Glucose-free/high-protein diet improves hepatomegaly and exercise intolerance in glycogen storage disease type III mice

Autor: Raffaella Violano, Francesco Fortunato, Giacomo P. Comi, Gianna Ulzi, Sabrina Lucchiari, Serena Pagliarani, Andreina Bordoni, Stefania Corti, Nereo Bresolin, Maurizio Moggio, Michela Ripolone

Publikováno v: Biochimica et Biophysica Acta

Glycogen disease type III (GSDIII), a rare incurable autosomal recessive disorder due to glycogen debranching enzyme deficiency, presents with liver, heart and skeletal muscle impairment, hepatomegaly and ketotic hypoglycemia. Muscle weakness usually

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209545d049691221a9d708ab5443d263
https://doi.org/10.1016/j.bbadis.2018.07.031

Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice

Autor: Andras Franko, Hans-Ulrich Häring, Marketa Kovarova, Eckhard Wolf, Annette Feuchtinger, Jan Rozman, Helmut Fuchs, Frauke Neff, Laura Brachthäuser, Birgit Rathkolb, Susanne Neschen, Michaela Aichler, Andreas Peter, Martin Hrabě de Angelis

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 3, Pp 256-266 (2017)
Mol. Metab. 6, 256-266 (2017)

Objective Recently, we have shown that Bezafibrate (BEZ), the pan-PPAR (peroxisome proliferator-activated receptor) activator, ameliorated diabetes in insulin deficient streptozotocin treated diabetic mice. In order to study whether BEZ can also impr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b978b4c0d5931dd73645b5c13e5f62ec
http://europepmc.org/articles/PMC5323884

Imaging and immunometabolic phenotyping uncover changes in the hepatic immune response in the early phases of NAFLD

Autor: Rafael M. Rezende, Juliana A. S. Gomes, Luciana C. Faria, Cristiano Xavier Lima, Maísa Mota Antunes, Ariane Barros Diniz, Mateus Eustáquio Lopes, Débora Romualdo Lacerda, Camila Dutra Moreira de Miranda, Hortência Maciel de Castro-Oliveira, Adaliene Versiane Matos Ferreira, Débora Moreira Alvarenga, Claudia Alves Couto, Tereza Cristina Minto Fontes Cal, Matheus Silvério Mattos, Matthew Ricci, Brenda Naemi Nakagaki, Bruna Araújo David, Kassiana Mafra, Raquel Carvalho-Gontijo, Mônica Morais Santos, Sridhar Radhakrishnnan, André G. Oliveira, Gustavo B. Menezes, Karen Costa, Érika de Carvalho, Maria Alice Freitas Lopes, Alan Moreira de Araujo, Paula Vieira Teixeira Vidigal, Sarah Cozzer Marchesi, Viviane Aparecida de Souza Lacerda, Bruna Roque de Souza

Publikováno v: JHEP Reports, Vol 2, Iss 4, Pp 100117-(2020)
JHEP Reports

Background & Aims The precise determination of non-alcoholic fatty liver disease (NAFLD) onset is challenging. Thus, the initial hepatic responses to fat accumulation, which may be fundamental to our understanding of NAFLD evolution and clinical outc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3713a751be0ec2e38f6af369ad3195f2
https://doi.org/10.1016/j.jhepr.2020.100117

AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice

Autor: Lionel Carneiro, François R Jornayvaz, Christine Sempoux, Corinne Leloup, Jean-Christophe Stehle, Mohamed Asrih, Luc Pellerin, Cendrine Repond

Publikováno v: Molecular metabolism, vol. 6, no. 12, pp. 1625-1633
Molecular Metabolism, Vol. 6, No 12 (2017) pp. 1625-1633
Molecular Metabolism, Vol 6, Iss 12, Pp 1625-1633 (2017)
Molecular metabolism
Molecular metabolism, Elsevier, 2017, 6 (12), pp.1625-1633. ⟨10.1016/j.molmet.2017.10.005⟩
Molecular Metabolism 12 (6), 1625-1633. (2017)
Molecular metabolism, Elsevier, 2017, 6 (12), pp.1625-1633. 〈10.1016/j.molmet.2017.10.005〉
Molecular Metabolism

Objective Hepatic steatosis is the first step leading to non-alcoholic fatty liver disease, which represents a major complication of obesity. Here, we show that MCT1 haploinsufficient mice resist to hepatic steatosis development when fed a high fat d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845a9eee5fd517d81211c0a9c97bf132
https://serval.unil.ch/notice/serval:BIB_1E26E53BF1FE

Lipomodulatory and anti-oxidative stress effects of a polyherbal formulation based on garlic and avocado seed extracts on high fat high sucrose diet fed rats.

Autor: Azantsa BKG; Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, PO Box: 812, Yaounde, Cameroon., Raissa NF; Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, PO Box: 812, Yaounde, Cameroon.; Department of Life and Earth Science, Higher Teachers' Training College, PO Box: 55, Maroua, Cameroon., Mary-Ann MA; Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, PO Box: 812, Yaounde, Cameroon., Amelie M; Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, PO Box: 812, Yaounde, Cameroon., Alexine K; Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, PO Box: 812, Yaounde, Cameroon., Cliffbrown M; Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, PO Box: 812, Yaounde, Cameroon., Lauriane CN; Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, PO Box: 812, Yaounde, Cameroon., Martin F; Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, PO Box: 812, Yaounde, Cameroon., Ferdinand EE; Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, PO Box: 812, Yaounde, Cameroon.; Centre for Food and Nutrition Research, Institute of Medical Research and Medicinal Plant Studies, MINRESI, P.O Box 13033, Yaounde, Cameroon., Laure NJ; Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, PO Box: 812, Yaounde, Cameroon., Oben JE; Laboratory of Nutrition and Nutritional Biochemistry, Department of Biochemistry, Faculty of Sciences, University of Yaounde 1, PO Box: 812, Yaounde, Cameroon.

Publikováno v: Metabolism open [Metabol Open] 2022 Jun 14; Vol. 15, pp. 100195. Date of Electronic Publication: 2022 Jun 14 (Print Publication: 2022).