Zobrazeno 1 - 10
of 296
pro vyhledávání: '"SANT P. CHAWLA"'
Autor:
Richard T. Kenney, John K. Cini, Susan Dexter, Manuel DaFonseca, Justus Bingham, Isabelle Kuan, Sant P. Chawla, Thomas M. Polasek, Jason Lickliter, Philip J. Ryan
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe benefits of recombinant interleukin-12 (rIL-12) as a multifunctional cytokine and potential immunotherapy for cancer have been sought for decades based on its efficacy in multiple mouse models. Unexpected toxicity in the first phase 2 s
Externí odkaz:
https://doaj.org/article/9baead1eb8e549ccaed6f20a613f9c70
Publikováno v:
Frontiers in Molecular Medicine, Vol 4 (2024)
Externí odkaz:
https://doaj.org/article/15eef36e2fb147b4866f9929703d0101
Autor:
Steven Attia, Vanessa Bolejack, Kristen N. Ganjoo, Suzanne George, Mark Agulnik, Daniel Rushing, Elizabeth T. Loggers, Michael B. Livingston, Jennifer Wright, Sant P. Chawla, Scott H. Okuno, Denise K. Reinke, Richard F. Riedel, Lara E. Davis, Christopher W. Ryan, Robert G. Maki
Publikováno v:
Cancer Medicine, Vol 12, Iss 2, Pp 1532-1539 (2023)
Abstract Background Regorafenib is one of several FDA‐approved cancer therapies targeting multiple tyrosine kinases. However, there are few subtype‐specific data regarding kinase inhibitor activity in sarcomas. We report results of a single arm,
Externí odkaz:
https://doaj.org/article/124378635bd247fb9b2242a52cc12063
Autor:
Mrinal M. Gounder, Narasimhan P. Agaram, Sally E. Trabucco, Victoria Robinson, Richard A. Ferraro, Sherri Z. Millis, Anita Krishnan, Jessica Lee, Steven Attia, Wassim Abida, Alexander Drilon, Ping Chi, Sandra P. D’ Angelo, Mark A. Dickson, Mary Lou Keohan, Ciara M. Kelly, Mark Agulnik, Sant P. Chawla, Edwin Choy, Rashmi Chugh, Christian F. Meyer, Parvathi A. Myer, Jessica L. Moore, Ross A. Okimoto, Raphael E. Pollock, Vinod Ravi, Arun S. Singh, Neeta Somaiah, Andrew J. Wagner, John H. Healey, Garrett M. Frampton, Jeffrey M. Venstrom, Jeffrey S. Ross, Marc Ladanyi, Samuel Singer, Murray F. Brennan, Gary K. Schwartz, Alexander J. Lazar, David M. Thomas, Robert G. Maki, William D. Tap, Siraj M. Ali, Dexter X. Jin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Comprehensive molecular profiles are required to understand and treat sarcomas, which comprise more than 70 different subtypes. Here, the authors profile the genomic landscape of 7494 sarcomas across 44 histologies using targeted panel sequencing and
Externí odkaz:
https://doaj.org/article/ded28dd2538e4114ba7de3e78b153f38
Publikováno v:
Frontiers in Molecular Medicine, Vol 3 (2023)
Background: Metastatic breast cancer is associated with a poor prognosis and therefore, innovative therapies are urgently needed. Here, we report on the results of a Phase I-II study using DeltaRex-G for chemotherapy resistant metastatic carcinoma of
Externí odkaz:
https://doaj.org/article/a2b6907909464891b3ceb859bc6c5171
Autor:
Sant P. Chawla, Walter Andree Tellez, Hripsime Chomoyan, Chrysler Valencia, Amir Ahari, Nadezhda Omelchenko, Stefan Makrievski, Don A. Brigham, Victoria Chua-Alcala, Doris Quon, Ania Moradkhani, Erlinda M. Gordon
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundIntratumoral injection of talimogene laherparepvec evokes a cytotoxic immune response. Therefore, the combination of talimogene laherparepvec with trabectedin and nivolumab may have synergistic effects in advanced sarcomas.Patients and meth
Externí odkaz:
https://doaj.org/article/e33f8a62e71649f58f857ead4dd4e0f7
Autor:
Laurie Eliason, Laura Grant, Anya Francis, Anna Cardellino, Ken Culver, Sant P. Chawla, Rob Arbuckle, Shibani Pokras
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 6, Iss 1, Pp 1-13 (2022)
Abstract Background The outlook for patients with metastatic synovial sarcoma (mSS) is poor. Better understanding of patient experience in this setting, beyond clinical measures, may guide improvements in management. Validated patient-reported outcom
Externí odkaz:
https://doaj.org/article/20abc574546b443b88ca684a5d3fb252
Autor:
Sant P. Chawla, Steven Wong, Doris Quon, Ania Moradkhani, Victoria S. Chua, Don A. Brigham, Rebecca A Reed, William Swaney, Frederick L. Hall, Erlinda M. Gordon
Publikováno v:
Frontiers in Molecular Medicine, Vol 2 (2022)
Background: Innovative treatments are urgently needed for metastatic cancer. DeltaRex-G, a tumor-targeted retrovector encoding a dominant-negative/cytocidal cyclin G1 (CCNG1 gene) inhibitor construct—has been tested in over 280 cancer patients worl
Externí odkaz:
https://doaj.org/article/ec84daaadc184d128fc1926eced547a0
Autor:
Seth M. Pollack, Neeta Somaiah, Dejka M. Araujo, Mihaela Druta, Brian A. Van Tine, Melissa A. Burgess, Sant P. Chawla, Mahesh Seetharam, Scott H. Okuno, Chet Bohac, Michael Chen, Sergey Yurasov, Steven Attia
Publikováno v:
Cancer Medicine, Vol 9, Iss 13, Pp 4593-4602 (2020)
Abstract Background Outcomes data regarding advanced synovial sarcoma (SS) and myxoid/round cell liposarcoma (MRCL) are limited, consisting primarily of retrospective series and post hoc analyses of clinical trials. Methods In this multi‐center ret
Externí odkaz:
https://doaj.org/article/2292b5dd195549049e097c6c426bed12
Autor:
Takashi Higuchi, Kei Kawaguchi, Kentaro Miyake, Hiromichi Oshiro, Zhiying Zhang, Sahar Razmjooei, Sintawat Wangsiricharoen, Kentaro Igarashi, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Scott D. Nelson, Sarah M. Dry, Yunfeng Li, Sant P. Chawla, Frederick C. Eilber, Shree Ram Singh, Hiroyuki Tsuchiya, Robert M. Hoffman
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 111, Iss , Pp 835-840 (2019)
Undifferentiated/unclassified soft-tissue sarcomas (USTS) is recalcitrant neoplasms that is usually treated with doxorubicin (DOX)-containing regimens as first-line therapy. Nanoparticle albumin-bound paclitaxel (nab-PTX) is a nanotechnology-based dr
Externí odkaz:
https://doaj.org/article/9349c389daaa466ebd861566e18c2a63