Zobrazeno 1 - 10
of 87
pro vyhledávání: '"SARAH A. TERSEY"'
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101938- (2023)
Summary: Investigating the immune attack on β cells is critical to understanding autoimmune diabetes. Here, we present a protocol to isolate immune cells from mouse pancreatic lymph nodes and whole pancreas, followed by mass cytometric analyses. Thi
Externí odkaz:
https://doaj.org/article/7aa06b80963f44238fcbb5c634fb18de
Autor:
Deepika Dhawan, José A. Ramos-Vara, Sagar M. Utturkar, Audrey Ruple, Sarah A. Tersey, Jennifer B. Nelson, Bruce R. Cooper, Hock Gan Heng, Elaine A. Ostrander, Heidi G. Parker, Noah M. Hahn, Larry G. Adams, Christopher M. Fulkerson, Michael O. Childress, Patty L. Bonney, Christine Royce, Lindsey M. Fourez, Alexander W. Enstrom, Lisbeth A. Ambrosius, Deborah W. Knapp
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundEarly detection and intervention research is expected to improve the outcomes for patients with high grade muscle invasive urothelial carcinoma (InvUC). With limited patients in suitable high-risk study cohorts, relevant animal model resear
Externí odkaz:
https://doaj.org/article/2e6bbabab2074828b5ba17889779a572
12-Lipoxygenase governs the innate immune pathogenesis of islet inflammation and autoimmune diabetes
Autor:
Abhishek Kulkarni, Annie R. Pineros, Melissa A. Walsh, Isabel Casimiro, Sara Ibrahim, Marimar Hernandez-Perez, Kara S. Orr, Lindsey Glenn, Jerry L. Nadler, Margaret A. Morris, Sarah A. Tersey, Raghavendra G. Mirmira, Ryan M. Anderson
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
Macrophages and related myeloid cells are innate immune cells that participate in the early islet inflammation of type 1 diabetes (T1D). The enzyme 12-lipoxygenase (12-LOX) catalyzes the formation of proinflammatory eicosanoids, but its role and mech
Externí odkaz:
https://doaj.org/article/34a90733e3ad4b8893ca68306c5ee215
Publikováno v:
Metabolites, Vol 12, Iss 4, p 344 (2022)
The polyamines—putrescine, spermidine, and spermine—are polycationic, low molecular weight amines with cellular functions primarily related to mRNA translation and cell proliferation. Polyamines partly exert their effects via the hypusine pathway
Externí odkaz:
https://doaj.org/article/86833127adfc474998bbf36073842152
Autor:
Masayuki Hatanaka, Emily Anderson-Baucum, Alexander Lakhter, Tatsuyoshi Kono, Bernhard Maier, Sarah A. Tersey, Yukio Tanizawa, Carmella Evans-Molina, Raghavendra G. Mirmira, Emily K. Sims
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Under conditions of high fat diet (HFD) consumption, glucose dyshomeostasis develops when β-cells are unable to adapt to peripheral insulin demands. Few studies have interrogated the molecular mechanisms of β-cell dysfunction at the level
Externí odkaz:
https://doaj.org/article/55e51cc8fc5a42f3821a8cee071ffc18
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2151 (2021)
Type 2 diabetes (T2D) typically occurs in the setting of obesity and insulin resistance, where hyperglycemia is associated with decreased pancreatic β-cell mass and function. Loss of β-cell mass has variably been attributed to β-cell dedifferentia
Externí odkaz:
https://doaj.org/article/9c0c5ebbaf624e9a92da71402a6fe983
Autor:
Annie R. Piñeros, Hongyu Gao, Wenting Wu, Yunlong Liu, Sarah A. Tersey, Raghavendra G. Mirmira
Publikováno v:
Metabolites, Vol 10, Iss 12, p 513 (2020)
Obesity is closely associated with adipose tissue inflammation and insulin resistance. Dysglycemia and type 2 diabetes results when islet β cells fail to maintain appropriate insulin secretion in the face of insulin resistance. To clarify the early
Externí odkaz:
https://doaj.org/article/f2e1b6063a2a4a52a958a190d0f6d33f
Publikováno v:
Biomarkers in Diabetes ISBN: 9783031080135
Biomarkers in Diabetes ISBN: 9783030813031
Biomarkers in Diabetes ISBN: 9783030813031
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de41f14006c8c845628794e861d9ae8
https://doi.org/10.1007/978-3-031-08014-2_31
https://doi.org/10.1007/978-3-031-08014-2_31
Publikováno v:
Endocrinology. 164(1)
The pathogeneses of the 2 major forms of diabetes, type 1 and type 2, differ with respect to their major molecular insults (loss of immune tolerance and onset of tissue insulin resistance, respectively). However, evidence suggests that dysfunction an
Autor:
FEI HUANG, ABHISHEK KULKARNI, FAROOQ SYED, DAVID J. MALONEY, SARAH A. TERSEY, RAGHAVENDRA G. MIRMIRA
Publikováno v:
Diabetes. 71
Type 1 diabetes (T1D) has become viewed as an autoimmune disease initiated and propagated by stress responses in islet β cells. The integrated stress response (ISR) is activated upon inflammatory signaling and delimits protein production through the