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pro vyhledávání: '"S.L. Levy"'
Akademický článek
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Akademický článek
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Publikováno v:
Macromolecules. 48:9007-9014
We experimentally investigate the stretching and relaxation of individual double-stranded DNA molecules in nanofluidic slits with depths that span the regime between moderate and strong confinement. DNA molecules are stretched by the application of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d40be177977f3683cac2d02a57587ae
https://doi.org/10.1021/acs.macromol.5b01712
https://doi.org/10.1021/acs.macromol.5b01712
Publikováno v:
Soft matter. 13(37)
Manipulating and measuring single-molecule dynamics and reactions in nanofluidics is a rapidly growing field with broad applications in developing new biotechnologies, understanding nanoconfinement effects in vivo, and exploring new phenomena in conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b0dcf86beac22199a713ac8f92d88c
https://pubmed.ncbi.nlm.nih.gov/28868564
https://pubmed.ncbi.nlm.nih.gov/28868564
Autor:
S.L. Levy, Christine P. Tan, James A. Hagarman, Paul D. Soloway, Patrick J. Murphy, Harold G. Craighead, Jaime J. Benítez, Juraj Topolancik, Benjamin Cipriany, Aline Cerf, David R. Latulippe
Publikováno v:
Proceedings of the National Academy of Sciences. 109:8477-8482
Epigenetic modifications, such as DNA and histone methylation, are responsible for regulatory pathways that affect disease. Current epigenetic analyses use bisulfite conversion to identify DNA methylation and chromatin immunoprecipitation to collect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f526c5458fe65e6f353468b69b8084
https://doi.org/10.1073/pnas.1117549109
https://doi.org/10.1073/pnas.1117549109
Autor:
Jing Tang, Harold G. Craighead, S.L. Levy, Jeremy J. Jones, Patrick S. Doyle, Daniel W. Trahan
Publikováno v:
Macromolecules. 43:7368-7377
We experimentally investigated the equilibrium conformation and dynamics of single DNA molecules in slitlike nanochannels. We measured the in-plane radius of gyration (R ) diffusivity (D), and longest relaxation time (τ)ofλ-DNA (48.5 kbp) as functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b475ab3a0ee543c63f9d9b1c8ac9f4
https://doi.org/10.1021/ma101157x
https://doi.org/10.1021/ma101157x
Autor:
Paul D. Soloway, Harold G. Craighead, Ruqian Zhao, Benjamin Cipriany, Christine P. Tan, Patrick J. Murphy, S.L. Levy
Publikováno v:
Analytical Chemistry. 82:2480-2487
Epigenetic states are governed by DNA methylation and a host of modifications to histones bound with DNA. These states are essential for proper developmentally regulated gene expression and are perturbed in many diseases. There is great interest in i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22aec74d55b04043d3ad84d250c7c033
https://doi.org/10.1021/ac9028642
https://doi.org/10.1021/ac9028642
Publikováno v:
Macromolecules. 41:7716-7721
We observed the free diffusion of individual 10 kbp, (1/2)λ (24.2 kbp), and λ (48.5 kbp) double-stranded deoxyribonucleic acid (DNA) molecules in fused-silica nanoslits with depths from 541 to 24 nm using epifluorescence video microscopy. Diffusivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::887114aecdf076e1c4b32c4cf33ce2a5
https://doi.org/10.1021/ma801313w
https://doi.org/10.1021/ma801313w
Autor:
Lingling Wu, S.L. Levy
Publikováno v:
Biomicrofluidics. 8(4)
We studied the mobility of DNA molecules driven by an electric field through a nanofluidic device containing a periodic array of deep and shallow regions termed entropic traps. The mobility of a group of DNA molecules was measured by fluorescent vide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20090205a6480aa1aef6eb7efe8b7319
https://pubmed.ncbi.nlm.nih.gov/25379088
https://pubmed.ncbi.nlm.nih.gov/25379088
Single DNA molecules confined to nanoscale fluidic channels extend along the channel axis in order to minimize their conformational free energy. When such molecules are forced into a nanoscale fluidic channel under the application of an external elec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe2b94fdd16ecdd23c556684f399d08
https://europepmc.org/articles/PMC3755366/
https://europepmc.org/articles/PMC3755366/
