Zobrazeno 1 - 10
of 135
pro vyhledávání: '"S1p1 receptor"'
Autor:
Jonatan Martínez-Gardeazabal, Gorka Pereira-Castelo, Marta Moreno-Rodríguez, Alberto Llorente-Ovejero, Manuel Fernández, Iván Fernández-Vega, Iván Manuel, Rafael Rodríguez-Puertas
Publikováno v:
Neurobiology of Disease, Vol 202, Iss , Pp 106713- (2024)
Some specific lipid molecules in the brain act as signaling molecules, neurotransmitters, or neuromodulators, by binding to specific G protein-coupled receptors (GPCR) for neurolipids. One such receptor, sphingosine 1-phosphate receptor subtype 1 (S1
Externí odkaz:
https://doaj.org/article/5362973c6a1d4235a640d383951a698b
Akademický článek
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Autor:
Sun Jun Park, Jushin Kim, Jaehwan Kim, Yoowon Kim, Elijah Hwejin Lee, Hyeon Jeong Kim, Siwon Kim, Byungeun Kim, Rium Kim, Ji Won Choi, Jong-Hyun Park, Ki Duk Park
Publikováno v:
Molecules, Vol 27, Iss 9, p 2818 (2022)
Sphingosine-1-phosphate-1 (S1P1) receptor agonists are well-known drugs for treating multiple sclerosis (MS) caused by autoreactive lymphocytes that attack the myelin sheath. Therefore, an effective therapeutic strategy is to reduce the lymphocytes i
Externí odkaz:
https://doaj.org/article/9513982af7384ce397007a0804d18113
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Bisera Stepanovska Tanturovska, Aleksandra Zivkovic, Faik Imeri, Thomas Homann, Burkhard Kleuser, Holger Stark, Andrea Huwiler
Publikováno v:
Molecules, Vol 26, Iss 17, p 5134 (2021)
Sphingosine 1-phosphate (S1P) is an extensively studied signaling molecule that contributes to cell proliferation, survival, migration and other functions through binding to specific S1P receptors. The cycle of S1P1 internalization upon S1P binding a
Externí odkaz:
https://doaj.org/article/17a2c0a5ef064ea1b03c5ffcb1344f1f
Publikováno v:
Drug Design, Development and Therapy, Vol Volume11, Pp 123-131 (2016)
Stipo Jurcevic,1 Pierre-Eric Juif,2 Colleen Hamid,3 Roseanna Greenlaw,3 Daniele D’Ambrosio,2 Jasper Dingemanse2 1Department of Biomedical Sciences, University of Westminster, London, UK; 2Department of Clinical Pharmacology, Actelion Pharmaceutical
Externí odkaz:
https://doaj.org/article/759723fb252c43389cb1f1e855f26e74
Publikováno v:
Drugs of today (Barcelona, Spain : 1998). 58(7)
Treating moderate to severe ulcerative colitis (UC) has been enriched by the increasing number of drugs available for this disease. However, failure of conventional therapies, an incomplete response, or loss of response to biologics is experienced in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c31169cfb999cde7f15598f1955141c
https://pubmed.ncbi.nlm.nih.gov/35851870
https://pubmed.ncbi.nlm.nih.gov/35851870
Publikováno v:
Br J Clin Pharmacol
Aims Assessment of time to attain steady state as well as drug accumulation following long-term treatment with the selective sphingosine-1-phosphate 1 receptor modulator cenerimod and prediction of the incidence of low total lymphocyte (LY) counts. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2027354569f73144bb4238429cb2f937
https://doi.org/10.1111/bcp.14182
https://doi.org/10.1111/bcp.14182
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1191, p 1191 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1191
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1191
Cenerimod is a potent, selective sphingosine 1-phosphate receptor 1 (S1P1) modulator currently investigated in a Phase IIb study in patients with systemic lupus erythematosus (SLE) (NCT03742037). S1P1 receptor modulators sequester circulating lymphoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e225f551d22cb676b697aa67152686b6
https://www.mdpi.com/1422-0067/23/3/1191
https://www.mdpi.com/1422-0067/23/3/1191
Autor:
Thomas Homann, Aleksandra Zivkovic, Andrea Huwiler, Bisera Stepanovska Tanturovska, Faik Imeri, Holger Stark, Burkhard Kleuser
Publikováno v:
Molecules
Volume 26
Issue 17
Stepanovska Tanturovska, Bisera; Zivkovic, Aleksandra; Imeri, Faik; Homann, Thomas; Kleuser, Burkhard; Stark, Holger; Huwiler, Andrea (2021). ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo. Molecules, 26(17) Molecular Diversity Preservation International MDPI 10.3390/molecules26175134
Molecules, Vol 26, Iss 5134, p 5134 (2021)
Volume 26
Issue 17
Stepanovska Tanturovska, Bisera; Zivkovic, Aleksandra; Imeri, Faik; Homann, Thomas; Kleuser, Burkhard; Stark, Holger; Huwiler, Andrea (2021). ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo. Molecules, 26(17) Molecular Diversity Preservation International MDPI 10.3390/molecules26175134
Molecules, Vol 26, Iss 5134, p 5134 (2021)
Sphingosine 1-phosphate (S1P) is an extensively studied signaling molecule that contributes to cell proliferation, survival, migration and other functions through binding to specific S1P receptors. The cycle of S1P1 internalization upon S1P binding a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5eb3ae48ce46de4aa0f2be9b0736ad