The biology of SCUBE

Autor: Yuh-Charn Lin, Binay K. Sahoo, Shiang-Shin Gau, Ruey-Bing Yang

Publikováno v: Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-45 (2023)

Abstract The SCUBE [Signal peptide-Complement C1r/C1s, Uegf, Bmp1 (CUB)-Epithelial growth factor domain-containing protein] family consists of three proteins in vertebrates, SCUBE1, 2 and 3, which are highly conserved in zebrafish, mice and humans. E

Externí odkaz: https://doaj.org/article/b52024e455b7427fa2080156215784c8

The Multifaceted Role of Signal Peptide-CUB-EGF Domain-Containing Protein (SCUBE) in Cancer

Autor: Shashank Kumar, Kumari Sunita Prajapati, Sanjay Gupta

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 18, p 10577 (2022)

Signal peptide, CUB, and EGF-like domain-containing proteins (SCUBE) are secretory cell surface glycoproteins that play key roles in the developmental process. SCUBE proteins participate in the progression of several diseases, including cancer, and a

Externí odkaz: https://doaj.org/article/279bb2ed7ef84bb6914feed100d079e0

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling

Autor: Lin, Y.C., Niceta, M., Muto, V., Vona, B., Pagnamenta, A.T., Maroofian, R., Beetz, C., Duyvenvoorde, H. van, Dentici, M.L., Lauffer, P., Vallian, S., Ciolfi, A., Pizzi, S., Bauer, P., Gruning, N.M., Bellacchio, E., Fattore, A. del, Petrini, S., Shaheen, R., Tiosano, D., Halloun, R., Pode-Shakked ben, Albayrak, H.M., Isik, E., Wit, J.M., Dittrich, M., Freire, B.L., Bertola, D.R., Jorge, A.A.L., Barel, O., Sabir, A.H., Tenaiji, A.M.J. al, Taji, S.M., Al-Sannaa, N., Al-Abdulwahed, H., Digilio, M.C., Irving, M., Anikster, Y., Bhavani, G.S.L., Girisha, K.M., Haaf, T., Taylor, J.C., Dallapiccola, B., Alkuraya, F.S., Yang, R.B., Tartaglia, M., Genomics England Res Consortium

Publikováno v: American Journal of Human Genetics, 108(1), 115-133. CELL PRESS
American journal of human genetics, 108(1), 115-133. Cell Press
Am J Hum Genet

Summary Signal peptide-CUB-EGF domain-containing protein 3 (SCUBE3) is a member of a small family of multifunctional cell surface-anchored glycoproteins functioning as co-receptors for a variety of growth factors. Here we report that bi-allelic inact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3485b0a21a8d7dc54b6eb09e83fac7aa
https://hdl.handle.net/1887/3195923

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.