Výsledky vyhledávání - "SC, subcutaneous"

A multidisciplinary approach to optimizing care of patients treated with alpelisib

Autor: Rugo, Hope S., Lacouture, Mario E., Goncalves, Marcus D., Masharani, Umesh, Aapro, Matti S., O'Shaughnessy, Joyce A.

Publikováno v: Breast, Vol 61, Iss, Pp 156-167 (2022)
The Breast : Official Journal of the European Society of Mastology

Purpose The oral, α-specific phosphatidylinositol-3-kinase (PI3Kα) inhibitor alpelisib is the first PI3K inhibitor approved for the treatment of advanced breast cancer. As alpelisib is a relatively new therapeutic option, specific guidance and a mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed100c67c3edaa21648be43be27980e
https://doi.org/10.1016/j.breast.2021.12.016

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Prolonged efavirenz exposure reduces peripheral oxytocin and vasopressin comparable to known drugs of addiction in male Sprague Dawley rats

Autor: Brian H. Harvey, Mandi Le Roux, Marisa Möller

Publikováno v: IBRO Neuroscience Reports
IBRO Neuroscience Reports, Vol 11, Iss, Pp 56-63 (2021)

Introduction Several drugs of abuse (DOA) are capable of modulating neurohypophysial hormones, such as oxytocin (OT) and vasopressin (VP), potentially resulting in the development of psychological abnormalities, such as cognitive dysfunction, psychos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae39fff547757f79eb2dc60aa152677e
https://doi.org/10.1016/j.ibneur.2021.06.003

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Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Autor: Yi Lu, Zhongjian Chen, Wei Wu, Pijush Kumar Paul, Quangang Zhu, Jianping Qi

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2416-2448 (2021)

Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6732d4326595a5ad29955ebaff92173
https://doi.org/10.1016/j.apsb.2021.04.001

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Self-assembled mRNA vaccines

Autor: Yulia Eygeris, Gaurav Sahay, Mohit Gupta, Jeonghwan Kim

Publikováno v: Advanced Drug Delivery Reviews

mRNA vaccines have evolved from being a mere curiosity to emerging as COVID-19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology, and nanotechnology have generated interest in delivering safe and effective mRNA th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0f88a1e945504ba8b4af825e8da083
https://doi.org/10.1016/j.addr.2020.12.014

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A novel compound heterozygous leptin receptor mutation causes more severe obesity than in Lepr

Autor: Claudia Berger, Matthias Blüher, Janet Kelso, Nora Klöting, Henrike O. Heyne, Esther Guiu-Jurado, Tina Heiland, Peter Kovacs, Sebastian Dommel, Steffen Roßner, Michael Dannemann, Corinna Höfling, Jana Lorenz

Publikováno v: Journal of Lipid Research
J. Lipid Res. 62:100105 (2021)
Journal of Lipid Research, Vol 62, Iss, Pp 100105-(2021)

The leptin receptor (Lepr) pathway is important for food intake regulation, energy expenditure and body weight. Mutations in leptin and the Lepr have been shown to cause early-onset severe obesity in mice and humans. In studies with C57BL/6NCrl mice,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27187f8e7883d9974250f02e58c65888
https://pubmed.ncbi.nlm.nih.gov/34390703

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Clinical features and medical care factors associated with mortality in French nursing homes during the COVID-19 outbreak

Autor: Julien Berthaud, Coralie Noel, Alessio Strazzulla, Sebastien Jochmans, Sylvain Diamantis, Zine-Eddine Benguerdi, Maxence Rouyer, Guillaume Bardin, Manuel Hommel, Paul Tarteret, Cecile Gore, Sylvie Aufaure

Publikováno v: International Journal of Infectious Diseases
International Journal of Infectious Diseases, Vol 104, Iss, Pp 125-131 (2021)

Highlights • Among nursing homes with COVID-19 cases, mortality rates are highly variable. • Hospital dependent nursing homes are associated with lower mortality rates. • Increased material, human and medical resources reduce mortality in nursi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69ac92feba439e0f0eb53725c8cdcb0

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A review of existing strategies for designing long-acting parenteral formulations: Focus on underlying mechanisms, and future perspectives

Autor: Xiangyu Wang, An Lu, Qiang Zhang, Zakia Belhadj, Yujie Shi, Jiancheng Wang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2396-2415 (2021)

The need for long-term treatments of chronic diseases has motivated the widespread development of long-acting parenteral formulations (LAPFs) with the aim of improving drug pharmacokinetics and therapeutic efficacy. LAPFs have been proven to extend t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ae988908ab95b495e6190ff9a49114
https://pubmed.ncbi.nlm.nih.gov/34522592

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