Zobrazeno 1 - 10
of 61
pro vyhledávání: '"S.R Murthy Madiraju"'
Autor:
Elite Possik, Laura-Lee Klein, Perla Sanjab, Ruyuan Zhu, Laurence Côté, Ying Bai, Dongwei Zhang, Howard Sun, Anfal Al-Mass, Abel Oppong, Rasheed Ahmad, Alex Parker, S.R. Murthy Madiraju, Fahd Al-Mulla, Marc Prentki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt that hydrol
Externí odkaz:
https://doaj.org/article/79bea110421e4fefa73fb7ee3e0d54e0
Autor:
Anfal Al-Mass, Pegah Poursharifi, Marie-Line Peyot, Roxane Lussier, Isabelle Chenier, Yat Hei Leung, Anindya Ghosh, Abel Oppong, Elite Possik, Yves Mugabo, Rasheed Ahmad, Robert Sladek, S.R. Murthy Madiraju, Fahd Al-Mulla, Marc Prentki
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101609- (2022)
Objective: Glycerol-3-phosphate (Gro3P) phosphatase (G3PP) hydrolyzes Gro3P to glycerol that exits the cell, thereby operating a “glycerol shunt”, a metabolic pathway that we identified recently in mammalian cells. We have investigated the role o
Externí odkaz:
https://doaj.org/article/ef4e4aa106094673b2a836cb280c8599
Autor:
Pegah Poursharifi, Camille Attané, Yves Mugabo, Anfal Al-Mass, Anindya Ghosh, Clémence Schmitt, Shangang Zhao, Julian Guida, Roxane Lussier, Heidi Erb, Isabelle Chenier, Marie-Line Peyot, Erik Joly, Christophe Noll, André C. Carpentier, S.R. Murthy Madiraju, Marc Prentki
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Enhanced energy expenditure in brown (BAT) and white adipose tissues (WAT) can be therapeutic against metabolic diseases. We examined the thermogenic role of adipose α/β-hydrolase domain 6 (ABHD6), which hydrolyzes monoacylglycerol (MAG), by employ
Externí odkaz:
https://doaj.org/article/e11e5cce8e0b4e328113e9c46cedfd1c
Akademický článek
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Autor:
Alexandre Fisette, Stephanie Tobin, Léa Décarie-Spain, Khalil Bouyakdan, Marie-Line Peyot, S.R. Murthy Madiraju, Marc Prentki, Stephanie Fulton, Thierry Alquier
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1217-1226 (2016)
Summary: α/β-Hydrolase domain 6 (ABHD6) is a monoacylglycerol hydrolase that degrades the endocannabinoid 2-arachidonoylglycerol (2-AG). Although complete or peripheral ABHD6 loss of function is protective against diet-induced obesity and insulin r
Externí odkaz:
https://doaj.org/article/38c0435357f247599bf5d59aad540d0a
Autor:
Shangang Zhao, Yves Mugabo, Gwynne Ballentine, Camille Attane, Jose Iglesias, Pegah Poursharifi, Dongwei Zhang, Thuy Anne Nguyen, Heidi Erb, Raphael Prentki, Marie-Line Peyot, Erik Joly, Stephanie Tobin, Stephanie Fulton, J. Mark Brown, S.R. Murthy Madiraju, Marc Prentki
Publikováno v:
Cell Reports, Vol 14, Iss 12, Pp 2872-2888 (2016)
Suppression of α/β-domain hydrolase-6 (ABHD6), a monoacylglycerol (MAG) hydrolase, promotes glucose-stimulated insulin secretion by pancreatic β cells. We report here that high-fat-diet-fed ABHD6-KO mice show modestly reduced food intake, decrease
Externí odkaz:
https://doaj.org/article/84a1d24e99c3458a8ee984390c17eca2
Autor:
Shangang Zhao, Pegah Poursharifi, Yves Mugabo, Emily J. Levens, Kevin Vivot, Camille Attane, Jose Iglesias, Marie-line Peyot, Erik Joly, S.R. Murthy Madiraju, Marc Prentki
Publikováno v:
Molecular Metabolism, Vol 4, Iss 12, Pp 940-950 (2015)
Objective: α/β-Hydrolase domain-6 (ABHD6) is a newly identified monoacylglycerol (MAG) lipase. We recently reported that it negatively regulates glucose stimulated insulin secretion (GSIS) in the β cells by hydrolyzing lipolysis-derived MAG that a
Externí odkaz:
https://doaj.org/article/e5610cda190f46468b9fa1ed0a75430a
Publikováno v:
Diabetologia. 63:10-20
Significant advances have been made in deciphering the mechanisms underlying fuel-stimulated insulin secretion by pancreatic beta cells. The contribution of the triggering/ATP-sensitive potassium (KATP)-dependent Ca2+ signalling and KATP-independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1515ab585eb3dde45e9f3b440df4c7ce
https://doi.org/10.1007/s00125-019-04976-w
https://doi.org/10.1007/s00125-019-04976-w
Autor:
Marc Prentki, Roxane Lussier, Anfal Al-Mass, Emily Levens, Marie-Line Peyot, Yves Mugabo, Heidi Erb, S.R. Murthy Madiraju, Pegah Poursharifi, Elite Possik, Julian Guida, Erik Joly, Robert Sladek
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d6f27256faf743e0391781cabfad374
https://doi.org/10.1096/fasebj.2021.35.s1.01592
https://doi.org/10.1096/fasebj.2021.35.s1.01592
Autor:
Yat Hei Leung, Rasheed Ahmad, Fahd Al-Mulla, Sardar Sindhu, Marc Prentki, Hossein Arefanian, S.R. Murthy Madiraju
Publikováno v:
Obesity Reviews
Summary Sphingolipids, in particular ceramides, play vital role in pathophysiological processes linked to metabolic syndrome, with implications in the development of insulin resistance, pancreatic ß‐cell dysfunction, type 2 diabetes, atheroscleros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0b215a8befa6f85cbec12cd240b5b2
https://doi.org/10.1111/obr.13248
https://doi.org/10.1111/obr.13248