Poly(ADP-Ribose) Polymerase Inhibitors for Arsenic Trioxide–Resistant Acute Promyelocytic Leukemia: Synergistic In Vitro Antitumor Effects with Hypomethylating Agents or High-Dose Vitamin C

Autor: Grazia Graziani, Maria Domenica Divona, Maria Teresa Voso, Antonio De Gabrieli, Fabio Ciccarone, Manuela Giansanti, Isabella Faraoni, Terry Karimi, Tiziana Ottone, S.P. Prete

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 377:385-397

Arsenic trioxide (ATO) is an anticancer agent used for the treatment ofacute promyelocytic leukemia (APL). However, 5%–10% of patients fail to respond or experience disease relapse. Based on poly(ADP-ribose) polymerase (PARP) 1 involvement in the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70d45cf8fcccb1778f3412948705d2f
https://doi.org/10.1124/jpet.121.000537

Biomolecular Fishing for Calixarene Partners by a Chemoproteomic Approach

Autor: Adriana Ladeira de Araújo, Carmine Gaeta, Beatrice Macchi, S.P. Prete, Luigi Margarucci, Maria Chiara Monti, Stefano Tommasone, Placido Neri, Agostino Casapullo, Carmen Talotta

MS-based chemical-proteomics technology is introduced herein as a third general strategy to study the biomolecular recognition properties of given calixarene derivatives. In particular, we demonstrate that a simply designed calix[4]arene derivative 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ea085bc6020038fc6cf7b472673c2a
http://hdl.handle.net/2108/132883

Influence ofMycobacterium bovisBacillus Calmette Guérin on In Vitro Induction of CD1 Molecules in Human Adherent Mononuclear Cells

Autor: Alessandra Balduzzi, Angelo Aquino, Graziella Orefici, Lanfranco Fattorini, Grazia Graziani, Steven A. Porcelli, Enzo Bonmassar, Anna Giuliani, Elisabetta Iona, S.P. Prete, Masahiko Sugita, Michael B. Brenner

Publikováno v: Infection and immunity
69 (2001): 7461–7470.
info:cnr-pdr/source/autori:Giuliani A., Prete S.P., Graziani G., Aquino A., Balduzzi A., Sugita M., Brenner M.B., Iona E., Fattorini L., Orefici G., Porcelli S.A., Bonmassar E./titolo:Influence of Mycobacterium bovis Bacillus Calmette Guérin on in vitro induction of CD1 molecules in human adherent mononuclear cells./doi:/rivista:Infection and immunity (Print)/anno:2001/pagina_da:7461/pagina_a:7470/intervallo_pagine:7461–7470/volume:69

Nonpeptide antigens (including glycolipids of microbial origin) can be presented to T cells by CD1 molecules expressed on monocyte-derived dendritic cells. These HLA unrestricted responses appear to play a role in host immunity againstMycobacterium t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c016698786f43cdc794d973f9c6114c8
https://doi.org/10.1128/iai.69.12.7461-7470.2001

Exogenous Control of the Expression of Group I CD1 Molecules Competent for Presentation of Microbial Nonpeptide Antigens to Human T Lymphocytes

Autor: Stefania D'Atri, S.P. Prete, Laura Bonmassar, Grazia Graziani, Enzo Bonmassar, Ornella Franzese, Angelo Aquino

Publikováno v: Clinical and Developmental Immunology
Clinical and Developmental Immunology, Vol 2011 (2011)

Group I CD1 (CD1a, CD1b, and CD1c) glycoproteins expressed on immature and mature dendritic cells present nonpeptide antigens (i.e., lipid or glycolipid molecules mainly of microbial origin) to T cells. Cytotoxic CD1-restricted T lymphocytes recogniz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3b130f5d38c305ca86c8d22ae3a076
http://europepmc.org/articles/PMC3095450

Combined effects of protein kinase inhibitors and 5-fluorouracil on CEA expression in human colon cancer cells

Autor: Pierpaolo Correale, Susanne Baier, Liana De Vecchis, Lorena Rossi, Giuliana Tamburrelli, S.P. Prete, Mario Turriziani, Angelo Aquino, Enzo Bonmassar

Publikováno v: Pharmacological research. 52(2)

Previous studies showed that 5-fluorouracil (5-FU) and Staurosporine (ST), a protein kinase inhibitor (PKI), were able to increase the expression of carcinoembryonic antigen (CEA) in human colon cancer cells. In the present study, we examined the in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82515c419fbfa9fc5b64f41d2280952
https://pubmed.ncbi.nlm.nih.gov/15967383