Zobrazeno 1 - 10
of 1 386
pro vyhledávání: '"SAMP8"'
Autor:
Lori R. Bernstein, Amelia C. L. Mackenzie, Charles L. Chaffin, Se-Jin Lee, Duane C. Kraemer, Istvan Merchenthaler
Publikováno v:
Reproductive Biology and Endocrinology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Elevated FSH often occurs in women of advanced maternal age (AMA, age ≥ 35) and in infertility patients undergoing controlled ovarian stimulation (COS). There is controversy on whether high endogenous FSH contributes to infertil
Externí odkaz:
https://doaj.org/article/7db6bcaa8c2f493cab90c5b1c30b9ec8
Publikováno v:
Experimental Gerontology, Vol 192, Iss , Pp 112443- (2024)
Objective: Ferroptosis has been recognized as being closely associated with cognitive impairment. Research has established that Alzheimer's disease (AD)-associated proteins, such as amyloid precursor protein (APP) and phosphorylated tau, are involved
Externí odkaz:
https://doaj.org/article/be89fd73a6944cf99d9e2d30f3033c10
Autor:
Aina Bellver-Sanchis, Pedro A Ávila-López, Iva Tic, David Valle-García, Marta Ribalta-Vilella, Luis Labrador, Deb Ranjan Banerjee, Ana Guerrero, Gemma Casadesus, Coralie Poulard, Mercè Pallàs, Christian Griñán-Ferré
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 11, Pp 2532-2542 (2024)
Dysregulation of G9a, a histone-lysine N-methyltransferase, has been observed in Alzheimer’s disease and has been correlated with increased levels of chronic inflammation and oxidative stress. Likewise, microRNAs are involved in many biological pro
Externí odkaz:
https://doaj.org/article/4c3e64e7fae94dd28b961cd5185e547a
Autor:
Dalong Zhang, Zehao Wang, Shuangshuang Guo, Yue Sun, Dezheng Zhou, Wen Li, Jing Yan, Yongjie Chen, Suhui Luo, Guowei Huang, Zhiyong Qian, Zhenshu Li
Publikováno v:
Experimental Gerontology, Vol 196, Iss , Pp 112577- (2024)
Total cholesterol (TC) and the cholesterol oxidation product 27-hydroxycholesterol (27-OHC) are both increased in the elderly. Accumulating evidence has linked 27-OHC to glucose metabolism in the brain, while docosahexaenoic acid (DHA) has been shown
Externí odkaz:
https://doaj.org/article/59b52b47a3884094a2fced8fb8782349
Akademický článek
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Autor:
Shixiong Zhang, Mengnan Li, Liping Chang, Xinjing Mao, Yuning Jiang, Xiaogang Shen, Kunxu Niu, Xuan Lu, Runtao Zhang, Yahui Song, Kun Ma, Hongrong Li, Cong Wei, Yunlong Hou, Yiling Wu
Publikováno v:
Frontiers in Microbiology, Vol 14 (2024)
PurposeThe senescence-accelerated prone mouse 8 (SAMP8) is a widely used model for accelerating aging, especially in central aging. Mounting evidence indicates that the microbiota-gut-brain axis may be involved in the pathogenesis and progression of
Externí odkaz:
https://doaj.org/article/c19da3949d63421f9ea35b9d7feff068
Autor:
Rui Fan, Ying Zhang, Rui Liu, Chan Wei, Xiujuan Wang, Xin Wu, Xiaochen Yu, Zhen Li, Ruixue Mao, Jiani Hu, Na Zhu, Xinran Liu, Yong Li, Meihong Xu
Publikováno v:
Nutrients, Vol 16, Iss 12, p 1907 (2024)
The skin, serving as the body’s primary defense against external elements, plays a crucial role in protecting the body from infections and injuries, as well as maintaining overall homeostasis. Skin aging, a common manifestation of the aging process
Externí odkaz:
https://doaj.org/article/249e4ccab20b4b5a8e13066601bc9453
Autor:
Hae Lim Kim, Sung Kwon Lee, Da Eun Min, Tonking Bastola, Bo Yoon Chang, Jin Hye Bae, Dong Ryung Lee
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 2, Pp 1287-1305 (2023)
Alzheimer’s disease (AD) is a worldwide problem. Currently, there are no effective drugs for AD treatment. Scrophularia buergeriana Miquel (SB) is a traditional herbal medicine used in Korea to treat various diseases. Our previous studies have show
Externí odkaz:
https://doaj.org/article/18224ce72a5a4b88ae85681f8e384292
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 720 (2024)
Hydroxyhydroquinone (HHQ) is an oxidative component produced by roasting coffee beans and has been reported to generate relatively large amounts of reactive oxygen species (ROS). In this study, we used senescence-accelerated mouse prone 8 (SAMP8) mic
Externí odkaz:
https://doaj.org/article/31147244fab14baf8d6777787b42f74b
Publikováno v:
Experimental Gerontology, Vol 177, Iss , Pp 112198- (2023)
Senescence-accelerated mouse prone 8 (SAMP8) mice exhibit cognitive defects and neuron loss with aging, and were used to study anti-aging effects of Dendrobium nobile alkaloids (DNLA). DNLA (20 and 40 mg/kg) were orally administered to SAMP8 mice fro
Externí odkaz:
https://doaj.org/article/74e12fa8301d4a628f7c415e9272709c