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Functional characterization of iPSC-derived arterial- and venous-like endothelial cells

Autor: L. Silva Ferreira, Patrícia R. Pitrez, Catarina Praça, P. José Gouveia, Xabier L. Aranguren, S.C. Rosa, Leonardo Ricotti

Publikováno v: Scientific Reports
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

The current work reports the functional characterization of human induced pluripotent stem cells (iPSCs)- arterial and venous-like endothelial cells (ECs), derived in chemically defined conditions, either in monoculture or seeded in a scaffold with m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e121bf6833489760a3626dc1a91f7874
https://hdl.handle.net/10316/86311

Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells

Autor: Emmanuel Sevin, Marie-Pierre Dehouck, Catarina Praça, Lino Ferreira, Roméo Cecchelli, S.C. Rosa

Publikováno v: Stem Cell Reports
Stem Cell Reports, Elsevier, 2019, 13 (4), pp.599-611. ⟨10.1016/j.stemcr.2019.08.002⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Summary The derivation of human brain capillary endothelial cells is of utmost importance for drug discovery programs focusing on diseases of the central nervous system. Here, we describe a two-step differentiation protocol to derive brain capillary-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a2bf9ce52a18badecdf5efa95b6ec6c
https://pubmed.ncbi.nlm.nih.gov/31495714

High-throughput identification of small molecules that affect human embryonic vascular development

Autor: Margreet R. de Vries, Carlos Filipe Pereira, Dimitri Papatsenko, Inês Honório, Daniel B.F. Saris, Helena Vazão, Nadia Mercader, Lino Ferreira, Hugo Fernandes, Tânia Barata, Ricardo Costa, Ali Khademhosseini, Paul H.A. Quax, Patrícia R. Pitrez, S.C. Rosa, Rui Benedito

Publikováno v: Proceedings of the National Academy of Sciences, 114(15), E3022-E3031
Proceedings of the National Academy of Sciences of the United States of America, 114(15), E3022-E3031. National Academy of Sciences

Birth defects, which are in part caused by exposure to environmental chemicals and pharmaceutical drugs, affect 1 in every 33 babies born in the United States each year. The current standard to screen drugs that affect embryonic development is based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310abfaa13025b3dfe6636a7b343a92a
https://hdl.handle.net/1887/95231