Výsledky vyhledávání - "SATORU MOTOYOSHI"

A Useful Method for Differential Evaluation of Anti-Inflammatory Effects Due to Cyclooxygenase and 5-Lipoxygenase Inhibitions in Mice

Autor: Hiroyo Nakagawa, Kunihiko Takeyama, Katsumi Ishii, Satoru Motoyoshi, Joe Kawata

Publikováno v: Japanese Journal of Pharmacology. 65:297-303

This study was performed to establish a useful method for monitoring the effects of inhibitors of 5-lipoxygenase (5-LO) and/or cyclooxygenase (CO) and for differential evaluation of these inhibitors. After oral dosing, CO inhibitors such as indometha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e87737a3b0fef51d62ff0e18cbd518
https://doi.org/10.1254/jjp.65.297

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Effect of Shikonin and Its Derivatives Pentaacetylated Shikonin (MDS-004) on Granuloma Formation and Delayed-Type Allergy in Experimental Animals

Autor: Junichi Imuta, Satoru Motoyoshi, Shigeru Isayama, Yasuhiro Seto, Hideo Nakamura, Takeshi Ishitoku

Publikováno v: YAKUGAKU ZASSHI. 112:259-271

Of twelve reduced and acetylated derivatives of shikonin, a chemical constituent of Shikon, the accelerating activity on granuloma formation and the inhibitory activity on delayed-type allergy were investigated in order to find a compound having more

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65041c1e26da08467049735c1c5156d4
https://doi.org/10.1248/yakushi1947.112.4_259

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Inhibition of leukotriene production by N-[4-[4-(diphenylmethyl)-1- piperazinyl]butyl]-3-(6-methyl-3-pyridyl) acrylamide (AL-3264), a new antiallergic agent

Autor: Katsumi Ishii, Ikuhisa Yakuo, Satoru Motoyoshi, Hiroyo Nakagawa, Hideo Nakamura

Publikováno v: Japanese journal of pharmacology. 65(1)

The effects of AL-3264, which exhibits a 5-lipoxygenase (5-LO) inhibiting property by blocking histamine H1-receptors and inhibition of histamine release, were examined on leukotriene (LT) production and LT-mediated responses. AL-3264 (1-30 microM) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f3980ece4d09968795b7a56fb78d02
https://pubmed.ncbi.nlm.nih.gov/7916384

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Inhibition of prostaglandin generation in the rabbit brain in-vivo by AD-1590, a non-steroidal antiinflammatory agent with potent antipyretic activity

Autor: Yuichi Yokoyama, Yasuhiro Seto, Hideo Nakamura, Masanao Shimizu, Toshiaki Kadokawa, Satoru Motoyoshi

Publikováno v: Journal of Pharmacy and Pharmacology. 37:894-898

The inhibition of prostaglandin generation by AD-1590 was investigated in the rabbit brain in-vivo. AD-1590 (0ṁ4 mg kg−1 i.v.) markedly prevented both the increases in body temperature and PGE2 level in cerebrospinal fluid (CSF) caused by i.v. in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954856bf33187cd704fe9961c9c20ac8
https://doi.org/10.1111/j.2042-7158.1985.tb04996.x

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A correlation between the species differences in anti-inflammatory activity of AD-1590, a non-steroidal anti-inflammatory drug, and its plasma level

Autor: Yuichi Yokoyama, Satoru Motoyoshi, Toshiaki Kadokawa, Hideo Nakamura, Yasuhiro Seto

Publikováno v: Folia Pharmacologica Japonica. 91:393-399

Authors have reported that the oral potency ratio of AD-1590 to indomethacin varies with the animal models employed; the ratio is 4, 2.3 and 31 in the tests of acetic acid-induced vascular permeability (male mice), carrageenan hind paw edema (male ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96eb70f652490622b09b2d5b66e0a81
https://doi.org/10.1254/fpj.91.393

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