Zobrazeno 1 - 10 of 23 pro vyhledávání: '"SAMUEL KORMAN"'
1
Akademický článek
Atypical Asparagine Deamidation of NW Motif Significantly Attenuates the Biological Activities of an Antibody Drug Conjugate
Autor: Mingyan Cao, G. Patrick Hussmann, Yeqing Tao, Ellen O’Connor, Conner Parthemore, Diana Zhang-Hulsey, Dengfeng Liu, Yang Jiao, Niluka de Mel, Meagan Prophet, Samuel Korman, Jaytee Sonawane, Christina Grigoriadou, Yue Huang, Scott Umlauf, Xiaoyu Chen
Publikováno v: Antibodies, Vol 12, Iss 4, p 68 (2023)
Asparagine deamidation is a post-translational modification (PTM) that converts asparagine residues into iso-aspartate and/or aspartate. Non-enzymatic asparagine deamidation is observed frequently during the manufacturing, processing, and/or storage
Externí odkaz: https://doaj.org/article/4a1c6cf978184bb1870f19d9d0c1a91e
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2
Akademický článek
Identification of a CE-SDS shoulder peak as disulfide-linked fragments from common CH2 cleavages in IgGs and IgG-like bispecific antibodies
Autor: Mingyan Cao, Yang Jiao, Conner Parthemore, Samuel Korman, Jiao Ma, Alan Hunter, Greg Kilby, Xiaoyu Chen
Publikováno v: mAbs, Vol 13, Iss 1 (2021)
Fragmentation is a well-characterized degradation pathway of therapeutic antibodies and is usually monitored by capillary electrophoresis–sodium dodecyl sulfate (CE-SDS). Although fragments due to cleavage in CH2 domains linked by intrachain disulf
Externí odkaz: https://doaj.org/article/856756af5dca4848857256f0e2f60f64
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3
Characterization and Monitoring of a Novel Light-heavy-light Chain Mispair in a Therapeutic Bispecific Antibody
Autor: Greg Kilby, Xiaoyu Chen, Matthew Aspelund, Conner Parthemore, Alan K. Hunter, Yang Jiao, Mingyan Cao, Samuel Korman
Publikováno v: Journal of pharmaceutical sciences. 110(8)
Site-specific cysteine engineering, along with other genetic mutations, is broadly implemented in bispecific antibodies (bsAb). Thus far, homodimer, half hole antibody, one-light chain mispaired and light chain swapped variants have been reported as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bde2697f1c4b42790f70f0bbcfece77
https://pubmed.ncbi.nlm.nih.gov/33894207
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4
Identification of a CE-SDS shoulder peak as disulfide-linked fragments from common CH2 cleavages in IgGs and IgG-like bispecific antibodies
Autor: Greg Kilby, Yang Jiao, Xiaoyu Chen, Mingyan Cao, Conner Parthemore, Alan K. Hunter, Jiao Ma, Samuel Korman
Publikováno v: mAbs
article-version (VoR) Version of Record
Fragmentation is a well-characterized degradation pathway of therapeutic antibodies and is usually monitored by capillary electrophoresis–sodium dodecyl sulfate (CE-SDS). Although fragments due to cleavage in CH2 domains linked by intrachain disulf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a890c5b5911bba601a32035fe87b62
https://doi.org/10.1080/19420862.2021.1981806
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10
DETERMINATION OF RADIOACTIVELY LABELED GLOBULIN TURNOVER BY THE DIRECT WHOLE-BODY COUNTING TECHNIQUE*
Autor: Samuel Korman, Samuel Fine, Helen Hamel, Stanton H. Cohn, Stuart W. Lippincott
Publikováno v: Journal of Clinical Investigation. 40:697-702
The turnover rates of I131 labeled beta and gamma globulins in a hypergammaglobulinemic multiple myeloma patient were compared by the conventional serum and urinary excretion methods with those found using the in vivo whole-body gamma spectrometer co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e1f5a1e5f63b85bff89926eb081801
https://doi.org/10.1172/jci104302
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