Zobrazeno 1 - 10
of 14
pro vyhledávání: '"S6K, S6 kinase"'
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 491-506 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Wnt/β-catenin and phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin complex 1 (PI3K/AKT/mTORC1) pathways both are critically involved in colorectal cancer (CRC) development, although they are implicated in the modulation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7a306ac692719a8347e0c547725351
http://www.sciencedirect.com/science/article/pii/S2352345X20300515
http://www.sciencedirect.com/science/article/pii/S2352345X20300515
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 99-115 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 99-115 (2021)
Background & Aims Chronic amino acid (AA) deficiency, as in kwashiorkor, reduces the size of the pancreas through an effect on mammalian target of rapamycin complex 1 (mTORC1). Because of the physiological importance of AAs and their role as a substr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bdfa7077fd78998f54db32a754523b3
https://pubmed.ncbi.nlm.nih.gov/32735995
https://pubmed.ncbi.nlm.nih.gov/32735995
Publikováno v:
The Journal of Biological Chemistry
Small GTPases cycle between an inactive GDP-bound and an active GTP-bound state to control various cellular events, such as cell proliferation, cytoskeleton organization, and membrane trafficking. Clarifying the guanine nucleotide-bound states of sma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f125658ccb26ca5c615e65a05a3c4c7
https://doi.org/10.1016/j.jbc.2021.101428
https://doi.org/10.1016/j.jbc.2021.101428
Autor:
Justyna Bajdzienko, Andreas Kern, Mila Basic, Alexandra Hertel, Mariana Tellechea, Alexandra Stolz, Florian Bonn, Christian Behl, Anja Bremm
Publikováno v:
The Journal of Biological Chemistry
Autophagy is a major cellular quality control system responsible for the degradation of proteins and organelles in response to stress and damage to maintain homeostasis. Ubiquitination of autophagy-related proteins or regulatory components is importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6aec8482a221b2fc2ecdbdb5981944
https://doi.org/10.1016/j.jbc.2021.101263
https://doi.org/10.1016/j.jbc.2021.101263
Autor:
Jae-Hoon Bae, Dae Kyu Song, Seung-Jae Kim, Jae Ho Lee, Seung Soon Im, Mi-Young Kim, Yong-Ho Ahn, Goo Taeg Oh, Yong Deuk Kim, Hye Suk Kang, Young Kyo Seo
Publikováno v:
Biochemical Journal
Insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2), one of the most abundant circulating IGFBPs, is known to attenuate the biological action of IGF-1. Although the effect of IGFBP-2 in preventing metabolic disorders is well known, its regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1394e988fcc438efe73181da17346cbf
https://doi.org/10.1042/bj20141248
https://doi.org/10.1042/bj20141248
Autor:
Jessica Guenzle, Sven A. Lang, Hans J. Schlitt, Peter Bronsert, Christine Wagner, Katharina Schmidt, Claus Hellerbrand, Peter Dietrich, Christina Hackl, Edward K. Geissler, Stefan Fichtner-Feigl
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 12, Pp 1198-1208 (2018)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Mammalian target of rapamycin complex 2 (mTORC2) with its pivotal component rapamycin-insensitive companion of mTOR (RICTOR) is the major regulator of AKT phosphorylation and is increasingly implicated in tumor growth and progression. In cutaneous me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29f172098b8464f3ec60037df097799
https://www.ncbi.nlm.nih.gov/pubmed/30404068
https://www.ncbi.nlm.nih.gov/pubmed/30404068
Autor:
Bola Aladegbami, Brad W. Warner, Jun Guo, Lauren Barron, Raphael C. Sun, Christopher R. Erwin
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 2, Pp 231-244 (2017)
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 2, Pp 231-244 (2017)
Background & Aims Intestinal adaptation is a compensatory response to the massive loss of small intestine after surgical resection. We investigated the role of intestinal epithelial cell–specific mammalian target of rapamycin complex 1 (i-mTORC1) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b365fa487e99bcd92c2c5259436ade5
https://pubmed.ncbi.nlm.nih.gov/28275690
https://pubmed.ncbi.nlm.nih.gov/28275690
Akademický článek
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Autor:
Khalid Sossey-Alaoui, William P. Schiemann, Gangarao Davuluri, David Danielpour, Jenny G. Parvani, Michael K. Wendt, Christine Espinosa, Maozhen Tian
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 3, Pp 317-328 (2015)
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 3, Pp 317-328 (2015)
Transforming growth factor–β (TGF-β) functions to suppress tumorigenesis in normal mammary tissues and early-stage breast cancers and, paradoxically, acts to promote the metastasis and chemoresistance in late-stage breast cancers, particularly tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510a4d84d1c2128f9dd6612f8089b539
https://pubmed.ncbi.nlm.nih.gov/25810016
https://pubmed.ncbi.nlm.nih.gov/25810016
Autor:
Jiwen Wang, Fang Ding, Xinxin Li, Haohan Wang, Wenqiang Sun, Lingli Sun, Chunchun Han, Hehe Liu
Publikováno v:
Bioscience Reports
Bioscience Reports, Vol 34, Iss 5, p e00143 (2014)
Bioscience Reports, Vol 34, Iss 5, p e00143 (2014)
FST (follistatin) is essential for skeletal muscle development, but the intracellular signalling networks that regulate FST-induced effects are not well defined. We sought to investigate whether FST promotes the proliferation of myoblasts through the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2320703b310afb5521353123b95740e3
https://pubmed.ncbi.nlm.nih.gov/25200144
https://pubmed.ncbi.nlm.nih.gov/25200144