Zobrazeno 1 - 10
of 23
pro vyhledávání: '"S.G. Panzer-Knodle"'
Autor:
S.G. Panzer-Knodle, Kam F. Fok, Larry P. Feigen, Steven Paul Adams, Nancy S. Nicholson, Foe S. Tjoeng
Publikováno v:
International Journal of Peptide and Protein Research. 38:124-130
Tetrapeptides containing the sequence Arg-Gly-Asp (RGD) antagonize fibrinogen binding to its platelet receptor (gp IIb/IIIa, integrin alpha IIb beta 3) and inhibit platelet aggregation in vitro. The peptides RGDS and RGDY(Me)-NH2 were rapidly degrade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d67a4cc0688e8be95fbe04ff42431fa
https://doi.org/10.1111/j.1399-3011.1991.tb01419.x
https://doi.org/10.1111/j.1399-3011.1991.tb01419.x
Autor:
Jeffery Alan Zablocki, Neal F. Haas, Anita K. Salyers, S.G. Panzer-Knodle, Beatrice B. Taite, Larry P. Feigen, Marc Herin, Kay Broschat, Lucy W. King, Phillipe Jacqmin, Bradley T. Keller, V. Wayne Engleman, Nancy S. Nicholson, James A. Szalony
Publikováno v:
Circulation. 91:403-410
Background Intravenous therapy has been shown to be beneficial in the prevention of acute platelet-associated thrombotic events. However, orally active agents would be advantageous for chronic therapy. Fibrinogen receptor antagonists block the fibrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336714372463ad6d39ffad92b62638ee
https://doi.org/10.1161/01.cir.91.2.403
https://doi.org/10.1161/01.cir.91.2.403
Autor:
Dudley E. McMackins, Mihaly V. Toth, Henry E. Dayringer, J. G. Rico, P. R. Bovy, Nancy S. Nicholson, Anita K. Salyers, Beatrice B. Taite, Jeffery Alan Zablocki, Larry P. Feigen, Thomas E. Rogers, Shashidhar N. Rao, Mark E. Zupec, Robert Bruce Garland, Steven Paul Adams, M. Herin, R. J. Lindmark, Foe S. Tjoeng, S.G. Panzer-Knodle, Masateru Miyano
Publikováno v:
Bioorganic & Medicinal Chemistry. 2:881-895
The evolutionary process from the Arg-Gly-Asp-Phe (RGDF) tetrapeptide to potent orally active anti-platelet agents is presented. The RGD sequence is an important component in the recognition of fibrinogen by its platelet receptor GP IIb-IIIa (integri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ff7ca1e73492c493b88cb344c8d089
https://doi.org/10.1016/s0968-0896(00)82038-6
https://doi.org/10.1016/s0968-0896(00)82038-6
Autor:
Nancy S. Nicholson, Jeffery Alan Zablocki, R. J. Lindmark, D Pireh, Robert Bruce Garland, Beatrice B. Taite, Masateru Miyano, Shashidhar N. Rao, L Schretzman, S.G. Panzer-Knodle
Publikováno v:
Journal of Medicinal Chemistry. 36:1811-1819
Peptide mimetics of the RGDF sequence in which Arg-Gly has been replaced with 5-(4-amidinophenyl)pentanoyl mimetic has led to a 1000-fold increase in inhibitory potency over the natural RGDF ligand. The guanidine residue of the arginine may be involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d418001710ed44efdbaa4f9aa830654d
https://doi.org/10.1021/jm00065a003
https://doi.org/10.1021/jm00065a003
Autor:
Larry P. Feigen, S.G. Panzer-Knodle, P. Jacqmin, V. W. Engleman, J. D. Page, Nancy S. Nicholson, Jeffery Alan Zablocki
Publikováno v:
Platelets. 6(5)
In order to compare binding of small peptide mimetics on activated vs resting platelets and with fibrinogen (fgn) on activated platelets, the binding of [(3)H]-SC-52012, a low molecular weight (483) mimetic of the RGDF sequence present in fgn, was ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d2811bc34d9832d3335c7dc3f49dfc
https://pubmed.ncbi.nlm.nih.gov/21043715
https://pubmed.ncbi.nlm.nih.gov/21043715
Autor:
Neal F. Haas, David M. Lansky, Beatrice B. Taite, Nancy S. Nicholson, Anita K. Salyers, Jimmy D. Page, James A. Szalony, Larry P. Feigen, S.G. Panzer-Knodle
Publikováno v:
American heart journal. 135(5 Pt 2)
Optical aggregometry, traditionally used to assess platelet function, is highly dependent on sample preparation and technical procedure; as a result, data from various laboratories can be quite variable. In a study designed to assess the sources of v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18d211dcd17134dbeeb8a43003dfd35
https://pubmed.ncbi.nlm.nih.gov/9588396
https://pubmed.ncbi.nlm.nih.gov/9588396
Autor:
S.G. Panzer-Knodle, Lucy W. King, Nancy S. Nicholson, V. Wayne Engleman, F.Siong Tjoeng, Brad T. Keller, Todd D. Giorgio, Beatrice B. Taite, Larry P. Feigen
Publikováno v:
Thrombosis research. 74(5)
Fibrinogen binding is required for platelet aggregation and subsequent thrombus formation. SC-49992 (SC), an RGDF mimetic, is a potent and specific inhibitor of the binding of fibrinogen to its receptor on activated platelets, glycoprotein IIb/IIIa (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a380664a102cffa910569c2b62b7614
https://pubmed.ncbi.nlm.nih.gov/8085253
https://pubmed.ncbi.nlm.nih.gov/8085253
Autor:
Devan V. Mehrotra, Larry P. Feigen, Nancy S. Nicholson, Beatrice B. Taite, S.G. Panzer-Knodle
Publikováno v:
Journal of pharmacological and toxicological methods. 30(1)
Differences exist between platelets of different species in their reaction to pharmaceutical agents, such as inhibitors of platelet aggregation. Understanding these differences is critical in the interpretation of data from experimental animal models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44bb91ecfcd6c196c688bae9ac887bc3
https://pubmed.ncbi.nlm.nih.gov/8241546
https://pubmed.ncbi.nlm.nih.gov/8241546
Autor:
Larry P. Feigen, Nancy S. Nicholson, S.G. Panzer-Knodle, Shashidhar N. Rao, Jeffery Alan Zablocki, Masateru Miyano
Publikováno v:
Journal of medicinal chemistry. 35(26)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67b5e0f4ed6b9111edb46cdf7b4225a
https://pubmed.ncbi.nlm.nih.gov/1479591
https://pubmed.ncbi.nlm.nih.gov/1479591
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