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Autor:
Johannes G. Kusters, Hubert G. M. Niesters, R.A. de Man, R G van der Molen, H.L.A. Janssen, Rekha S. Binda, Dave Sprengers, S.W. Schalm
Publikováno v:
Journal of Viral Hepatitis, 14(10), 743-749. Wiley-Blackwell Publishing Ltd
Journal of viral hepatitis, 14(10), 743-749. Wiley-Blackwell
Journal of viral hepatitis, 14(10), 743-9. Wiley
Journal of viral hepatitis, 14(10), 743-749. Wiley-Blackwell
Journal of viral hepatitis, 14(10), 743-9. Wiley
Only in a minority of patients with chronic hepatitis B (CHB) will treatment with interferon (IFN)-alpha or nucleoside analogues lead to sustained virological response. In vivo immunization (IVI) following virus suppression aims to optimize condition
Publikováno v:
Alimentary Pharmacology & Therapeutics. 6:459-468
SUMMARY The pharmacokinetics of cyclosporin after oral administration were studied in seven patients with non-end stage primary biliary cirrhosis (PBC) without previous cyclosporin treatment (Group I), a control group of nine patients with skin disea
Autor:
Amar P. Dhillon, Johan Westin, Elke Verheij-Hart, Avidan U. Neumann, Martin Lagging, Kristoffer Hellstrand, Gabriele Missale, Stefan Zeuzem, Jean-Michel Pawlotsky, S.W. Schalm, A. I. Romero, Gunnar Norkrans, Francesco Negro
Publikováno v:
Journal of Viral Hepatitis. 14:29-35
Liver steatosis is highly prevalent in chronic hepatitis C virus (HCV) infection, especially in patients infected with genotype 3 virus, but its significance for the outcome of antiviral treatment is not fully understood. We have monitored steatosis
Autor:
R.J. de Knegt, S.W. Schalm, M. J. C. Eijkemans, Bettina E. Hansen, Bart J. Veldt, J. D. F. Habbema, Theo Stijnen
Publikováno v:
Publons
Alimentary Pharmacology & Therapeutics, 21(5), 539-547. Wiley-Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics, 21(5), 539-547. Wiley-Blackwell Publishing Ltd
Summary Background : Current guidelines for stopping treatment of chronic hepatitis C are based on hepatitis C ribonucleic acid measurements at 12 and 24 weeks. Aim : To explore an alternative approach for making individualized recommendations about
Autor:
S.W. Schalm, R.A. de Man, H.L.A. Janssen, Hajo J. Flink, B.E. Hansen, M. van Zonneveld, Dave Sprengers
Publikováno v:
Gut, 54(11), 1604-1609. BMJ Publishing Group
Background and aims: Flares are a well known phenomenon during antiviral treatment for chronic hepatitis B. Little is known about the effect of flares on response. We investigated the timing and characteristics of flares, in relation to treatment res
Autor:
J.M. Vrolijk, Bart L. Haagmans, Ralf Bartenschlager, S.W. Schalm, Artur Kaul, Volker Lohmann, Bettina E. Hansen
Publikováno v:
Journal of Virological Methods, 110, 201-209. Elsevier
Overall treatment results of chronic hepatitis C have improved markedly with the introduction of pegylated interferon-alpha (PEG-IFN-alpha) and ribavirin combination therapy. However, cure rates in the most common genotype 1 infection are still unsat
Autor:
Pieter E. Zondervan, H.L.A. Janssen, Jaap Kwekkeboom, S.W. Schalm, Thjon J. Tang, Hubert G. M. Niesters, R.A. de Man, Jon D. Laman
Publikováno v:
Journal of Viral Hepatitis, 10, 159-167. Wiley-Blackwell Publishing Ltd
Journal of viral hepatitis, 10(3), 159-67. Wiley
Journal of viral hepatitis, 10(3), 159-67. Wiley
Cytotoxic T lymphocytes (CTL) and Kupffer cells play an important role in the immune control of hepatitis B virus (HBV), but may also induce liver injury during infection. We investigated the intrahepatic immune response in liver biopsies of chronic
Publikováno v:
Transplant International. 15:61-72
Autor:
P Griffioen, H. J. F. Van Hoogstraten, J. van Hattum, W. Van Steenbergen, G. P. van Berge Henegouwen, G. J. Boland, H.R. van Buuren, Wim C. J. Hop, S.W. Schalm, Frank P. Vleggaar
Publikováno v:
American Journal of Gastroenterology, 95(8), 2015-2022. Springer Nature
OBJECTIVE PSC has characteristics of an (auto)immune-mediated disease: however, few studies have evaluated corticosteroid therapy for this disorder. METHODS We performed an 8-wk double-blind randomized pilot study to assess the effects of additional