Zobrazeno 1 - 10
of 15 981
pro vyhledávání: '"SEC"'
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 46, Iss , Pp S1226- (2024)
PDA, the most frequent and aggressive subtype of pancreatic cancer, has a stroma-rich TME (̃80% of tumor mass). The characteristically hypoxic TME orchestrates an extensive metabolic reprogramming in immune, stromal and tumor cells, inducing epithel
Externí odkaz:
https://doaj.org/article/1dfcbf6f1a8c4ded8f94979379e442c6
Autor:
Adam P. Curnock, Giovanna Bossi, Jyothi Kumaran, Lindsay J. Bawden, Rita Figueiredo, Rajeevkumar Tawar, Katherine Wiseman, Emma Henderson, Sec Julie Hoong, Veronica Gonzalez, Hemza Ghadbane, David E.O. Knight, Ronan O’Dwyer, David X. Overton, Christina M. Lucato, Nicola M.G. Smith, Carlos R. Reis, Keith Page, Lorraine M. Whaley, Michelle L. McCully, Stephen Hearty, Tara M. Mahon, Peter Weber
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
The PD-1/PD-L1 pathway is a key immune checkpoint that regulates T cell activation. There is strong rationale to develop PD-1 agonists as therapeutics against autoimmunity, but progress in this area has been limited. Here, we generated T cell recepto
Externí odkaz:
https://doaj.org/article/76d2b586086f49e3988424380f1b73ad
Autor:
Leena Halim, Marco Romano, Reuben McGregor, Isabel Correa, Polychronis Pavlidis, Nathali Grageda, Sec-Julie Hoong, Muhammed Yuksel, Wayel Jassem, Rosalind F. Hannen, Mark Ong, Olivia Mckinney, Bu’Hussain Hayee, Sophia N. Karagiannis, Nicholas Powell, Robert I. Lechler, Estefania Nova-Lamperti, Giovanna Lombardi
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 757-770 (2017)
Regulatory T cells (Tregs) play a pivotal role in maintaining immunological tolerance, but they can also play a detrimental role by preventing antitumor responses. Here, we characterized T helper (Th)-like Treg subsets to further delineate their biol
Externí odkaz:
https://doaj.org/article/ac5022db56944e29b0db055e9ca4656e
Autor:
Cristiano Scottà, Giorgia Fanelli, Sec Julie Hoong, Marco Romano, Estefania Nova Lamperti, Mitalee Sukthankar, Giuliana Guggino, Henrieta Fazekasova, Kulachelvy Ratnasothy, Pablo D. Becker, Behdad Afzali, Robert I. Lechler, Giovanna Lombardi
Publikováno v:
Haematologica, Vol 101, Iss 1 (2016)
Immunosuppressive drugs in clinical transplantation are necessary to inhibit the immune response to donor antigens. Although they are effective in controlling acute rejection, they do not prevent long-term transplant loss from chronic rejection. In a
Externí odkaz:
https://doaj.org/article/e6b90880f686439bb880eefbc18e9690
Publikováno v:
Scientific Reports 12.1 (2022): 1-13
Shaping and steering of light beams is essential in many modern applications, ranging from optical tweezers, camera lenses, vision correction to 3D displays. However, current realisations require increasingly greater tunability and aim for lesser spe
Externí odkaz:
http://arxiv.org/abs/2211.06169
Autor:
Lim, Annette M *, Le Tourneau, Christophe, Hurt, Chris, Laskar, Sarbani G, Steuer, Conor E, Chow, Velda L Y, Szturz, Petr, Henson, Christina, Day, Andrew T, Bates, James E, Lazarakis, Smaro, McDowell, Lachlan, Mehanna, Hisham, Yom, Sue S **
Publikováno v:
In The Lancet Oncology July 2024 25(7):e308-e317
Autor:
Lim, Annette M *, McDowell, Lachlan, Hurt, Chris, Le Tourneau, Christophe, Homma, Akihiro, Shenouda, George, Thomson, David J, Moya-Plana, Antoine, Henson, Christina, Szturz, Petr, Day, Andrew T, Bates, James E, Lazarakis, Smaro, Thariat, Juliette, Psyrri, Amanda, Mehanna, Hisham, Yom, Sue S **
Publikováno v:
In The Lancet Oncology July 2024 25(7):e318-e330
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