Zobrazeno 1 - 10
of 91
pro vyhledávání: '"SABINE M. KLAUCK"'
Autor:
Roxana Damiescu, Rümeysa Yücer, Sabine M. Klauck, Gerhard Bringmann, Thomas Efferth, Mona Dawood
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3087 (2024)
Naphthylisoquinoline (NIQ) alkaloids are rising as a promising class of secondary metabolites with pharmaceutical potential. NF-κB has already been recognized as a significant modulator of cancer proliferation and drug resistance. We have previously
Externí odkaz:
https://doaj.org/article/3f9506c491ec43df97a55ce4e709c39c
Publikováno v:
Molecules, Vol 28, Iss 15, p 5658 (2023)
The c-MYC oncogene regulates multiple cellular activities and is a potent driver of many highly aggressive human cancers, such as leukemia and triple-negative breast cancer. The oxadiazole class of compounds has gained increasing interest for its ant
Externí odkaz:
https://doaj.org/article/03d6c39c01394436bb4489264b473131
Autor:
Mohamed Elbadawi, Joelle C. Boulos, Mona Dawood, Min Zhou, Waseem Gul, Mahmoud A. ElSohly, Sabine M. Klauck, Thomas Efferth
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1107 (2023)
The proto-oncogenic transcription factor c-MYC plays a pivotal role in the development of tumorigenesis, cellular proliferation, and the control of cell death. Its expression is frequently altered in many cancer types, including hematological maligna
Externí odkaz:
https://doaj.org/article/23a580f186cd44e38c6dd828fe7df242
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1121 (2022)
Corticotropin-releasing factor (CRF) mediates stress responses and alters the gut-brain axis, contributing to the pathogenesis of irritable bowel syndrome (IBS), which is recognized by abdominal pain accompanied by bowel habit disturbance. STW 5-II,
Externí odkaz:
https://doaj.org/article/99b6879ba61c42de98dd5d21a6876f17
Autor:
Joelle C. Boulos, Mohamed E. M. Saeed, Manik Chatterjee, Yagmur Bülbül, Francesco Crudo, Doris Marko, Markus Munder, Sabine M. Klauck, Thomas Efferth
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1126 (2021)
Crizotinib was a first generation of ALK tyrosine kinase inhibitor approved for the treatment of ALK-positive non-small-cell lung carcinoma (NSCLC) patients. COMPARE and cluster analyses of transcriptomic data of the NCI cell line panel indicated tha
Externí odkaz:
https://doaj.org/article/0287c6085c9e4590b630f9d66419fce4
Publikováno v:
Diagnostics, Vol 8, Iss 3, p 62 (2018)
In the past decade, multi-national and multi-center efforts were launched to sequence prostate cancer genomes, transcriptomes, and epigenomes with the aim of discovering the molecular underpinnings of tumorigenesis, cancer progression, and therapy re
Externí odkaz:
https://doaj.org/article/2b914c9a489d4a3bb946c89e991a21ac
Autor:
Thomas Efferth, Jan-Heiner Küpper, Caroline Knorz, Sabine M. Klauck, Sara Abdelfatah, Janine Naß
Publikováno v:
Cell Biology and Toxicology. 38:325-345
Pyrrolizidine alkaloids (PAs) are a large group of highly toxic chemical compounds, which are found as cross-contaminants in numerous food products (e.g., honey), dietary supplements, herbal teas, and pharmaceutical herbal medicines. PA contamination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b002d7645f86af06ad0168549204f775
https://doi.org/10.1007/s10565-021-09599-9
https://doi.org/10.1007/s10565-021-09599-9
Autor:
Glen Kristiansen, Stephan Hauser, Manuel Ritter, Jörg Ellinger, Holger Sültmann, Laura Hüser, Yuri Tolkach, Romina Zarbl, Dimo Dietrich, Peter Altevogt, Sabine M. Klauck, Simone Bauer
Publikováno v:
The American Journal of Pathology. 191:618-630
CD24 is overexpressed in many human cancers and is a driver of tumor progression. Herein, molecular mechanisms leading to up-regulation of CD24 in prostate cancer were studied. DNA methylation of the CD24 gene promoter at four loci using quantitative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68976e63f421d394a6dbe0bb38c0142
https://doi.org/10.1016/j.ajpath.2020.12.014
https://doi.org/10.1016/j.ajpath.2020.12.014
Autor:
MOHAMED E. M. SAEED, JOELLE C. BOULOS, SABRINA B. MÜCKLICH, ELLEN LEICH, MANIK CHATTERJEE, SABINE M. KLAUCK, THOMAS EFFERTH
Publikováno v:
Cancer Genomics Proteomics
Background/Aim: Multiple myeloma (MM) is characterized by accumulation of a malignant clone of plasma cells in the bone marrow. Curative treatments are not yet available. Therefore, we undertook a drug repurposing approach to identify possible candid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbb3d11d80c6a2a2c24edf4463a1a6f
https://pubmed.ncbi.nlm.nih.gov/35985681
https://pubmed.ncbi.nlm.nih.gov/35985681
Autor:
Xiaohua Lu, Sebastian Blatt, Mona Dawood, Sabine M. Klauck, Edmond Fleischer, Peer W. Kämmerer, Thomas Efferth
Publikováno v:
European Journal of Pharmacology. 930:175158
The vascular endothelial growth factor receptor 2 (VEGFR2) is widely recognized as a key effector in angiogenesis and cancer progression and has been considered a critical target for the development of anti-cancer drugs. Artemisinin (ARS) and its der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b198915b412649df0c0f6f313e365e49
https://doi.org/10.1016/j.ejphar.2022.175158
https://doi.org/10.1016/j.ejphar.2022.175158