Abstract 13875: Torsade de Pointes Arrhythmias Arise at the Site of Maximal Heterogeneity of Repolarization in the Chronic Complete AV-block Dog

Autor: A Dunnink, TRG Stams, HDM Beekman, A Bossu, SC Wijers, VMF Meijborg, JMT de Bakker, MA Vos

Publikováno v: Circulation. 132

Introduction: The chronic complete atrioventricular block (CAVB) dog model is highly sensitive for drug-induced Torsade de Pointes (TdP) arrhythmias. Focal mechanisms have been considered as trigger for the onset of TdP, however, its exact mechanism

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https://doi.org/10.1161/circ.132.suppl_3.13875

Evaluation of a Fully Automatic Measurement of Short-Term Variability of Repolarization on Intracardiac Electrograms in the Chronic Atrioventricular Block Dog.

Autor: Smoczyńska A; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Sprenkeler DJ; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Aranda A; Medtronic Bakken Research Center, Maastricht, Netherlands., Beekman JDM; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Bossu A; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Dunnink A; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Wijers SC; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands., Stegemann B; Medtronic Bakken Research Center, Maastricht, Netherlands., Meine M; Department of Cardiology, University Medical Center Utrecht, Utrecht, Netherlands., Vos MA; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands.

Publikováno v: Frontiers in physiology [Front Physiol] 2020 Aug 21; Vol. 11, pp. 1005. Date of Electronic Publication: 2020 Aug 21 (Print Publication: 2020).

Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy.

Autor: Bergau L; University Medical Center Göttingen, Dept. of Cardiology and Pneumology, Göttingen, Germany., Willems R; University Hospitals of Leuven, Leuven, Belgium., Sprenkeler DJ; University Medical Center Utrecht, Dept. of Medical Physiology, Utrecht, Netherlands., Fischer TH; University Medical Center Göttingen, Dept. of Cardiology and Pneumology, Göttingen, Germany., Flevari P; Attikon University Hospital, Dept. of Cardiology, Athens, Greece., Hasenfuß G; University Medical Center Göttingen, Dept. of Cardiology and Pneumology, Göttingen, Germany; DZHK (German Center for Cardiovascular Research), partner site Göttingen, Göttingen, Germany., Katsaras D; Attikon University Hospital, Dept. of Cardiology, Athens, Greece., Kirova A; University Medical Center Göttingen, Dept. of Cardiology and Pneumology, Göttingen, Germany., Lehnart SE; University Medical Center Göttingen, Dept. of Cardiology and Pneumology, Göttingen, Germany; DZHK (German Center for Cardiovascular Research), partner site Göttingen, Göttingen, Germany., Lüthje L; University Medical Center Göttingen, Dept. of Cardiology and Pneumology, Göttingen, Germany., Röver C; University Medical Center Göttingen, Dept. of Medical Statistics, Göttingen, Germany., Seegers J; University Medical Center Göttingen, Dept. of Cardiology and Pneumology, Göttingen, Germany; Division of Cardiology, Dept. of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany., Sossalla S; University Medical Center Göttingen, Dept. of Cardiology and Pneumology, Göttingen, Germany; Division of Cardiology, Dept. of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany., Dunnink A; University Medical Center Utrecht, Dept. of Medical Physiology, Utrecht, Netherlands., Sritharan R; University Medical Center Göttingen, Dept. of Cardiology and Pneumology, Göttingen, Germany., Tuinenburg AE; University Medical Center Utrecht, Dept. of Cardiology, Utrecht, Netherlands., Vandenberk B; University Hospitals of Leuven, Leuven, Belgium., Vos MA; University Medical Center Utrecht, Dept. of Medical Physiology, Utrecht, Netherlands., Wijers SC; University Medical Center Utrecht, Dept. of Medical Physiology, Utrecht, Netherlands; University Medical Center Utrecht, Dept. of Cardiology, Utrecht, Netherlands., Friede T; DZHK (German Center for Cardiovascular Research), partner site Göttingen, Göttingen, Germany; University Medical Center Göttingen, Dept. of Medical Statistics, Göttingen, Germany., Zabel M; University Medical Center Göttingen, Dept. of Cardiology and Pneumology, Göttingen, Germany; DZHK (German Center for Cardiovascular Research), partner site Göttingen, Göttingen, Germany. Electronic address: markus.zabel@med.uni-goettingen.de.

Publikováno v: International journal of cardiology [Int J Cardiol] 2018 Dec 01; Vol. 272, pp. 102-107. Date of Electronic Publication: 2018 Jun 28.

Beat-to-beat variations in activation-recovery interval derived from the right ventricular electrogram can monitor arrhythmic risk under anesthetic and awake conditions in the canine chronic atrioventricular block model.

Autor: Wijers SC; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands., Sprenkeler DJ; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands., Bossu A; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands., Dunnink A; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands., Beekman JDM; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands., Varkevisser R; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands., Hernández AA; Medtronic Bakken Research Center, Maastricht, The Netherlands., Meine M; Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands., Vos MA; Department of Medical Physiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: m.a.vos@umcutrecht.nl.

Publikováno v: Heart rhythm [Heart Rhythm] 2018 Mar; Vol. 15 (3), pp. 442-448. Date of Electronic Publication: 2017 Nov 13.

Torsade de pointes arrhythmias arise at the site of maximal heterogeneity of repolarization in the chronic complete atrioventricular block dog.

Autor: Dunnink A; Department of Medical Physiology, University Medical Center Utrecht, Yalelaan 50, Utrecht 3584 CM, The Netherlands., Stams TRG; Department of Medical Physiology, University Medical Center Utrecht, Yalelaan 50, Utrecht 3584 CM, The Netherlands., Bossu A; Department of Medical Physiology, University Medical Center Utrecht, Yalelaan 50, Utrecht 3584 CM, The Netherlands., Meijborg VMF; Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands., Beekman JDM; Department of Medical Physiology, University Medical Center Utrecht, Yalelaan 50, Utrecht 3584 CM, The Netherlands., Wijers SC; Department of Medical Physiology, University Medical Center Utrecht, Yalelaan 50, Utrecht 3584 CM, The Netherlands., De Bakker JMT; Department of Medical Physiology, University Medical Center Utrecht, Yalelaan 50, Utrecht 3584 CM, The Netherlands.; Department of Clinical and Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.; Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands., Vos MA; Department of Medical Physiology, University Medical Center Utrecht, Yalelaan 50, Utrecht 3584 CM, The Netherlands.

Publikováno v: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology [Europace] 2017 May 01; Vol. 19 (5), pp. 858-865.