Zobrazeno 1 - 10
of 23
pro vyhledávání: '"SARAH ADIO"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Slippery sequences in mRNA can cause the ribosome to change its reading frame. Using smFRET, Poulis et al. show how reversible fluctuations of peptidyl-tRNA slow down translocation, alter ribosome dynamics, and favor spontaneous ribosome frameshiftin
Externí odkaz:
https://doaj.org/article/b60720c83b2f427b869fe2030ded5ee8
Publikováno v:
Nucleic Acids Research.
The DEAH-box helicase Prp43 has essential functions in pre-mRNA splicing and ribosome biogenesis, remodeling structured RNAs. To initiate unwinding, Prp43 must first accommodate a single-stranded RNA segment into its RNA binding channel. This allows
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c71006fcd89db8b973f55ce81ca41ac
https://doi.org/10.1093/nar/gkad362
https://doi.org/10.1093/nar/gkad362
Autor:
Heena Sharma, Sarah Adio, Tamara Senyushkina, Riccardo Belardinelli, Frank Peske, Marina V. Rodnina
Publikováno v:
Cell Reports, Vol 16, Iss 8, Pp 2187-2196 (2016)
Ribosome dynamics play an important role in translation. The rotation of the ribosomal subunits relative to one another is essential for tRNA-mRNA translocation. An important unresolved question is whether subunit rotation limits the rate of transloc
Externí odkaz:
https://doaj.org/article/865d132ae61e4de78fdc87dc37a19dcc
Autor:
Sarah Adio, Heena Sharma, Tamara Senyushkina, Prajwal Karki, Cristina Maracci, Ingo Wohlgemuth, Wolf Holtkamp, Frank Peske, Marina V Rodnina
Publikováno v:
eLife, Vol 7 (2018)
Release factors RF1 and RF2 promote hydrolysis of peptidyl-tRNA during translation termination. The GTPase RF3 promotes recycling of RF1 and RF2. Using single molecule FRET and biochemical assays, we show that ribosome termination complexes that carr
Externí odkaz:
https://doaj.org/article/b5b4525df75141a792bec2900ba14734
Publikováno v:
Proceedings of the National Academy of Sciences. 119
The DEAH/RHA helicase Prp43 remodels protein–RNA complexes during pre-messenger RNA (mRNA) splicing and ribosome biogenesis. The helicase activity and ATP turnover are intrinsically low and become activated by G-patch (gp) factors in the specific c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1695415524f75eddee5cfddae9450d5
https://doi.org/10.1073/pnas.2203567119
https://doi.org/10.1073/pnas.2203567119
Autor:
Sung-Hui Yi, Valentyn Petrychenko, Jan Erik Schliep, Akanksha Goyal, Andreas Linden, Ashwin Chari, Henning Urlaub, Holger Stark, Marina V Rodnina, Sarah Adio, Niels Fischer
Publikováno v:
Nucleic Acids Research
Selection of the translation start codon is a key step during protein synthesis in human cells. We obtained cryo-EM structures of human 48S initiation complexes and characterized the intermediates of codon recognition by kinetic methods using eIF1A a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::179d1de5afa26171c8ffc75114075ecc
https://hdl.handle.net/21.11116/0000-000A-CA89-821.11116/0000-000A-CA8B-6
https://hdl.handle.net/21.11116/0000-000A-CA89-821.11116/0000-000A-CA8B-6
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4612 (2009)
The protein family of kinesins contains processive motor proteins that move stepwise along microtubules. This mechanism requires the precise coupling of the catalytic steps in the two heads, and their precise mechanical coordination. Here we show tha
Externí odkaz:
https://doaj.org/article/fb14fd9956254758b08d533c407ce2d4
Author response: Dynamics of ribosomes and release factors during translation termination in E. coli
Autor:
Prajwal Karki, Ingo Wohlgemuth, Frank Peske, Cristina Maracci, Marina V. Rodnina, Sarah Adio, Wolf Holtkamp, Tamara Senyushkina, Heena Sharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1ce00e4b20c720b06351ba5da5d3832
https://doi.org/10.7554/elife.34252.023
https://doi.org/10.7554/elife.34252.023
Autor:
Wolf Holtkamp, Marina V. Rodnina, Frank Peske, Cristina Maracci, Ingo Wohlgemuth, Sarah Adio, Tamara Senyushkina, Heena Sharma, Prajwal Karki
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Release factors RF1 and RF2 promote hydrolysis of peptidyl-tRNA during translation termination. The GTPase RF3 promotes recycling of RF1 and RF2. Using single molecule FRET and biochemical assays, we show that ribosome termination complexes that carr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0805162b5b84d6cbe76b5d0a8f90cbae
https://doi.org/10.1101/243485
https://doi.org/10.1101/243485
Autor:
Günther Woehlke, Sarah Adio
Publikováno v:
FEBS Journal. 276:3641-3655
Members of the Kinesin-3 family are microtubule motors involved in the transport of membranous cargo. NcKin3 from the fungus Neurospora crassa is dimeric but inactivates one of its motor heads to generate nonprocessive motility. To determine how one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64e764e9cb4671e51f8587c892be5faa
https://doi.org/10.1111/j.1742-4658.2009.07083.x
https://doi.org/10.1111/j.1742-4658.2009.07083.x