, Lianchang Chen, Lin Zheng, Maona Zhang, Qiong Liu, Jiazuan Ni, Gaopeng Li, Yiqian Lu, Liang Jiang

Publikováno v: BMC Genomics, Vol 21, Iss 1, Pp 1-16 (2020)
BMC Genomics

Background Selenium is an essential trace element, and selenocysteine (Sec, U) is its predominant form in vivo. Proteins that contain Sec are selenoproteins, whose special structural features include not only the TGA codon encoding Sec but also the S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507685683a88edd825b5ef4962316ecf
http://link.springer.com/article/10.1186/s12864-020-07101-z

Challenges of site-specific selenocysteine incorporation into proteins byEscherichia coli

Autor: Dieter Söll, Xian Fu, Anastasia Sevostyanova

Publikováno v: RNA Biology. 15:461-470

Selenocysteine (Sec), a rare genetically encoded amino acid with unusual chemical properties, is of great interest for protein engineering. Sec is synthesized on its cognate tRNA (tRNA(Sec)) by the concerted action of several enzymes. While all other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ca6296a045ac517498b7b0f32dff3b
https://doi.org/10.1080/15476286.2018.1440876

Generation of Recombinant Mammalian Selenoproteins through Genetic Code Expansion with Photocaged Selenocysteine

Autor: Laura C. Edinger, Jennifer C. Peeler, Rachel E. Kelemen, Abhishek Chatterjee, Jingjia Chen, Masahiro Abo, Eranthie Weerapana

Selenoproteins contain the amino acid selenocysteine and are found in all domains of life. The functions of many selenoproteins are poorly understood, partly due to difficulties in producing recombinant selenoproteins for cell-biological evaluation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86816450e4bbce4c207d76ab74f66cab

LokiarchaeotaMarks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems

Autor: Bruno Manta, Marco Mariotti, Toni Gabaldón, Roderic Guigó, Andreu Bofill, Vadim N. Gladyshev, Alexei V. Lobanov, Didac Santesmasses

Publikováno v: Molecular Biology and Evolution
Recercat. Dipósit de la Recerca de Catalunya
instname

Selenocysteine (Sec) is the 21st amino acid in the genetic code, inserted in response to UGA codons with the help of RNA structures, the SEC Insertion Sequence (SECIS) elements. The three domains of life feature distinct strategies for Sec insertion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a45e1dcf63e94f82558d2bfc3c904c
https://doi.org/10.1093/molbev/msw122

Selenium-regulated hierarchy of human selenoproteome in cancerous and immortalized cells lines

Autor: Zahia Touat-Hamici, Juliusz Bianga, Anne-Laure Bulteau, Hélène Jean-Jacques, Joanna Szpunar, Ryszard Lobinski, Laurent Chavatte

Publikováno v: Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2018, 1862, pp.2493-2505. ⟨10.1016/j.bbagen.2018.04.012⟩
BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2018, pp.S0304-4165(18)30105-3. ⟨10.1016/j.bbagen.2018.04.012⟩
BBA-Biochimica et Biophysica Acta, Elsevier, 2018, pp.S0304-4165(18)30105-3. 〈10.1016/j.bbagen.2018.04.012〉
Biochimica et Biophysica Acta (BBA)-General Subjects, 2018, 1862, pp.2493-2505. ⟨10.1016/j.bbagen.2018.04.012⟩

International audience; Background: Selenoproteins (25 genes in human) co-translationally incorporate selenocysteine using a UGA codon, normally used as a stop signal. The human selenoproteome is primarily regulated by selenium bioavailability with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bd9e306f7c7892774ed23ae8ff01b9
https://hal.archives-ouvertes.fr/hal-03133602