Zobrazeno 1 - 10
of 37
pro vyhledávání: '"S.E. Barrie"'
Autor:
S.E. Barrie, Martin G. Rowlands, Ferdinand Chan, Michael Jarman, Ben P. Haynes, Gerard A. Potter, John Houghton
Publikováno v:
Journal of Medicinal Chemistry. 39:3319-3323
Various 3- and 4-pyridylalkyl 1-adamantanecarboxylates have been synthesized and tested for inhibitory activity toward the 17 alpha-hydroxylase and C17,20-lyase activities of human testicular cytochrome P450(17 alpha). The 4-pyridylalkyl esters were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3c0a71aff4f8d6e086f763dc69fae3
https://doi.org/10.1021/jm950749y
https://doi.org/10.1021/jm950749y
Autor:
S.E. Barrie, Gerard A. Potter, Martin G. Rowlands, John Houghton, Raymond McCague, Ferdinand Chan, Michael Jarman
Publikováno v:
Journal of Medicinal Chemistry. 38:4191-4197
Esters of 3- and 4-pyridylacetic acid have been prepared and tested for inhibitory activity toward the human testicular 17 alpha-hydroxylase/C17,20-lyase and human placental aromatase enzymes. The structural features required for optimal inhibition o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15933c0a3e9fd275d93665861e28aab
https://doi.org/10.1021/jm00021a008
https://doi.org/10.1021/jm00021a008
Publikováno v:
Journal of Medicinal Chemistry. 38:2463-2471
Steroidal compounds having a 17-(3-pyridyl) substituent together with a 16,17-double bond have been synthesized, using a palladium-catalyzed cross-coupling reaction of a 17-enol triflate with diethyl(3-pyridyl)borane, which are potent inhibitors of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7332fae691101ed326018adedf0fd7e
https://doi.org/10.1021/jm00013a022
https://doi.org/10.1021/jm00013a022
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 50:267-273
Medical or surgical castration for the treatment of prostatic cancers prevents androgen production by the testes, but not by the adrenals. Inhibition of the key enzyme for androgen biosynthesis, cytochrome P450(17) alpha, could prevent androgen produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a64c852d999cc36f6ca011e44fccf383
https://doi.org/10.1016/0960-0760(94)90131-7
https://doi.org/10.1016/0960-0760(94)90131-7
Autor:
Martin G. Rowlands, S.E. Barrie, Raymond McCague, J. J. Deadman, John Houghton, Michael Jarman
Publikováno v:
Journal of Medicinal Chemistry. 33:2452-2455
In a search for inhibitors of 17 alpha-hydroxylase-C17,20-lyase and testosterone-5 alpha-reductase, target enzymes in the development of drugs to treat hormone-dependent prostatic cancer, we have identified certain compounds chemically derived by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b36403ce6a4efb3da0916c8631663e1
https://doi.org/10.1021/jm00171a019
https://doi.org/10.1021/jm00171a019
Publikováno v:
Journal of medicinal chemistry. 41(27)
Abiraterone (17-(3-pyridyl)androsta-5,16-dien-3beta-ol, 1) is a potent inhibitor (IC50 4 nM for hydroxylase) of human cytochrome P45017alpha. To assist in studies of the role of the 16,17-double bond in its mechanism of action, the novel 17alpha-(4-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf321024c1434d4647fad2fedbb2dee
https://pubmed.ncbi.nlm.nih.gov/9876107
https://pubmed.ncbi.nlm.nih.gov/9876107
Autor:
Ben P. Haynes, Mitchell Dowsett, P.M. Goddard, Ferdinand Chan, Michael Jarman, Gerard A. Potter, S.E. Barrie
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 60(5-6)
Two potent non-steroidal inhibitors (CB7645 and CB7661) of human cytochrome P450 17α were tested for in vivo activity in WHT mice. There were no signs of toxicity, but there was no effect on the androgen-dependent organs. The pharmacokinetics and bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b78027005bdb7c733be7e49b71bb20
https://pubmed.ncbi.nlm.nih.gov/9219927
https://pubmed.ncbi.nlm.nih.gov/9219927
Publikováno v:
Journal of medicinal chemistry. 33(11)
A variety of esters of 4-pyridylacetic acid have been prepared by base mediated exchange from the methyl ester. Several of the esters of alcohols that contained a cyclohexyl ring were potent inhibitors of human placental aromatase and of the rat test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf357f0c8529f59c72ca350c53379b43
https://pubmed.ncbi.nlm.nih.gov/2231604
https://pubmed.ncbi.nlm.nih.gov/2231604
Publikováno v:
Journal of Steroid Biochemistry. 33:1191-1195
A simple assay for the measurement of the activities of both 17 alpha-hydroxylase and C17-C20 lyase is described. No extraction procedures are required. The separation of substrate and products is achieved using HPLC which allows the collection of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375fb0c22038ac077a3051bff5a5efd3
https://doi.org/10.1016/0022-4731(89)90429-9
https://doi.org/10.1016/0022-4731(89)90429-9
Autor:
S.E. Barrie, Alan J. Williams
Publikováno v:
Biochemical and biophysical research communications. 84(1)
The relationship between the initial rates of respiration dependent calcium transport by isolated rabbit cardiac mitochondria and the free calcium concentration of the reaction media has been examined at 10°C and 25°C. Initial rates of calcium tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a599373bbac6a20c357c4a9c8259eeda
https://pubmed.ncbi.nlm.nih.gov/728140
https://pubmed.ncbi.nlm.nih.gov/728140