1396-P: Critical Cellular Functions That Mediate the Early Stages of Adipogenesis Are Directly Influenced by 14-3-3zeta and Its Interactome

Autor: SABRI A. RIAL, AMAL ALKHOURY, GENEVIEVE LAVOIE, PHILIPPE ROUX, THOMAS M. DURCAN, AIDA MARTINEZ-SANCHEZ, GARETH E. LIM

Publikováno v: Diabetes. 71

Aim: We previously discovered that 14-3-3-zeta (14-3-3ζ) was essential for adipocyte differentiation. Although 14-3-3ζ scaffold is not a transcription factor (TF) , it undergoes nuclear translocation during adipogenesis. Considering its diverse int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be37ed6b352704ff838da3ed5d8c76be
https://doi.org/10.2337/db22-1396-p

Hepatic BSCL2 (Seipin) Deficiency Disrupts Lipid Droplet Homeostasis and Increases Lipid Metabolism via SCD1 Activity

Autor: Sabri Ahmed Rial, Mohamed Amine Lounis, Jessica C. Ralston, Catherine Mounier, Simon Lalonde, David M. Mutch, Karl-F. Bergeron

Publikováno v: Lipids. 52:129-150

Berardinelli-Seip congenital lipodystrophy (BSCL) is an autosomal recessive disorder. The more severe form, designated BSCL2, arises due to mutations in the BSCL2 gene. Patients with BSCL2, as well as Bscl2 −/− mice, have a near total absence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe6a00f733dfb9a1be2ca362c2aad70
https://doi.org/10.1007/s11745-016-4210-5

Hexanoic, Octanoic and Decanoic Acids Promote Basal and Insulin-Induced Phosphorylation of the Akt-mTOR Axis and a Balanced Lipid Metabolism in the HepG2 Hepatoma Cell Line

Autor: Gaetan Ravaut, Sabri Ahmed Rial, Catherine Mounier, Karl-F. Bergeron, Tommy B Malaret

Publikováno v: Molecules
Volume 23
Issue 9
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 23, Iss 9, p 2315 (2018)

Metabolic illnesses such as non-alcoholic fatty liver disease (NAFLD) are in constant increase worldwide. Highly consumed long chain fatty acids (LCFA) are among the most obesogenic and steatogenic nutrients. Hepatic steatosis is associated with seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbbfa1395614e966cd3155e5cda4d77

Stearoyl CoA desaturase 1 (SCD1) and Seipin: Important players in hepatic steatosis?

Autor: Jocelyne Magré, Sabri Ahmed Rial, Phillipe Costet, Simon Lalonde, Lounis Amine, Xavier Prieur, Catherine Mounier

Publikováno v: The FASEB Journal. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5403998999c5b3d991b575e6e1b46b00
https://doi.org/10.1096/fasebj.27.1_supplement.813.1