Characterization of a new apolipoprotein E5 variant detected in two French-Canadian subjects

Autor: F Mailly, CF Xu, M Xhignesse, S Lussier-Cacan, PJ Talmud, J Davignon, SE Humphries, AC Nestruck

Publikováno v: Journal of Lipid Research, Vol 32, Iss 4, Pp 613-620 (1991)

We have found a novel apoE5 mutation, using isoelectric focusing (IEF), in two apparently unrelated French-Canadian subjects. Co-dominant inheritance was demonstrated in the family of the first proband, a healthy male subject. The presence of the apo

Externí odkaz: https://doaj.org/article/042d3f7065ae4f3d9119be50951d5e3a

POSA136 What Are the Benefits of Treatment of Familial Hypercholesterolaemia? A Cost-Effectiveness Model Based on Real-World Data Considering Cholesterol Burden

Autor: R Faria, P Saramago, E Cox, S Weng, B Iyen, R Akyea, SE Humphries, N Qureshi, B Woods

Publikováno v: Value in Health. 25:S60

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27b3102d8890f90558a7e18bd29e48af
https://doi.org/10.1016/j.jval.2021.11.279

Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study

Autor: Ks, Vimaleswaran, Cavadino A, Dj, Berry, LifeLines Cohort Study investigators, Jorde R, Ak, Dieffenbach, Lu C, Ac, Alves, Hj, Heerspink, Tikkanen E, Eriksson J, Wong A, Mangino M, Ka, Jablonski, Im, Nolte, Dk, Houston, Ts, Ahluwalia, Pj, Most, Pasko D, Zgaga L, Thiering E, Vitart V, Rm, Fraser, Je, Huffman, Ra, Boer, Schöttker B, Ku, Saum, Mi, Mccarthy, Dupuis J, Kh, Herzig, Sebert S, Pouta A, Laitinen J, Me, Kleber, Navis G, Lorentzon M, Jameson K, Arden N, Ja, Cooper, Acharya J, Hardy R, Raitakari O, Ripatti S, Lk, Billings, Lahti J, Osmond C, Bw, Penninx, Rejnmark L, Kk, Lohman, Paternoster L, Rp, Stolk, Dg, Hernandez, Byberg L, Hagström E, Melhus H, Ingelsson E, Mellström D, Ljunggren O, Tzoulaki I, McLachlan S, Theodoratou E, Cm, Tiesler, Jula A, Navarro P, Af, Wright, Polasek O, International Consortium for Blood Pressure (ICBP), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, Global Blood Pressure Genetics (Global BPGen) consortium, Caroline Hayward, Jf, Wilson, Rudan I, Salomaa V, Heinrich J, Campbell H, Jf, Price, Karlsson M, Lind L, Michaëlsson K, Bandinelli S, Tm, Frayling, Ca, Hartman, Ti, Sørensen, Sb, Kritchevsky, Bl, Langdahl, Jg, Eriksson, Jc, Florez, Td, Spector, Lehtimäki T, Kuh D, Se, Humphries, Cooper C, Ohlsson C, März W, Mh, Borst, Kumari M, Mika Kivimaki, Tj, Wang, Power C, Brenner H, Grimnes G, van der Harst P, Snieder H, Ad, Hingorani, Pilz S, Jc, Whittaker, Järvelin MR, Hyppönen E

Publikováno v: Europe PubMed Central

BACKGROUND: Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::425db1caf29762d177e8497e030e1999
https://researchonline.lshtm.ac.uk/id/eprint/1878076/1/NIHMS721970-supplement-Supplementary_Appendix.pdf

Identification of a novel (-748G>A) polymorphism in the promoter of the gene for CRP: lack of association with CRP levels in healthy men

Autor: F Zito, SE Humphries, George J. Miller, E Hawe, A Hingorani

Publikováno v: BMC News and views. 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bae08a9e0bda4a18eca3f2227ed58ca
https://doi.org/10.1186/2048-4623-1-s2-050

Gene-environment interaction in the determination of levels of haemostatic variables involved in thrombosis and fibrinolysis

Autor: Se, Humphries, Ja, Henry, Hugh Montgomery

Publikováno v: Europe PubMed Central

Although a specific genotype may be associated in healthy subjects with modest differences in levels of a risk factor for thrombosis, this effect may be larger or smaller in subgroups of subjects. Documenting such gene-environment interactions is imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a827948fe5475210aecc62f0f13a4c62
https://pubmed.ncbi.nlm.nih.gov/10070812