Zobrazeno 1 - 10
of 32
pro vyhledávání: '"S.J. Kaczmarczyk"'
Publikováno v:
Metabolism. 45:622-626
Increased hepatic glucose production, a feature of (non-insulin-dependent diabetes mellitus [NIDDM]), is present at an early age in the New Zealand Obese (NZO) mouse and is associated with impaired suppression of the gluconeogenic enzyme, fructose-1,
Autor:
G. Rosella, Joseph Proietto, S.J. Kaczmarczyk, Jeffrey D Zajac, Louise Baker, Timothy E. Adams, Sofianos Andrikopoulos
Publikováno v:
Molecular Endocrinology. 9:1396-1404
The effects of an overexpressed, non-insulin-responsive gluconeogenic enzyme, phosphoenolpyruvate carboxykinase (GTP) (PEPCK; EC 4.1.1.32), on glucose homeostasis were investigated. Transgenic rats harboring a metallothionein-driven PEPCK gene (lacki
Autor:
Anne W. Thorburn, Joseph Proietto, Elizabeth Gaskin, S.J. Kaczmarczyk, G. Rosella, Jeffrey D Zajac, Sofianos Andrikopoulos
Publikováno v:
Diabetes. 42:1731-1736
The New Zealand obese mouse, a model of NIDDM, is characterized by hyperglycemia, hyperinsulinemia, and hepatic and peripheral insulin resistance. The aim of this study was to investigate the biochemical basis of hepatic insulin resistance in NZO mic
Publikováno v:
Molecular Endocrinology. 7:1456-1462
Despite detailed knowledge of the regulation of individual steps in the gluconeogenic pathway, the relative importance of each step to the overall control of gluconeogenesis by insulin is not known. The aim of this study was to determine the role of
Autor:
John Y F Wong, Gavin Fabinyi, S.J. Kaczmarczyk, Frederick A.O. Mendelsohn, David W. Howells, Geoffrey A. Donnan, Peter J. Chilcho
Publikováno v:
Brain Research. 622:285-288
To test the hypothesis that proliferation of host dopaminergic tissue in response to injury plays an important role in the response to intrastriatal grafting, we transplanted autologous adrenal medullary to striatum in normal C57-black mice and compa
Autor:
George Paxinos, D G Woodhouse, A J Churchyard, R. M. Kalnins, Gavin Fabinyi, Frederick A. O. Mendelsohn, Geoffrey A. Donnan, S.J. Kaczmarczyk, J E Holder, P J Chilco
Publikováno v:
Molecular Neurobiology. 5:421-433
A series of compensatory mechanisms within the dopaminergic system have been shown to maintain clinical function in the presence of dopamine loss. Experimental evidence for increased presynaptic dopamine turnover owing to increased dopamine synthesis
Autor:
V. Grill, G.M.F Pasquini, Rachel A Davey, S.J. Kaczmarczyk, Patricia W. M. Ho, Jeffrey D Zajac, V.P Michelangeli
Publikováno v:
Bone. 31(5)
Parathyroid hormone-related protein (PTHrP) has been implicated as being important in the growth of tumor cells responsive to the peptide. We utilized a rat osteoblastic osteosarcoma cell line, UMR 106-01, which has PTHrP receptors and a PTHrP-respon
Publikováno v:
Molecular and cellular endocrinology. 94(1)
Transcriptional regulation of the human parathyroid hormone-related protein (PTHrP) gene by calcitonin was examined in a lung cancer line (BEN cells). Northern analysis demonstrated that calcitonin caused a rapid 4.5-fold elevation in PTHrP mRNA. Tra
Autor:
S.J. Kaczmarczyk, Geoffrey A. Donnan, Peter J. Chilco, R. M. Kalnins, Dianne G. Woodhouse, Frederick A. O. Mendelsohn, George Paxinos
Publikováno v:
The Journal of comparative neurology. 304(3)
Because of the importance of the catecholamine system in Parkinson's disease and its relevance to a variety of clinical movement disorders, catecholamine uptake sites were mapped in the human brain using [3H] mazindol autoradiography. Displacement st
Publikováno v:
Journal of the Neurological Sciences. 77:185-191
Motor function was assessed by use of a swim test in C57 Black mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Thirty minutes after the last MPTP injection significant motor impairment was observed while striatal dopamine was r