Tumor cells exhibit deregulation of the cell cycle histone gene promoter factor HiNF-D

Autor: J Holthuis, TA Owen, AJ van Wijnen, KL Wright, A Ramsey-Ewing, MB Kennedy, R Carter, SC Cosenza, KJ Soprano, JB Lian, al. et

Publikováno v: Science. 247:1454-1457

Cell cycle-regulated gene expression is essential for normal cell growth and development and loss of stringent growth control is associated with the acquisition of the transformed phenotype. The selective synthesis of histone proteins during the S ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b0150d3f74031c73f3071d6655fc37
https://doi.org/10.1126/science.247.4949.1454

Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease.

Autor: Sato K; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Padgaonkar AA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Baker SJ; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cosenza SC; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Rechkoblit O; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Subbaiah DRCV; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Domingo-Domenech J; Medical Oncology and Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA., Bartkowski A; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Port ER; Department of Surgery, Mount Sinai Hospital, New York, NY, USA., Aggarwal AK; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ramana Reddy MV; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Irie HY; Division of Hematology and Medical Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. hanna.irie@mssm.edu.; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. hanna.irie@mssm.edu., Reddy EP; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ep.reddy@mssm.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Aug 03; Vol. 12 (1), pp. 4671. Date of Electronic Publication: 2021 Aug 03.

Rigosertib ameliorates the effects of oncogenic KRAS signaling in a murine model of myeloproliferative neoplasia.

Autor: Baker SJ; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Cosenza SC; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ramana Reddy MV; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Premkumar Reddy E; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Publikováno v: Oncotarget [Oncotarget] 2019 Mar 08; Vol. 10 (20), pp. 1932-1942. Date of Electronic Publication: 2019 Mar 08 (Print Publication: 2019).

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.

Autor: Athuluri-Divakar SK; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Vasquez-Del Carpio R; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Dutta K; New York Structural Biology Center, 89 Convent Avenue, New York, NY 10027, USA., Baker SJ; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Cosenza SC; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Basu I; Department of Radiation Oncology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA., Gupta YK; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Reddy MV; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Ueno L; The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Hart JR; The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Vogt PK; The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA., Mulholland D; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Guha C; Department of Radiation Oncology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA., Aggarwal AK; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA., Reddy EP; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029, USA. Electronic address: ep.reddy@mssm.edu.

Publikováno v: Cell [Cell] 2016 Apr 21; Vol. 165 (3), pp. 643-55.

Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas.

Autor: Divakar SK; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ramana Reddy MV; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cosenza SC; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Baker SJ; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Perumal D; Department of Hematology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Antonelli AC; Department of Hematology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Brody J; Department of Hematology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Akula B; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Parekh S; Department of Hematology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Reddy EP; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Structural Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Publikováno v: Leukemia [Leukemia] 2016 Jan; Vol. 30 (1), pp. 86-93. Date of Electronic Publication: 2015 Jul 15.