TNF-α inhibits SATB2 expression and osteoblast differentiation through NF-κB and MAPK pathways

Autor: Xiaoying Zhao, Ning Zhang, Jiake Xu, Guoli Hu, Yu Shi, Wen Wu, Chuandong Wang, Xiaoling Zhang, Chijian Zuo

Publikováno v: Oncotarget

Although the mechanisms of Tumor necrosis factor alpha (TNF-α) on facilitating osteoclast differentiation and bone resorption is well known, the mechanisms behind the suppression of the osteoblast differentiation from mesenchymal stem cells (MSCs) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ca4a7387278f04c4c06a9c99f000cd
https://doi.org/10.18632/oncotarget.23373

TNF-α inhibits SATB2 expression and osteoblast differentiation through NF-κB and MAPK pathways.

Autor: Zuo C; Department of Orthopedic Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.; The Key Laboratory of Stem Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China., Zhao X; Department of Orthopedic Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China., Shi Y; The Key Laboratory of Stem Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China., Wu W; Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China., Zhang N; The Key Laboratory of Stem Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China., Xu J; School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Western Australia 6009, Australia., Wang C; Department of Orthopedic Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China., Hu G; Department of Orthopedic Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China., Zhang X; Department of Orthopedic Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.; The Key Laboratory of Stem Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China.

Publikováno v: Oncotarget [Oncotarget] 2017 Dec 18; Vol. 9 (4), pp. 4833-4850. Date of Electronic Publication: 2017 Dec 18 (Print Publication: 2018).