Zobrazeno 1 - 10
of 297
pro vyhledávání: '"SARAH PALMER"'
Autor:
Daniel G. Ferguson, Jessica Abele, Sarah Palmer, Jordan Willis, Connor McDonald, Chandler Messer, Juliana Lindberg, T. Heath Ogden, Elizabeth G. Bailey, Jamie L. Jensen
Publikováno v:
Evolution: Education and Outreach, Vol 15, Iss 1, Pp 1-9 (2022)
Abstract Background Many students enter science classrooms with misconceptions about scientific principles. One of the most perceived controversial scientific principle for students is evolution. Students struggle to learn and accept evolution due to
Externí odkaz:
https://doaj.org/article/89fce8050ac54b49befef66ea076031d
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102025- (2023)
Summary: CD8+ T lymphocytes can recognize and eliminate cells infected by viruses. However, the human immunodeficiency virus (HIV-1) has developed mechanisms to evade CD8+ T-cell-mediated clearance. Here, we describe a protocol to assess the role of
Externí odkaz:
https://doaj.org/article/b0f3d72124a6433f9896fcbf98333942
Autor:
Katie Fisher, Timothy E. Schlub, Zoe Boyer, Thomas A. Rasmussen, Ajantha Rhodes, Rebecca Hoh, Frederick M. Hecht, Steven G. Deeks, Sharon R. Lewin, Sarah Palmer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHIV-1 persists in resting CD4+ T-cells despite antiretroviral therapy (ART). Determining the cell surface markers that enrich for genetically-intact HIV-1 genomes is vital in developing targeted curative strategies. Previous studies have
Externí odkaz:
https://doaj.org/article/8ab70143506b4063b3093bbe3bac76ac
Autor:
Basiel Cole, Laurens Lambrechts, Pierre Gantner, Ytse Noppe, Noah Bonine, Wojciech Witkowski, Lennie Chen, Sarah Palmer, James I. Mullins, Nicolas Chomont, Marion Pardons, Linos Vandekerckhove
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
To provide in depth characterization of HIV reservoir cells, the authors here develop a single-cell approach to simultaneously sequence TCR, integration sites and proviral genomes, called STIP-Seq, and show that the translation-competent reservoir ma
Externí odkaz:
https://doaj.org/article/bb2639ad014b4e8797620272ce98b655
Autor:
Gabriel Duette, Bonnie Hiener, Hannah Morgan, Fernando G. Mazur, Vennila Mathivanan, Bethany A. Horsburgh, Katie Fisher, Orion Tong, Eunok Lee, Haelee Ahn, Ansari Shaik, Rémi Fromentin, Rebecca Hoh, Charline Bacchus-Souffan, Najla Nasr, Anthony L. Cunningham, Peter W. Hunt, Nicolas Chomont, Stuart G. Turville, Steven G. Deeks, Anthony D. Kelleher, Timothy E. Schlub, Sarah Palmer
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 7 (2022)
Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular populations that contribute to the HIV-1 reservoir and understand
Externí odkaz:
https://doaj.org/article/e7d25a389c024bd794a8bffa17580540
Autor:
Jarrod York, Kavitha Gowrishankar, Kenneth Micklethwaite, Sarah Palmer, Anthony L. Cunningham, Najla Nasr
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Although the advent of ART has significantly reduced the morbidity and mortality associated with HIV infection, the stable pool of HIV in latently infected cells requires lifelong treatment adherence, with the cessation of ART resulting in rapid reac
Externí odkaz:
https://doaj.org/article/a1af93c7662f4220b662764d9663f40f
Autor:
Vincent Morcilla, Charline Bacchus-Souffan, Katie Fisher, Bethany A. Horsburgh, Bonnie Hiener, Xiao Qian Wang, Timothy E. Schlub, Mark Fitch, Rebecca Hoh, Frederick M. Hecht, Jeffrey N. Martin, Steven G. Deeks, Marc K. Hellerstein, Joseph M. McCune, Peter W. Hunt, Sarah Palmer
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
The design of future HIV-1 curative therapies requires a more thorough understanding of the distribution of genetically intact HIV-1 within T-cell subsets as well as the cellular mechanisms that maintain this reservoir. These genetically intact and p
Externí odkaz:
https://doaj.org/article/9840134545d946e5afd4453b7f75a3e7
Autor:
John Zaunders, Wayne B. Dyer, Melissa Churchill, C Mee Ling Munier, Philip H. Cunningham, Kazuo Suzuki, Kristin McBride, Will Hey-Nguyen, Kersten Koelsch, Bin Wang, Bonnie Hiener, Sarah Palmer, Paul R. Gorry, Michelle Bailey, Yin Xu, Mark Danta, Nabila Seddiki, David A. Cooper, Nitin K. Saksena, John S. Sullivan, Sean Riminton, Jenny Learmont, Anthony D. Kelleher
Publikováno v:
Journal of Virus Eradication, Vol 5, Iss 2, Pp 73-83 (2019)
Background: Subject C135 is one of the members of the Sydney Blood Bank Cohort, infected in 1981 through transfusion with attenuated nef/3′ long terminal repeat (LTR)-deleted HIV-1, and has maintained undetectable plasma viral load and steady CD4 c
Externí odkaz:
https://doaj.org/article/a27c05d601584cf188222ddab4735ed5
Autor:
Orion Tong, Gabriel Duette, Thomas R O'Neil, Caroline M Royle, Hafsa Rana, Blake Johnson, Nicole Popovic, Suat Dervish, Michelle A E Brouwer, Heeva Baharlou, Ellis Patrick, Grahame Ctercteko, Sarah Palmer, Eunok Lee, Eric Hunter, Andrew N Harman, Anthony L Cunningham, Najla Nasr
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009522 (2021)
Although HIV infection inhibits interferon responses in its target cells in vitro, interferon signatures can be detected in vivo soon after sexual transmission, mainly attributed to plasmacytoid dendritic cells (pDCs). In this study, we examined the
Externí odkaz:
https://doaj.org/article/ac8d0f3bc05e48a0b188ee8f2bad653c
Autor:
Jason Neidleman, Xiaoyu Luo, Julie Frouard, Guorui Xie, Feng Hsiao, Tongcui Ma, Vincent Morcilla, Ashley Lee, Sushama Telwatte, Reuben Thomas, Whitney Tamaki, Benjamin Wheeler, Rebecca Hoh, Ma Somsouk, Poonam Vohra, Jeffrey Milush, Katherine Sholtis James, Nancie M Archin, Peter W Hunt, Steven G Deeks, Steven A Yukl, Sarah Palmer, Warner C Greene, Nadia R Roan
Publikováno v:
eLife, Vol 9 (2020)
The latent reservoir is a major barrier to HIV cure. As latently infected cells cannot be phenotyped directly, the features of the in vivo reservoir have remained elusive. Here, we describe a method that leverages high-dimensional phenotyping using C
Externí odkaz:
https://doaj.org/article/498edfb6f058495dafa1f755ce519293