Zobrazeno 1 - 10
of 307
pro vyhledávání: '"SCNA"'
Autor:
Anna S. Vetchinova, Marina R. Kapkaeva, Mikhail V. Ivanov, Kristina A. Kutukova, Natalia M. Mudzhiri, Lydia E. Frumkina, Anatoly V. Brydun, Vladimir S. Sukhorukov, Sergey N. Illarioshkin
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 10, Pp 8395-8411 (2023)
Parkinson’s disease (PD) is the second most common neurodegenerative disease. Some cases of PD may be caused by genetic factors, among which mutations in the LRRK2 and SNCA genes play an important role. To develop effective neuroprotective strategi
Externí odkaz:
https://doaj.org/article/92addc3dbffb49a99bb77514da92d9d0
Publikováno v:
Cancer Biology & Medicine, Vol 19, Iss 5, Pp 685-695 (2022)
Objective: Lung cancer is the most common cause of cancer-related deaths worldwide. Somatic copy number alterations (SCNAs) have been used to predict responses to therapies in many cancers, including lung cancer. However, little is known about whethe
Externí odkaz:
https://doaj.org/article/965d3ccebb704637bf40555c415e30a4
Autor:
Ting Yue, Jingjing Li, Manguang Liang, Jiaman Yang, Zhiwen Ou, Shuchen Wang, Wuhua Ma, Dehui Fan
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Background: Gastric cancer (GC) is the second leading cause of cancer-related mortality and the fifth most common cancer worldwide. However, the underlying mechanisms of competitive endogenous RNAs (ceRNAs) in GC are unclear. This study aimed to cons
Externí odkaz:
https://doaj.org/article/875cf5e7fe36407295ec514c815058f3
Akademický článek
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Autor:
Mary E. Kim, Ashley Polski, Liya Xu, Rishvanth K. Prabakar, Chen-Ching Peng, Mark W. Reid, Rachana Shah, Peter Kuhn, David Cobrinik, James Hicks, Jesse L. Berry
Publikováno v:
Cancers, Vol 13, Iss 13, p 3340 (2021)
Aqueous humor (AH) liquid biopsy has been established as a surrogate tumor biopsy for retinoblastoma (RB). Previous AH studies have focused on highly recurrent RB somatic copy number alterations (SCNAs) including gain of 1q, 2p, 6p, and loss of 13q a
Externí odkaz:
https://doaj.org/article/83b62ecbef954b0d8bd7776986597aa0
Akademický článek
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Autor:
Gregory J. Kimmel, Richard J. Beck, Xiaoqing Yu, Thomas Veith, Samuel Bakhoum, Philipp M. Altrock, Noemi Andor
Publikováno v:
PLoS Computational Biology
The phenotypic efficacy of somatic copy number alterations (SCNAs) stems from their incidence per base pair of the genome, which is orders of magnitudes greater than that of point mutations. One mitotic event stands out in its potential to significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fb8b52ed0c04a7a4170d0860c28894
https://hdl.handle.net/21.11116/0000-000C-A258-A21.11116/0000-000C-A25A-8
https://hdl.handle.net/21.11116/0000-000C-A258-A21.11116/0000-000C-A25A-8
Autor:
Liya Xu, Mary E. Kim, Ashley Polski, Rishvanth K. Prabakar, Lishuang Shen, Chen-Ching Peng, Mark W. Reid, Patricia Chévez-Barrios, Jonathan W. Kim, Rachana Shah, Rima Jubran, Peter Kuhn, David Cobrinik, Jaclyn A. Biegel, Xiaowu Gai, James Hicks, Jesse L. Berry
Publikováno v:
Cancers, Vol 13, Iss 6, p 1282 (2021)
Because direct tumor biopsy is prohibited for retinoblastoma (RB), eye-specific molecular biomarkers are not used in clinical practice for RB. Recently, we demonstrated that the aqueous humor (AH) is a rich liquid biopsy source of cell-free tumor DNA
Externí odkaz:
https://doaj.org/article/0c7521c9e71e4c88b71af9d0ef161318
Akademický článek
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Autor:
Slavica Trajkova, Eleonora Di Gregorio, Giovanni Battista Ferrero, Diana Carli, Lisa Pavinato, Geoffroy Delplancq, Paul Kuentz, Alfredo Brusco
Publikováno v:
Brain Sciences, Vol 10, Iss 11, p 788 (2020)
Potocki-Shaffer syndrome (PSS) is a rare non-recurrent contiguous gene deletion syndrome involving chromosome 11p11.2. Current literature implies a minimal region with haploinsufficiency of three genes, ALX4 (parietal foramina), EXT2 (multiple exosto
Externí odkaz:
https://doaj.org/article/201bad60a79a48afbfa42430bbd52181