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Elongation factor-specific capture of RNA polymerase II complexes

Autor: Lea H. Gregersen, Richard Mitter, Jesper Q. Svejstrup

Publikováno v: Gregersen, L H, Mitter, R & Svejstrup, J Q 2022, ' Elongation factor-specific capture of RNA polymerase II complexes ', Cell Reports Methods, vol. 2, no. 12, 100368 . https://doi.org/10.1016/j.crmeth.2022.100368

Transcription of protein-coding genes is regulated by dynamic association of co-factors with RNA polymerase II (RNAPII). The function of these factors and their relationship with RNAPII is often poorly understood. Here, we present an approach for elo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d46a8a6bce2849ef1e50c853fdff21d

Heat shock induces premature transcript termination and reconfigures the human transcriptome

Autor: Simona Cugusi, Richard Mitter, Gavin P. Kelly, Jane Walker, Zhong Han, Paola Pisano, Michael Wierer, Aengus Stewart, Jesper Q. Svejstrup

Publikováno v: Cugusi, S, Mitter, R, Kelly, G P, Walker, J, Han, Z, Pisano, P, Wierer, M, Stewart, A & Svejstrup, J Q 2022, ' Heat shock induces premature transcript termination and reconfigures the human transcriptome ', Molecular Cell, vol. 82, no. 8, pp. 1573-1588.e10 . https://doi.org/10.1016/j.molcel.2022.01.007

The heat shock (HS) response involves rapid induction of HS genes, whereas transcriptional repression is established more slowly at most other genes. Previous data suggested that such repression results from inhibition of RNA polymerase II (RNAPII) p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3791b8e421bee82b22d02a1732ed817e
https://curis.ku.dk/portal/da/publications/heat-shock-induces-premature-transcript-termination-and-reconfigures-the-human-transcriptome(ef04157d-7665-46bf-a846-5be197ecd524).html

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Variants in SCAF4 Cause a Neurodevelopmental Disorder and Are Associated with Impaired mRNA Processing

Autor: Grace J. Noh, Marjon van Slegtenhorst, Ingrid M.B.H. van de Laar, Lisa Ohden, Joshua L. Deignan, Jane Juusola, Naghmeh Dorrani, Katherine Agre, Anne Gregor, Vidya Krishnamurthy, Arif B. Ekici, Julian A. Martinez-Agosto, Vimla Aggarwal, T. Niroshi Senaratne, Seema R. Lalani, Antje Wiesener, Stella A. de Man, Mahshid S. Azamian, Marina S. Dutra-Clarke, Jill A. Rosenfeld, Ahna M. Neustadt, Daryl A. Scott, Brent L. Fogel, Stanley F. Nelson, Ghayda M. Mirzaa, Irma van de Beek, Kirsty McWalter, Wayne W. Grody, Rachel Straussberg, Ralitza H. Gavrilova, Hane Lee, Anna Fliedner, Quinten Waisfisz, Mieke M. van Haelst, Jessica Kianmahd, Fabiola Quintero-Rivera, Marina Dutra-Clarke, Rony Cohen, Laura Davis-Keppen, Anna Alkelai, Christiane Zweier, Fan Xia, Brooke Horist, Philipp Kirchner, Sung-Hae Kang, Franceska L. Hinkamp, Natalie Lippa, Valerie A. Arboleda

Publikováno v: Fliedner, A, Kirchner, P, Wiesener, A, van de Beek, I, Waisfisz, Q, van Haelst, M, Scott, D A, Lalani, S R, Rosenfeld, J A, Azamian, M S, Xia, F, Dutra-Clarke, M, Martinez-Agosto, J A, Lee, H, Noh, G J, Lippa, N, Alkelai, A, Aggarwal, V, Agre, K E, Gavrilova, R, Mirzaa, G M, Straussberg, R, Cohen, R, Horist, B, Krishnamurthy, V, McWalter, K, Juusola, J, Davis-Keppen, L, Ohden, L, van Slegtenhorst, M, de Man, S A, Ekici, A B, Gregor, A, van de Laar, I, Zweier, C & UCLA Clinical Genomics Center 2020, ' Variants in SCAF4 Cause a Neurodevelopmental Disorder and Are Associated with Impaired mRNA Processing ', American journal of human genetics, vol. 107, no. 3, pp. 544-554 . https://doi.org/10.1016/j.ajhg.2020.06.019
American journal of human genetics, 107(3), 544-554. Cell Press
Am J Hum Genet
American Journal of Human Genetics, 107(3), 544-554. Cell Press

RNA polymerase II interacts with various other complexes and factors to ensure correct initiation, elongation, and termination of mRNA transcription. One of these proteins is SR-related CTD-associated factor 4 (SCAF4), which is important for correct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9417770654c6a8fcc91fcdc725972c10
https://research.vumc.nl/en/publications/f7f8dc41-7e52-465b-b68c-c1218ff2d478