Abstract 2653: Lineage plasticity in small cell lung cancer generates non- neuroendocrine cells primed for vascular mimicry

Autor: Melanie Galvin, Fiona H Blackhall, Martin J. Humphries, Alastair R.W. Kerr, Sarah M. Pearsall, Lynsey Priest, Gregory Hannon, Fernando Jose Garcia Marques, Julien Sage, Sharon J. Pitteri, Ian Cannell, Jonathon D. Humphries, SC Williamson, Ellyn Hughes, Sam Humphrey, Caroline Dive, Kathryn Simpson, Mathew Carter, Kristopher K. Frese

Publikováno v: Cancer Research. 81:2653-2653

Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine (NE) cancer with rapid and widespread metastasis and a dismal prognosis measurable only in months. The inherent lack of tumor biopsies has limited our understanding of SCLC phenotypi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6dee6b95d873de751beaf808a467b29c
https://doi.org/10.1158/1538-7445.am2021-2653

Tumourigenic non-small-cell lung cancer mesenchymal circulating tumour cells: a clinical case study

Autor: L. Frankliln, Crispin J. Miller, Robert Metcalf, Fiona H Blackhall, SC Williamson, Garima Khandelwal, Kathryn Simpson, Kristopher K. Frese, Nicole Simms, Cassandra L Hodgkinson, Melanie Galvin, Daisuke Nonaka, Caroline Dive, Louise Carter, Paul P. Kelly, Christopher J. Morrow, Francesca Trapani, Gerard Brady, Dominic G. Rothwell, Christopher Wirth, Giulia Bertolini

Publikováno v: Annals of Oncology

An explant model derived from EpCam negative mesenchymal non-small-cell lung (NSCLC) cancer circulating tumour cells (a ‘liquid biopsy’) recapitulates the histology of the donor patient's diagnostic specimen and chemoresistance to cisplatin and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01e38e86746d8e258b72b761c1ae5bf
https://doi.org/10.1093/annonc/mdw122

Characterisations of human prostate stem cells reveal deficiency in class I UGT enzymes as a novel mechanism for castration-resistant prostate cancer

Autor: Laura Wilson, Anastasia C. Hepburn, Alejandra Mantilla, Richard Mitter, Craig N. Robson, Hing Y. Leung, SC Williamson, Rakesh Heer

Publikováno v: British Journal of Cancer

Mechanistic studies of tumorigenesis point towards stem cells (SCs) being the cell of origin in prostate cancer initiation, suggesting stem pathways have a crucial role in the early stages of cancer development (Gu et al, 2007; Goldstein et al, 2010;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711dc12f1c5a62edf92034ec9e066b03
https://doi.org/10.1038/bjc.2013.399

BAUS Section of Academic Urology Paper Presentations

Autor: M Moad, Deepali Pal, SC Williamson, Anastasia C. Hepburn, Rakesh Heer, MK Kanani, Luke Gaughan, Craig N. Robson

Publikováno v: British Journal of Surgery. 100:63-70

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07af9019047958d861878a1c40caaa6d
https://doi.org/10.1002/bjs.9142

Vasculogenic mimicry in small cell lung cancer

Autor: Christopher P. E. Chester, Hui Sun Leong, Nicole Simms, Peter Kuhn, Lynsey Priest, Fiona H Blackhall, Alberto Fusi, Sumitra Mohan, Benjamin Abbott, Mary J.C. Hendrix, Ged Brady, Richard E.B. Seftor, Radoslaw Polanski, Anders Carlsson, Fredrika Carlsson, Robert Metcalf, Elisabeth A. Seftor, Francesca Trapani, SC Williamson, Caroline Dive, Jenny Antonello, Andrew Hughes, Kathryn Simpson, Daisuke Nonaka, Crispin J. Miller, Dominic G. Rothwell, James W. Hicks

Publikováno v: Williamson, S C, Metcalf, R L, Trapani, F, Mohan, S, Antonello, J, Abbott, B, Leong, H S, Chester, C, Simms, N, Polanski, R, Nonaka, D, Priest, L, Fusi, A, Carlsson, F, Carlsson, A, Hendrix, M J C, Seftor, R E B, Seftor, E A, Rothwell, D G, Hughes, A, Hicks, J, Miller, C, Kuhn, P, Brady, G, Simpson, K L, Blackhall, F H & Dive, C 2016, ' Vasculogenic mimicry in small cell lung cancer ', Nature Communications, vol. 7, pp. 13322 . https://doi.org/10.1038/ncomms13322, https://doi.org/10.1038/ncomms13322
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Trapani, F, Metcalf, R L, Hodgkinson, C L, Polanski, R, Bola, B, Nonaka, D, Fusi, A, Priest, L, Hendrix, M J C, Seftor, R E B, Seftor, E A, Morrow, C J, Antonello, J, Brady, G, Miller, C, Leong, H S, Rothwell, D, Blackhall, F, Williamson, S, Dive, C & Simpson, K L 2015, ' Vasculogenic Mimicry in Small Cell Lung Cancer ', Journal of Thoracic Oncology, vol. 10, no. 9 . https://doi.org/10.1038/ncomms13322

Small cell lung cancer (SCLC) is characterized by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. We show that SCLC patients (37/38) have rare CTC subpopulations co-expressing vascular endothelial-cadherin (VE-cadherin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59b365016485bf0cea596e73fed88594
https://doi.org/10.1038/ncomms13322