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Role of estrogen receptor (ER) α in insulin-like growth factor (IGF)-I-induced responses in MCF-7 breast cancer cells

Autor: Roger Smith, Robert C. Burghardt, X Li, S.H. Safe, S Zhang

Publikováno v: Journal of Molecular Endocrinology. 35:433-447

Insulin-like growth factor-I (IGF-I) is a mitogenic polypeptide that induces proliferation of MCF-7 breast cancer cells, and cotreatment with the phosphoinositide 3-kinase (PI3-K) inhibitor LY294002 and the antiestrogen ICI 182780 inhibits IGF-I-indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b381c1530c94f56b5c6d4dbe98370364
https://doi.org/10.1677/jme.1.01858

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PCDD, PCDF, and PCB in farm-raised catfish from Southeast United States - concentrations, sources, and CYP1A induction

Autor: M. Hjelt, S.H. Safe, Keith R. Cooper, M. Bonner, Heidelore Fiedler, K. Willett, F. Howell, Sture Bergek, C. Rappe

Publikováno v: Chemosphere. 37:1645-1656

Nine catfish fillets, three catfish nuggets, two feed samples, and one pond sediment were analyzed for PCDD, PCDF, and PCB. Farm-raised catfish from Mississippi, Alabama, and Arkansas contained significant levels of 2,3,7,8-substituted PCDD and PCDF.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcab0be7b5356062a230b81240e1a5c
https://doi.org/10.1016/s0045-6535(98)00231-8

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Comparative32P-postlabeling analysis of exogenous and endogenous DNA adducts in mouse skin exposed to a wood-preserving waste extract, a complex mixture of polycyclic and polychlorinated chemicals

Autor: Kurt Randerath, Guo-Dong Zhou, Kirby C. Donnelly, Erika Randerath, S.H. Safe

Publikováno v: Environmental and Molecular Mutagenesis. 29:372-378

Wood preserving waste (WPW) sites contain numerous toxic compounds, including phenols, polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzodioxins, and dibenzofurans. Previous in vitro and in vivo 32 P-postlabeling studies showed the indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::040ce746493b01274e79804dd52d8bdb
https://doi.org/10.1002/(sici)1098-2280(1997)29:4<372::aid-em5>3.0.co

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Failure of Chloro-S-triazine-Derived Compounds to Induce Estrogen Receptor-Mediated Responsesin Vivoandin Vitro

Autor: Timothy R. Zacharewski, Ichen Chen, K. Berhane, C. Sciarretta, J. Howell, S.H. Safe, K. Connor, H. Liu

Publikováno v: Fundamental and Applied Toxicology. 30:93-101

The potential estrogenic activities of atrazine and simazine were investigated in vivo using the immature female Sprague–Dawley rat uterus and in vitro using the estrogen-responsive MCF-7 human breast cancer cell line and the estrogen-dependent rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b419bd9a69b0309c72b0848457ef201e
https://doi.org/10.1006/faat.1996.0046

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Toxic equivalency factor approach for risk assessment of combustion by‐products

Autor: Lewis V. Rodriguez, S.H. Safe, Lawrence S.B. Goldstein

Publikováno v: Toxicological & Environmental Chemistry. 49:181-191

Hazard and risk assessment of individual toxic chemicals utilizes data obtained from chronic toxicity and carcinogenicity studies in laboratory animals for regulating emission, cleanup or intake levels for individual chemicals. This approach can be u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c195087d906179c7abf7f51f7a1ca9f
https://doi.org/10.1080/02772249509358192

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Bioassay-based risk assessment of complex mixtures

Autor: Kurt Randerath, S.H. Safe, Erika Randerath, Kirby C. Donnelly

Publikováno v: Journal of Hazardous Materials. 41:341-350

In order to compare a standard chemical-based risk assessment with in vitro genotoxicity assays, two complex environmental mixtures from a wood-preserving site were analyzed in the Salmonella/microsome and E. coli prophage induction assays. Using GC/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8d5e4985d97eae913fb921ca447109b
https://doi.org/10.1016/0304-3894(94)00107-r

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Mechanism of Action of α-Naphthoflavone as an Ah Receptor Antagonist in MCF-7 Human Breast Cancer Cells

Autor: V Krishnan, Mark Merchant, S.H. Safe

Publikováno v: Toxicology and Applied Pharmacology. 120:179-185

alpha-Naphthoflavone (alpha NF) and 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) inhibited 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced CYP1A1 gene expression in MCF-7 human breast cancer cells and also decreased the accumulation of the nuclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13eb3f027771ef4aa130e738a167922f
https://doi.org/10.1006/taap.1993.1101

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Akademický článek

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Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as an antiestrogen in MCF-7 human breast cancer cells

Autor: T.R. Narisimhan, V. Krishnan, S.H. Safe

Publikováno v: Chemosphere. 25:947-950

The effects of 1 nM 17β-estradiol, 1 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and their combination on the formation of intracellular cytosolic 52- and 34-kDa proteins was determined using a commercially available cathepsin D radioimmunoassay p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0515f9a9c5d83bab19b3b087db0e74da
https://doi.org/10.1016/0045-6535(92)90089-a

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