Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration

Autor: Vighi, Eleonora, Trifunović, Dragana, Veiga-Crespo, Patricia, Rentsch, Andreas, Hoffmann, Dorit, Sahaboglu, Ayse, Strasser, Torsten, Kulkarni, Manoj, Bertolotti, Evelina, van den Heuvel, Angelique, Peters, Tobias, Reijerkerk, Arie, Euler, Thomas, Ueffing, Marius, Schwede, Frank, Genieser, Hans-Gottfried, Gaillard, Pieter, Marigo, Valeria, Ekström, Per, Paquet-Durand, François

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2018 Mar . 115(13), E2997-E3006.

Externí odkaz: https://www.jstor.org/stable/26508269

Age-related Macular Degeneration and Current Therapies

Autor: AKKAYA, Pakize Nur, HOSSEINZADEH, Zohreh, ELMAS, Çiğdem, SAHABOGLU, Ayse

Publikováno v: Volume: 4, Issue: 3 125-135
Journal of Gazi University Health Sciences Institute
Gazi Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

Age-related macular degeneration (AMD) is degenerative retinal eye disease that affects central vision. It is estimated that by 2040, approximately 288 million people in the world might be affected by AMD. Considering the rapidly aging world populati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=tubitakulakb::ad1ca274e3c332f19bb28eee09ce0a22
https://dergipark.org.tr/tr/pub/guhes/issue/74762/1176081

Temporal progression of PARP activity in the Prph2 mutant rd2 mouse: Neuroprotective effects of the PARP inhibitor PJ34.

Autor: Sahaboglu, Ayse¹ ayse.sahaboglu-tekgoez@klinikum.uni-tuebingen.de, Sharif, Alaa^1,2, Feng, Lili¹, Secer, Enver³, Zrenner, Eberhart^1,4, Paquet-Durand, François¹ francois.paquet-durand@klinikum.uni-tuebingen.de

Publikováno v: PLoS ONE. 7/19/2017, Vol. 12 Issue 7, p1-12. 12p.

PARP inhibitors : the protective ways on retinal degeneration

Autor: Sahaboglu, Ayse., Miranda Sanz, María., Durdagi, Serdar., Kayik, Gulru., Zrenner, Eberhart.

Publikováno v: CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)

Este artículo se encuentra disponible en la siguiente URL: https://iovs.arvojournals.org/article.aspx?articleid=2744548 Esta comunicación se presentó en el ARVO Annual Meeting Abstract celebrado en Vancouver, Canadá entre el 28 de abril y el 2 de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::916eb75c36a8be99d595abd532d9ea03
http://hdl.handle.net/10637/11657

Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration

Autor: Sahaboglu, Ayse, Barth, Melanie, Secer, Enver, del Amo, Eva M., Urtti, Arto, Arsenijevic, Yvan, Zrenner, Eberhart, Paquet-Durand, Francois

Publikováno v: Sahaboglu, A, Barth, M, Secer, E, Del Amo, E M, Urtti, A, Arsenijevic, Y, Zrenner, E & Paquet-Durand, F 2016, ' Olaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration ', Scientific Reports, vol. 6 . https://doi.org/10.1038/srep39537
Scientific reports, vol. 6, pp. 39537
Scientific Reports

The enzyme poly-ADP-ribose-polymerase (PARP) mediates DNA-repair and rearrangements of the nuclear chromatin. Generally, PARP activity is thought to promote cell survival and in recent years a number of PARP inhibitors have been clinically developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::fbb6b5563b141b5336c0ecd940b9accc