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Akademický článek

CHARACTERIZATION OF A 3D IN VITRO TUMOR AND STROMAL SPHEROID MODEL FOR EVALUATING THE SPATIAL DISTRIBUTION OF STROMAL AND TUMOR CELLS AND THE INFILTRATION OF IMMUNE CELLS IN THE TUMOR MICROENVIRONMENT OF PANCREATIC DUCTAL ADENOCARCINOMA

Autor: SEC Silva, CCOM Bonaldo, PVB Palma, SR Caruso, MD Orellana, PLP Xavier, RA Panepucci

Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S1226- (2024)

PDA, the most frequent and aggressive subtype of pancreatic cancer, has a stroma-rich TME (̃80% of tumor mass). The characteristically hypoxic TME orchestrates an extensive metabolic reprogramming in immune, stromal and tumor cells, inducing epithel

Externí odkaz: https://doaj.org/article/1dfcbf6f1a8c4ded8f94979379e442c6

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Akademický článek

Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors

Publikováno v: JCI Insight, Vol 6, Iss 20 (2021)

The PD-1/PD-L1 pathway is a key immune checkpoint that regulates T cell activation. There is strong rationale to develop PD-1 agonists as therapeutics against autoimmunity, but progress in this area has been limited. Here, we generated T cell recepto

Externí odkaz: https://doaj.org/article/76d2b586086f49e3988424380f1b73ad

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Akademický článek

An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment

Autor: Leena Halim, Marco Romano, Reuben McGregor, Isabel Correa, Polychronis Pavlidis, Nathali Grageda, Sec-Julie Hoong, Muhammed Yuksel, Wayel Jassem, Rosalind F. Hannen, Mark Ong, Olivia Mckinney, Bu’Hussain Hayee, Sophia N. Karagiannis, Nicholas Powell, Robert I. Lechler, Estefania Nova-Lamperti, Giovanna Lombardi

Publikováno v: Cell Reports, Vol 20, Iss 3, Pp 757-770 (2017)

Regulatory T cells (Tregs) play a pivotal role in maintaining immunological tolerance, but they can also play a detrimental role by preventing antitumor responses. Here, we characterized T helper (Th)-like Treg subsets to further delineate their biol

Externí odkaz: https://doaj.org/article/ac5022db56944e29b0db055e9ca4656e

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Kniha

Electing the President : An Interactive Simulation on the Electoral Process (Rev. Ed. , Grades 4-8). [elektronicky zdroj]

Autor: Sec, Betty M.

Externí odkaz: Kolekce e-knih KNAV (Registrovani uzivatele: plny text online 5 minut, dalsi pristup na vyzadani. Registered users: full text online 5 minutes, further access on requests.)

Akademický článek

Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells

Autor: Cristiano Scottà, Giorgia Fanelli, Sec Julie Hoong, Marco Romano, Estefania Nova Lamperti, Mitalee Sukthankar, Giuliana Guggino, Henrieta Fazekasova, Kulachelvy Ratnasothy, Pablo D. Becker, Behdad Afzali, Robert I. Lechler, Giovanna Lombardi

Publikováno v: Haematologica, Vol 101, Iss 1 (2016)

Immunosuppressive drugs in clinical transplantation are necessary to inhibit the immune response to donor antigens. Although they are effective in controlling acute rejection, they do not prevent long-term transplant loss from chronic rejection. In a

Externí odkaz: https://doaj.org/article/e6b90880f686439bb880eefbc18e9690

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Report

Controllable shifting, steering, and expanding of light beam based on multi-layer liquid-crystal cells

Autor: Mur, Urban, Ravnik, Miha, Seč, David

Publikováno v: Scientific Reports 12.1 (2022): 1-13

Shaping and steering of light beams is essential in many modern applications, ranging from optical tweezers, camera lenses, vision correction to 3D displays. However, current realisations require increasingly greater tunability and aim for lesser spe

Externí odkaz: http://arxiv.org/abs/2211.06169

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